Day July 2, 2024

Comparing sessions 1 and 2. Blood oxygenation level-dependent (BOLD) response slopes in the narrow (NR) and wide (WR) reward ranges separately, in the left and right striatum. Credit: Brain (2024). DOI: 10.1093/brain/awae112 Schizophrenia, which affects up to 1% of the…

Gastroesophageal reflux disease (GERD) is associated with an increased incidence of atrial fibrillation, according to a study published online June 2 in Frontiers in Cardiovascular Medicine. Lei Wang and Yi Wei Lu, from the Aerospace Center Hospital in Beijing, and…

U.S. health officials announced Tuesday that the federal government will pay Moderna $176 million to speed development of a pandemic flu vaccine based on mRNA technology. Such a vaccine could be used to treat bird flu in people, as concern…

Transgender, nonbinary, and gender-diverse people face barriers to accessing surgery and to the health system in general, describe authors in two new research papers published in Canadian Medical Association Journal (CMAJ). In many areas of life, people who identify as…

Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a “one-size-fits-all” remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings…

Whole genome sequencing has improved clinical care of some children with cancer in England by informing individual patient care. New research from the Wellcome Sanger Institute, Cambridge University Hospitals NHS Trust, Great Ormond Street Hospital, and the University of Cambridge,…

Differential PVDF cantilever diagram (not to scale). We construct the cantilever from two layers of PVDF sandwiching a flex PCB base. We sputter-coat the charge sense electrodes onto the flex PCB and capacitively couple the electrodes to the PVDF through…

Associations of Resting rCBF with Depression Symptom Severity. These analyses that assessed the association of depression symptom severity on the Beck Depression Inventory (BDI) with resting rCBF were performed in the depressed patients only while covarying for age and sex.…

Nanovials containing individual cells (green) and secreted extracellular vesicles (magenta) within their cavities. Credit: Doyeon Koo/UCLA Selecting specific cells to be used in an investigational therapy has led to improved recovery of heart function in a new study employing a…

New endoscopic neurosurgery approach does not require a large craniotomy, so the result is a smaller scar. Credit: Osaka Metropolitan University Tumors arising in the base of the skull are among the most difficult to remove in neurosurgery. The current…

Two people have fallen ill with dengue fever in the Florida Keys after being bit by infected mosquitoes, prompting health officials to issue an alert for the island chain. The alert comes just days after the U.S. Centers for Disease…

Income and area-level disadvantage are the largest contributors to racial differences in financial hardship among older U.S. adults with cancer, according to a study published online June 18 in Cancer. Elizabeth S. Davis, M.S.P.H., from Boston University, and colleagues conducted…

Schematic of the mechanism of action of ETV5 on TFH cell differentiation. Credit: POSTECH A research team including Professor Yoontae Lee and Jiho Park, a Ph.D. candidate, from the Department of Life Sciences at Pohang University of Science and Technology…

There is an association for housing insecurity starting in infancy and poorer adolescent outcomes, according to a study published online July 1 in Pediatrics. Kristyn A. Pierce, M.P.H., from the NYU Grossman School of Medicine in New York City, and…

The efficiency of PspCas13b silencing is highly variable between crRNAs. Credit: Nature Structural & Molecular Biology (2024). DOI: 10.1038/s41594-024-01336-0 Peter Mac researchers have taken the first step towards designing rapid personalized cancer treatments by ‘cutting out’ disease-causing RNA. The findings,…

It’s not making major news headlines like in the ’80s, but HIV remains a significant health concern. About 38 million people are living with HIV, the virus that causes AIDS, according to the World Health Organization. It’s important to get…

Shhhooo. Wee-uuu. Chick, chick, chick. That’s the sound of three different cicada species. For some people, those sounds are the song of the summer. Others wish the insects would turn it down. The cacophony can be especially irritating for people…

HIV particles (tiny yellow spheres) are attacking a CD4+ T cell shown in blue. The virus preferentially targets T cells, which play a critical role in the body’s immune response against invaders like bacteria and viruses. Credit: Seth Pincus, Elizabeth…

Good news for all the treadmill runners who suffer from stubborn and painful shin splints: A little outdoor gait training may help, new research suggests. A randomized controlled trial found that four weeks of gait training outdoors, in addition to…

Predictor selection, SHAP visualization and performance of machine-learning classification model based on behavior-related phenotypes. a, Sequential forward selection of behavior-related variables. b, SHAP visualization of selected predictors. c, AUC plots for the behavior-related phenotype-based SA classification model. Credit: Nature Human…

A study published in Nature Communications presents the promising results of RecombinHunt, a new data-driven method developed by the Department of Electronics, Information and Bioengineering of the Politecnico di Milano and the University of Milan, which can identify, with high…

Timing (by year) of FDA accelerated approval status of oncology therapeutic indications, results of postapproval confirmatory trial availability as publications, conversion to traditional approval or market withdrawal, and NCCN guideline updates. There were no duplicate indications; several drug treatments were…

Credit: Amina Filkins from Pexels In the fight to reduce longstanding maternal health disparities, group prenatal care programs could be an effective tool, say researchers from Yale School of Medicine (YSM) and Yale School of Public Health. Based on their…

A patient with an unsual MRI and neurologic deficits eluded typical diagnostic tests. Credit: John Pluvinage A large team of doctors and medical researchers with diverse backgrounds, affiliated with several institutions across the U.S., and led by a group at the…

When it comes to managing blood sugar levels, most people think about counting carbs. But new research from the University of British Columbia shows that, for some, it may be just as important to consider the proteins and fats in…

Mutations in the presenilin gene, PSEN1, causes early onset of Alzheimer’s disease in humans and in fruit flies modified to have this gene. A new study led by researchers at Penn State revels that disrupting heparan sulfate–modified proteins in fruit…

Scientists have identified a gene which, when missing or impaired, can cause obesity, behavioral problems and, in mothers, postnatal depression. The discovery, reported in Cell, may have wider implications for the treatment of postnatal depression, with a study in mice…

Close-up of insulinoma cells expressing insulin (red). Credit: Pompeu Fabra University (UPF) A study led by Pompeu Fabra University describes the mechanism whereby insulinomas, a rare type of neuroendocrine tumor that affects pancreatic beta cells, form. According to the study,…

Average facial temperatures of three aging-status groups among women 50–60 years old. Credit: Zhengqing Yu and Jing-Dong J Han A colder nose and warmer cheeks may be a telltale sign of rising blood pressure. Researchers discovered that temperatures in different…

Acute myelocytic leukemia (AML). Researchers show for the first time that engineered human plasma B cells can be used to treat a disease—specifically leukemia—in a humanized animal model. The results mark a key step in the realization of ePCs as…

Gongchen Yu, Ph.D., Leor Katz, Ph.D., and Richard Krauzlis, Ph.D. Credit: Dustin Hays, National Eye Institute Scientists at the National Institutes of Health (NIH) have uncovered a brain circuit in primates that rapidly detects faces. The findings help not only…

Experiment on imagining movements and tactile sensations in the right hand. Credit: Aigul Nasibullina The ability to imagine is one of the key human cognitive functions. In a paper published in the Scientific Reports journal, researchers from Skoltech and Moscow…

Sound stimulation of 75?dB at a frequency of 100?Hz leads to improvement in cervical vestibular-evoked myogenic potential (cVEMP) amplitude in patients with definitive Meniere disease, according to a study published online June 24 in Acta Oto-Laryngologica. Michihiko Sone, M.D., Ph.D.,…

T cell development in the thymus. Credit: Neurology (2024). DOI: 10.1212 The first-ever randomized study of the removal of the thymus gland in treating myasthenia gravis was conducted in 2016. Led by Gil I. Wolfe, MD, SUNY Distinguished Professor and…

Credit: Nathan b Caldeira from Pexels American Indian/Alaska Native (AI/AN) women with breast cancer have consistently lower rates of breast reconstruction after mastectomy compared to non-Hispanic White women, reports a paper in the July issue of Plastic and Reconstructive Surgery.…

Minister for the National Disability Insurance Scheme (NDIS), Bill Shorten, has proposed a number of policy changes to the scheme. It is hoped these will ensure its sustainability for future generations. The proposals and legislative amendments follow a nationwide discussion…

The nigrosome has an intricate and dense network of highways and streets, representing its rich vascularization. This dense network makes the nigrosome a major intersection, a key entry point for traffic, including not only necessary supplies but also potentially harmful…

Graphical abstract. Credit: Molecular Therapy – Methods & Clinical Development (2024). DOI: 10.1016 A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more…

Credit: MART PRODUCTION from Pexels A University of Alberta study shows that PET/CT imaging using a new tracing agent is more accurate at determining the extent of prostate cancer than the current standard MRI for intermediate and high-risk cases. In…

Ankrd11 is expressed in cardiac neural crest cells and ablated in the Ankrd11ncko mouse model. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-48955-1 A new study sheds light on a medical question scientists have long wondered: why do 40% of children with…