Day July 15, 2024

By culturing healthy neuronal progenitor cells (NPCs) within this amyloid-mimicking environment and comparing results to those in a natural-mimicking matrix, the researchers observed elevated levels of neuroinflammation and apoptosis markers. This suggests a significant impact of amyloid-like structures on NPC…

Analysis of the developmental cell atlas. a, Workflow to obtain single-cell RNA (scRNA) expression and CUT&Tag data for three histone modifications (H3K27me3, H3K4me3 and H3K27ac). b, Using MCMF bipartite matching and Cellrank2, we derived multi-omic metacells and constructed a force-directed…

Overview of the RATE-AF randomized trial wearable study. mcg = micrograms; mg = milligrams; RATE-AF = RAte control Therapy Evaluation in permanent Atrial Fibrillation. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03094-4 A study published in Nature Medicine examined if a commercially-available…

by David Hilzenrath, Holly K. Hacker, KFF Health News In 2013, the FDA approved an implantable device to treat leaky heart valves. Among its inventors was Mehmet Oz, the former television personality and former U.S. Senate candidate widely known as…

by Robert W. Frenck Jr., MD, FAAP, American Academy of Pediatrics Credit: Helena Lopes from Pexels When planning a family cookout or packing a picnic to enjoy at the park, pool or beach, keep food safety in mind. Children under…

High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia Dealing with chronic conditions like Crohn’s disease and ulcerative colitis can be challenging and sometimes embarrassing. Inflammatory bowel disease (IBD) can cause diarrhea, stomach pain, weight loss…

HNF4A is methylated and suppressed in pancreatic cancer. Credit: Gastro Hep Advances (2024). DOI: 10.1016 Scientists at Nottingham Trent University, the University of Nottingham, Stanford University and the University of California and Cedars-Sinai Medical Center, Los Angeles, have found that…

It’s been long established that certain men become aggressive when they see their manhood as being threatened. When does this behavior emerge during development—and why? A new study by a team of psychology researchers shows that adolescent boys may also…

Despite treatment-related fertility challenges, female patients can become pregnant and give birth to healthy children after undergoing allogeneic hematopoietic cell transplantation (alloHCT), according to a study published in Blood. During alloHCT, stem cells from a healthy donor are transplanted to…

Discussion about gender identity has become a mainstream topic, with questions surrounding how the brain is wired and how behavior is influenced by someone’s sex or gender. Research from The Feinstein Institutes for Medical Research published in Science Advances shows…

An illustration of different patients’ possible needs and their possible benefit from AI intervention or a human connection in therapy. AI: artificial intelligence. Credit: JMIR Mental Health (2024). DOI: 10.2196/56529 A new study by researchers from the Psychology Department at…

Credit: Advanced Science (2024). DOI: 10.1002 Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson’s disease, shows a recent study. Rather, the formation of protein into liquid droplets may help to dissolve…

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows. In a study, women with chronic pelvic pain who had a naturally occurring…

Early exposure to antibiotics can trigger long term susceptibility to asthma, according to new research from Monash University. Importantly, the research team isolated a molecule produced by gut bacteria that in the future could potentially be trialed as a simple…

Credit: Google DeepMind from Pexels There are many drugs that anesthesiologists can use to induce unconsciousness in patients. Exactly how these drugs cause the brain to lose consciousness has been a longstanding question, but MIT neuroscientists have now answered that…

Electrodes at multiple brain regions reveal brain activity in real time. Colored dots show the locations of all of the electrodes across all patients, color-coded by brain region. Red dots in the lower images show the locations of the electrodes…

Lawmakers in the West African nation of The Gambia have rejected a highly controversial push to try overturn a ban on female genital mutilation. Gambia in 2015 banned the ritual forced on millions of girls in Africa, the Middle East…

Difference in reward response between Depression Cohort and Epilepsy Cohort. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49600-7 As parents, teachers and pet owners can attest, rewards play a huge role in shaping behaviors in humans and animals. Rewards—whether as edible treats,…

About one-third of adults have high blood pressure. Two-thirds of these have uncontrolled high blood pressure. A key driver of poor blood pressure control is people not taking their tablets as prescribed. Tablets have been used to treat high blood…

Alcohol has long held a hallowed place in the consciousness of Canadian society. A more socially acceptable drug than some others, it’s associated with relaxation, socializing and celebration. As a result, alcohol has received an almost free pass when it…

Immigrants make up nearly 16% of Philadelphia’s population of 1.6 million, according to a 2024 report from Pew Charitable Trusts. Pew reports this marks the largest percentage since the 1940s, and above the national percentage of 13.9%. I am a…

Imagine waiting weeks or months for your wheelchair’s battery or custom cushions to be replaced. This is the situation throughout Canada that thousands of people with disabilities face not only in relation to wheelchairs, but also other assistive devices, including…

The summer of sport is well underway. Already we have seen penalty shootout drama at the Euros, defending champion Marketa Vondrousova exiting Wimbledon at the first hurdle and preparations getting underway for the Paris Olympic Games. Regardless of the sport,…