Day September 3, 2024

Researchers from QIMR Berghofer have found that declining melanoma rates among young Australians have been influenced by the country’s increasingly diverse population and more varied skin tones. According to the new research, almost 30% of young Australians now have a…

Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischemic stroke or systemic embolism (blood clot) in older adults aged 75–76 years over 5 years follow-up, according to late breaking research presented in a…

A catheter ablation procedure widely used to treat the most common heart rhythm disorder significantly reduces the burden of atrial fibrillation (AF) and results in clinically important improvements in symptoms and quality of life compared with a sham (placebo) procedure,…

A new, rapid blood test that spots whether people are having a heart attack could improve the treatment of people presenting with chest pain at emergency departments, according to late-breaking research presented in a Hot Line Session Sept. 2 at…

Severe, lasting hot flushes during menopause are associated with atherosclerosis in the coronary artery, new research from Karolinska Institutet and Linköping University and published in the Journal of the American Heart Association reveals. Forty percent of the women who participated…

The benefits of complete revascularization over culprit-only coronary artery revascularization were confirmed in older patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease over the first 4 years, according to late-breaking research presented in a Hot Line session today…

Undergoing percutaneous coronary intervention (PCI) for narrowed arteries with a novel bioadaptor is at least as effective as a contemporary drug-eluting stent (DES) with regard to target lesion and target vessel failure outcomes at one year in a large, broad…

One in three dying people in England and Wales was severely or overwhelmingly affected by pain in the last week of life, with bereaved people reporting how difficult it was to get joined-up support from health and care professionals at…

Mitral transcatheter edge-to-edge repair (M-TEER) reduced cardiovascular death and heart failure (HF)-related hospitalizations with improved health status in patients with HF and moderate to severe functional mitral regurgitation (FMR), according to late-breaking research presented in a Hot Line session today…

Illustration of polymorphous sperm-liked microswimmers (PSMs) production by the VTAM. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49043-0 A research team from the School of Engineering of the Hong Kong University of Science and Technology (HKUST) has developed an innovative magnetic actuation…

A recent study sheds light on the potential long-term neuropsychiatric risks associated with prenatal cannabis exposure. As the global trend toward cannabis legalization continues, the prevalence of cannabis use among pregnant women is on the rise, raising concerns about its…

In patients with newly diagnosed type 2 diabetes, baseline interleukin-6 (IL-6) levels may enhance prediction of new-onset obesity-related cancers, according to a study scheduled to be presented at the annual meeting of the European Association for the Study of Diabetes,…

An mpox outbreak in Africa, driven partly by a new variant that emerged in the Democratic Republic of Congo, has been declared an international emergency and sparked calls for vaccine donations. Here is what you need to know. What is…

Graphical abstract. Credit: Gastro Hep Advances (2024). DOI: 10.1016 Fatigue is a common and often debilitating companion for people with inflammatory bowel conditions. Now, a new Danish study provides insight into why vitamin B1—also known as thiamine—helps some patients regain…

Allyson Choi examining cell cultures in the lab. Credit: Duke-NUS Medical School Like many good detectives, Duke-NUS Integrated Biology and Medicine Ph.D. Program candidate Allyson Choi was undaunted when she was handed a decades-old cold case: a 1970s outbreak of…

Fecal immunochemical tests (FITs) have variable sensitivity and specificity for detecting advanced colorectal neoplasia (ACN), according to a study published online Sept. 3 in the Annals of Internal Medicine. Barcey T. Levy, M.D., Ph.D., from the University of Iowa Carver…

For patients with rheumatoid arthritis, high-intensity interval training (HIIT) and strength exercise are beneficial for cardiovascular health, physical fitness, and overall health, according to a study published online Aug. 23 in the British Journal of Sports Medicine. Annelie Bilberg, Ph.D.,…

Four weeks of low-frequency repeated transcranial magnetic stimulation (rTMS) positively impacts poststroke urinary incontinence, according to a study published online Aug. 8 in Scientific Reports. Jialu Chen, from the Second Affiliated Hospital of Chongqing Medical University in China, and colleagues…

The saccule-to-utricle ratio inversion may serve as an effective imaging marker for diagnosis of early-stage Meniere disease, according to a study published online July 27 in The Laryngoscope. Wenting Deng, M.D., from Sun Yat-Sen Memorial Hospital at Sun Yat-Sen University…

In a sea of cancer cells (blue), macrophages (green) are close neighbors to metastatic-initiating cancer cells (magenta). Credit: Won Jin Ho, Johns Hopkins Kimmel Cancer Center In a study using human breast cancer cells, scientists say they have potentially identified…

FLNB and ACTC1 analysis. (A) mRNA FLNB expression (RT-qPCR) of fibroblasts in quiescence or after 24h of TGF-?-1 stimulation (Mean±SEM, n= 6 for young and old cells); (B) mRNA expression quantified by RT-qPCR after transfection with specific siRNA for FLNB…

The COVID-19 pandemic has been especially hard on individuals with disabilities. New research from the University of Kansas shows that this population is also experiencing long COVID at significantly higher rates than the general population, which exacerbates existing barriers to…

Credit: Zhuangzhuang Yuan et al New research from a team in China has uncovered a novel variant in the MYO1D gene that is linked to laterality defects, congenital heart diseases, and sperm defects in humans. Laterality defects involve the abnormal…

A patient receives a ketamine infusion for depression at the University of Michigan Health clinic, which requires pregnancy testing before treatment begins and weekly testing during treatment, as well as specifically recommending the use of highly reliable forms of contraception…

The figure shows the biodistribution of radioactivity after injecting tumor-bearing mice with [211At]At-NpG-D-PSMA. The results highlight that [211At]At-NpG-D-PSMA accumulates preferentially in tumors while exhibiting low accumulation in the liver and other organs, and therefore holds potential for clinical applications. Credit:…

Researchers at Kessler Foundation have published a new clinical protocol examining the combination of aerobic exercise and cognitive rehabilitation to improve learning and memory in individuals with multiple sclerosis (MS) who have mobility disability. The article, “Rationale and methodology for…

A labeled echo report image, as studied by AI created by the University of Dundee and Red Star AI. Credit: University of Dundee A team from the University’s School of Medicine, working with Red Star AI, were able to identify…

Gut microbiome taxonomic profiles of healthy and non-healthy individuals inform a Lasso-penalized logistic regression classification model. a Principal component analysis (PCA) of gut microbiome profiles. Significant differences in distributions between healthy (disease-free) (blue, n?=?5547) and non-healthy (diseased) (red, n?=?2522) groups…

Credit: AI-generated image Artificial intelligence (AI), in various forms, has burst onto the scene in both society and medicine. Its role in medicine is still evolving, but undoubtedly, it will assist in the evaluation of images (radiographs, pathological reports, videos…

Alternative polyadenylation (APA). Credit: Genomic Psychiatry (2024). DOI: 10.61373 In a comprehensive review of recent genetic studies, researchers have identified a hidden layer of complexity in how our genes function, shedding new light on the biological underpinnings of major psychiatric…

For many doctors and researchers, immunotherapy that uses someone’s own immune system to target and attack cancer cells is the next and best frontier of cancer treatment. Chimeric antigen receptor T-cell therapy, or CAR-T cell therapy, is one type of…

C57BL/6 CD4+/CD8+ T cell mouse depletion model. (a) Study schematic. Blood, turbinates, and lungs were harvested and processed for flow cytometry; n numbers as specified. (b) Body weight curves of mice, normalized to the initial weight before the first depletion…

In this schematic, the first view of E-PHATE takes as inputs a vector of brain activation for each participant and computes a PHATE-based affinity matrix. The second view takes a vector of environment scores for each of those participants and…

Antitumor activity of AZD5305 and olaparib in PDXs. Credit: Genome Medicine (2024). DOI: 10.1186/s13073-024-01370-z Led by investigators of the Vall d’Hebron Institute of Oncology’s (VHIO) Experimental Therapeutics Group, in collaboration with VHIO’s Hereditary Cancer Genetics Group and the Medical Oncology…

Eating any amount of fish during pregnancy was associated with about a 20% lower likelihood of autism spectrum disorder (ASD) diagnosis, particularly in females, and a slight reduction in autism-related traits in offspring, according to a new study. However, researchers…

Identification of cell types. a,b, Uniform manifold approximation and projection (UMAP) showing ~800,000 nuclei from the OFC from 87 donors colored by major cell-type cluster (a) and individual cell-type cluster (b). Cell-type annotation was performed using a label transfer algorithm,…

Microcarrier-microbioreactor setup and protocol. Credit: Journal of Translational Medicine (2024). DOI: 10.1186/s12967-024-05373-7 A new approach to manufacturing cells that secrete and deliver therapies to specific parts of the body has taken a big step toward one day repairing joints and…

Innovative technological solutions can enhance the daily lives of individuals living with aphasia, especially when people living with communication disabilities, speech and language therapy clinicians, and academics collaborate at all stages of the research process. A special issue of Advances…

Tissue resident cells differentiate S. aureus from S. epidermidis via IL-1? following barrier disruption in healthy human skin. Credit: PLOS Pathogens (2024). DOI: 10.1371 In a study recently published in PLoS Pathogens, researchers at AIMES, The Center for the Advancement…

Representative gene–gene relationship changes with age, captured by pairwise correlation and a GRN-based approach. Credit: Nature Aging (2024). DOI: 10.1038/s43587-024-00696-y Gene regulation in our cells—the decision on which proteins are produced for the various processes of the cell—is strictly regulated.…