Day December 14, 2025

Skipping sentinel lymph node biopsy (SLNB) in patients with clinically node-negative, hormonal receptor (HR)-positive, HER2-negative early-stage breast cancer did not compromise regional control or survival after a median five years of follow-up, according to results from the BOOG 2013-08 Phase…

Schematic representation of possible positions of anastomoses in the large intestine and esophagus 2: Sensor component and layer structure with the resorbable polymer PDO (polydioxanone). Credit: D. Wahl, F. Jaekel, J. Henne, et al. An interdisciplinary research team from Dresden…

Millions of Americans are bracing for soaring health care costs after the US Senate on Thursday rejected rival Republican and Democratic plans to avert the expiry of key insurance subsidies—a fight set to dominate next year’s midterm elections. President Donald…

Schematic representation of shared concepts and integrated care in epilepsy–heart syndrome. Credit: Epilepsia (2025). DOI: 10.1111 People with epilepsy are at risk for hypertension, atrial fibrillation, and hyperlipidemia; they also have an elevated risk of heart disease. Research suggests some…

Children referred to a first seizure clinic (FSC) see a neurologist epilepsy specialist within one week, according to a study presented at the annual meeting of the American Epilepsy Society, held from Dec. 5 to 9 in Atlanta. Noting that…

Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine, while placing a breathing tube, according to a randomized trial published in the New England Journal of Medicine. The “Randomized Trial…

The EPFL-Smart Kitchen-30, dataset and benchmarks. Credit: arXiv (2025). DOI: 10.48550 By transforming a kitchen into a fully instrumented research environment, a team led by EPFL neuroscientist Alexander Mathis opens a new window onto the fine-grained mechanics of human movement.…

These images show the beginnings of chromothripsis in colorectal cancer cells. The N4BP2 enzyme (green) infiltrates a micronucleus (zoomed in square selections), where it induces DNA damage (red). Blue represents the main cell nucleus. Credit: UC San Diego Health Sciences…

Overall AMD+/RPD+ compared to AMD+/RPD- study design in multiple stepwise strategies from cohort collection, GWAS, to subsequent post-GWAS analyses. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-65903-9 A new study published in Nature Communications reveals the specific genetic factors linked to the…

The United States is poised to lose its measles-free status next year. If that happens, the country will enter an era in which outbreaks are common again. More children would be hospitalized because of this preventable disease. Some would lose…

Reopening schools during the COVID-19 pandemic was linked with significantly lower rates of mental health diagnoses among children, including anxiety, depression, and attention-deficit/hyperactivity disorder (ADHD), and a drop in related health care spending, according to a new study from researchers…

A new study by a research team at Université de Montréal highlights a critical lack of knowledge about the cognitive profiles of people living with both schizophrenia and a personality disorder. A comprehensive review of scientific literature from the past…

The purplish red staining in the image shows scar tissue in the kidneys of mice. The panel on the lower left shows the most scarring. Credit: Yanling Wang Scarring is a key feature of chronic kidney disease. Now, University of…

by Javon L. Harris More than a dozen new cases of measles in the Upstate have been reported to the South Carolina Department of Public Health since the day after Thanksgiving. Fourteen new cases have been reported to the department,…

A Waymo car drives up a hill in San Francisco, Sept. 4, 2025. Credit: AP Photo/Jeff Chiu, File Self-driving Waymo taxis have gone viral for negative reasons involving the death of a beloved San Francisco bodega cat and pulling an…

by I. Edwards San Francisco is taking some of the country’s biggest food companies to court, claiming they knowingly sold ultraprocessed foods that harm health and are designed to keep people eating more. The lawsuit, announced Tuesday, argues that products…

Professor Chamindie Punyadeera. Credit: Griffith University Saliva and plasma could be crucial in detecting recurrences or relapses of head and neck cancers, negating the need for a painful and invasive biopsy. A research team from Griffith University’s Institute for Biomedicine…

Patients with hormone receptor (HR)-positive, HER2-negative advanced breast cancers had similar progression-free survival (PFS) whether they were treated with sacituzumab govitecan-hziy (Trodelvy) or standard-of-care chemotherapy as the first treatment after endocrine therapy, according to results from a Phase III ASCENT-07…

Credit: Artem Podrez from Pexels Measuring the lymphocytes—white blood cells that fight infection—in a patient’s blood can be used to predict outcomes in non-Hodgkin lymphoma patients who receive CAR T-cell therapy, according to research from physicians at Fox Chase Cancer…

Nearly a third of families with children receiving chemotherapy for acute lymphoblastic leukemia (ALL)—the most common pediatric cancer—develop serious financial difficulties during their child’s treatment, including losing 25% or more of their household income and struggling to cover the costs…

DNA, which has a double-helix structure, can have many genetic mutations and variations. Credit: NIH In a study published in Genome Research, a team of researchers, including Cornell College Assistant Professor of Biology Sophie Gillett, looked at regions of human…

Credit: Sora Shimazaki from Pexels Many patients with inflammatory bowel disease (IBD) suffer from abdominal pain even between acute inflammatory flare-ups. Altered processing of pain in response to fear may be involved. This is the conclusion of a research team…

A microscopic image of the Hepatitis B virus, taken by the Centers for Disease Control and Prevention Working out of a tribal-owned hospital in Anchorage, Alaska, liver specialist Brian McMahon has spent decades treating the long shadow of hepatitis B.…

A night-shift worker finishes at dawn. Their phone says Tuesday, but their body feels like it’s Monday. The body’s internal clock, or circadian rhythm, controls physiological processes such as sleeping, eating and physical activity, taking its cues from the daily…

Organoids from NPp53 mice recapitulate heterogeneity and neuroendocrine transdifferentiation of CRPC-NE. Credit: Nature (2025). DOI: 10.1038/s41586-025-09727-z Scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) have discovered a key mechanism that makes prostate cancer cells resistant to the latest drugs…

Outline of recombinant human norovirus generation using zebrafish embryos. Credit: Takeshi Kobayashi (Created with Biorender.com) Norovirus is the leading cause of gastroenteritis and is responsible for hundreds of thousands of deaths every year. However, research progress into antiviral treatments and…

A major study investigating the diagnosis and outcomes of more than 400,000 people with heart failure over the past 20 years has found that diagnostic investigations in primary care were below guideline standards. The study, carried out by Leicester researchers,…

Intrusive thoughts and psychotic-like experiences among new parents are far more common than previously thought—according to new research from the University of East Anglia. The study published today in the Community Mental Health Journal reveals the mental health challenges faced…

Tammie Lee Demler, PharmD, a board-certified psychiatric pharmacist who works at a Buffalo inpatient psychiatric practice site, is all too familiar with the stigmas and misconceptions facing people with mental illness. And it’s an issue she’s doing her part to…

A landmark report led by La Trobe University has unveiled the true scale of damage caused by alcohol in Australia. “Alcohol’s Harm to Others in Australia: Patterns, Costs, Disparities and Precipitants” was compiled over six years and is the most…

Credit: Anna Tarazevich from Pexels A new Curtin University study has found that people diagnosed with sarcoma—a cancer disproportionately affecting teenagers and young adults—are being left without the resources they urgently need. Sarcoma is a rare and complex cancer in…

Schematic representation of the Gx Sweat Patch (Gatorade, USA) for sweat monitoring. Credit: Journal of Pharmaceutical Analysis (2025). DOI: 10.1016 Sweat contains a wealth of biological information that, with the help of artificial intelligence and next-generation sensors, could transform how…

Credit: JACC: CardioOncology (2025). DOI: 10.1016 A surprising new discovery by Prof. Ami Aronheim and his team at the Technion–Israel Institute of Technology shows that in the absence of anti-cancer treatments, cancer development may actually improve heart function and reduce…

Vaccination with the IgE kinoid (IgEK) reduces extravasation during IgE-mediated cutaneous anaphylaxis in mice. Credit: Dr. William Worrall Researchers led by the Institut Pasteur, Université Paris, have developed a vaccine that elicits anti-Immunoglobulin E antibodies in humanized mice, protects against…

New three-year follow-up results from the TRANSCEND FL trial show that patients with relapsed or refractory follicular lymphoma can achieve durable, multi-year remission with chimeric antigen receptor (CAR) T cell therapy, even after prior treatments have failed, according to researchers…

Recording of brain activity using EEG. Credit: LMU / Johanna Weber First and foremost, we breathe in order to absorb oxygen—but this vital rhythm could also have other functions. Over the past few years, a range of studies have shown…

Sensitive tests designed to detect very small numbers of remaining leukemia cells after treatment, known as measurable residual disease (MRD), may provide an early and reliable indicator of long-term outcomes for patients with acute myeloid leukemia (AML), according to a…

Over-reliance on generative AI risks eroding new and future doctors’ critical thinking skills, while potentially reinforcing existing data bias and inequity, warns an editorial published in the online journal BMJ Evidence Based Medicine. GenAI tools are already being widely used…

A new study shows that giving the chemotherapy drug cyclophosphamide after allogeneic hematopoietic cell transplantation, a curative treatment for common types of blood cancer, can make the procedure safe and effective even when donors and recipients are unrelated and have…

Hemorrhoids are a common condition that affects about half of all people by age fifty. Although hemorrhoids are usually harmless, some worry that they may be a sign of cancer. While certain symptoms of hemorrhoids, colorectal cancer, and anal cancer…