|Generic Name||Brand Name|
|brimonidine and timolol||Combigan|
These medicines are given in eyedrop form. A commonly used adrenergic agonist (brimonidine tartrate) eyedrop has a purple bottle cap. If you need to use more than one type of eyedrop, you may need to take each medicine in a certain order. You can use the colour of the bottle cap to help you remember when to use each type of eyedrop.
If you are using more than one type of eyedrop, wait 5 minutes between the different eyedrop medicines.
Most adrenergic agonists reduce the pressure in the eyes by reducing how much fluid (aqueous humour) the eyes produce. They also increase the amount of fluid that drains out of the eyes.
These medicines may be used along with other medicines to treat glaucoma.
Brimonidine is used to treat high pressure in the eyes in people with open-angle glaucoma. It is also used to prevent high pressure in an eye after laser treatment for glaucoma.
Epinephrine is rarely used since brimonidine is just as effective with fewer side effects.
These medicines reduce the pressure in the eyes. Reducing the pressure in the eyes reduces the chances of damage to the optic nerve, preventing further vision loss.
Side effects of adrenergic agonists include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
Brimonidine should not be used if a person is taking a monoamine oxidase inhibitor (MAOI), used to treat depression. People who are taking tricyclic antidepressants and those with severe heart, liver, or kidney disease may not be able to take this medicine.
Epinephrine drops tighten (constrict) the blood vessels on the eye's surface, taking the red out of the white part of the eye. After 2 to 3 hours, the vessels open (dilate) and the eye becomes red again. People may be tempted to overuse this medicine to keep the red out of their eyes.
Brimonidine may cause allergy problems in some people when used over a long period of time.
Last Revised: April 2, 2012
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.