Anemia, Hemolytic, Warm Antibody

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Anemia, Hemolytic, Warm Antibody

National Organization for Rare Disorders, Inc.

It is possible that the main title of the report Anemia, Hemolytic, Warm Antibody is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • Warm Reacting Antibody Disease
  • Idiopathic Warm Antibody Hemolytic Anemia
  • Primary Warm Antibody Hemolytic Anemia
  • Warm Antibody Autoimmune Hemolytic Anemia

Disorder Subdivisions

  • Warm Autoimmune Hemolytic Anemia secondary to IgM Autoantibodies
  • Warm-reactive AIHA secondary to IgM

General Discussion

Warm antibody hemolytic anemia is an autoimmune disorder characterized by the premature destruction of healthy red blood cells by autoantibodies. Autoimmune diseases occur when the body's natural defenses against foreign organisms (e.g., lymphocytes, antibodies) destroy healthy tissue for unknown reasons. Normally, red blood cells have a life span of approximately 120 days before they are removed by the spleen. The medical term for low levels of circulating red blood cells is anemia. Anemia may cause fatigue, a pale skin color (pallor), yellowing of the skin and whites of the eyes (jaundice) and the passage of blood in the urine (hemoglobinuria), which gives the urine a dark brown color. Warm antibody hemolytic anemia is classified as an autoimmune hemolytic anemia (AIHA), an uncommon group of disorders in which the immune system mistakenly attacks healthy red blood cells.


NIH/National Heart, Lung and Blood Institute
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MUMS National Parent-to-Parent Network
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Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223

Anemia Institute for Research and Education
151 Bloor Street West, Suite 600
Toronto Ontario, M5S 1S4
Tel: 416-969-7431
Fax: 416-969-7420
Tel: 877-992-6364

Cold Agglutinin Disease E-Support
c/o Betty Usdan
146 Greens Rd.
Hollywood, FL 33021
Tel: (954)961-2703
Fax: (954)961-2703

AutoImmunity Community
Tel: (919) 552-9057

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

Last Updated:  3/11/2008
Copyright  1990, 2000, 2008 National Organization for Rare Disorders, Inc.

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