It is possible that the main title of the report Acquired Aplastic Anemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Acquired aplastic anemia is a rare disorder caused by profound, almost complete bone marrow failure. Bone marrow is the spongy substance found in the center of the long bones of the body. The bone marrow produces specialized cells (hematopoietic stem cells) that grow and eventually develop into red blood cells (erythrocytes), white blood cells (leukocytes), and platelets. In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells eventually results in low levels of red and white blood cells and platelets (pancytopenia). Specific symptoms associated with acquired aplastic anemia may vary, but include fatigue, chronic infections, dizziness, weakness, headaches, and episodes of excessive bleeding. Although some cases of acquired aplastic anemia occur secondary to other disorders, researchers now believe that most cases result from a disorder of the patient's immune system, in which the immune system mistakenly targets the bone marrow (autoimmunity). This is based on the response of approximately half of patients to immunotherapy, whether it is ATG, cyclosporine, high-dose steroids or cyclophosphamide.
Aplastic Anemia & MDS International Foundation, Inc.
100 Park Avenue, Suite 108
Rockville, MD 20850
NIH/National Heart, Lung and Blood Institute
P.O. Box 30105
Bethesda, MD 20892-0105
Aplastic Anemia & Myelodysplasia Association of Canada
11181 Yonge Street Suite 321
Canada, Intl L4S 1L2
Tel: (905) 780-0698
Fax: (905) 780-1648
Tel: (888) 840-0039
NIH/National Heart, Lung and Blood Institute ~ Hematology Branch
10 Center Dr, Building 10-CRC
Bethesda, MD 20892-1202
Dubowitz Syndrome Support
c/o 106 Verndale Street
Warwick, RI 02889-3242
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
PO Box 241956
Los Angeles, CA 90024
Anemia Institute for Research and Education
151 Bloor Street West, Suite 600
Toronto Ontario, M5S 1S4
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 4/27/2009
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