Diabetes: Urine Tests for Protein

Search Knowledgebase

Topic Contents

Diabetes: Urine Tests for Protein

Topic Overview

Protein normally is not found in urine. When the kidneys are damaged by diabetes, small amounts of protein begin to leak into the urine. If blood sugar levels stay high and early kidney damage is left untreated, larger amounts of protein may be lost, possibly leading to kidney failure.

Urine tests for protein levels in people with diabetes check for amounts of albumin (protein). A urine test for protein can be done on a sample of urine collected randomly (usually the first time you urinate in the morning), a sample collected over 24 hours, or a sample collected over a specific period, such as 4 hours or overnight.

No preparation is needed for this test, but results can be affected by factors such as high blood sugar levels, recent exercise, urinary tract infections, high blood pressure, heart failure, or a high fever during an infection.

Abnormal results differ slightly among the three different types of urine samples.1

Abnormal urine test results
Results 24-hour urine sample Timed urine sample Random urine sample
  Milligrams of protein per 24 hours Micrograms of protein per minute Micrograms of protein per milligram of creatinine


Less than 30

Less than 20

Less than 30

Tiny amounts of protein (microalbuminuria)




High protein (macroalbuminuria)

300 or more

200 or more

300 or more

Because the amount of protein lost through urine varies, 2 of 3 urine samples within a 3- to 6-month period need to show abnormal results for a diagnosis of diabetic kidney disease (nephropathy).



  1. American Diabetes Association (2004). Nephropathy in diabetes. Clinical Practice Recommendations 2004. Diabetes Care, 27(Suppl 1): S79–S83.


By Healthwise Staff
Primary Medical Reviewer John Pope, MD - Pediatrics
Primary Medical Reviewer Andrew Swan, MD, CCFP, FCFP - Family Medicine
Specialist Medical Reviewer Stephen LaFranchi, MD - Pediatrics, Pediatric Endocrinology
Last Revised September 24, 2010

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.