Antidepressant medicines, which are usually used to treat depression, can be effective in preventing migraine headaches. Antidepressants have some pain-relieving properties and may reduce duration and frequency of headaches. Antidepressants are also used to improve sleep problems.
Other tricyclic antidepressants may be tried if you do not respond well to amitriptyline or nortriptyline. The choice of antidepressant to treat your migraines may depend on your ability to tolerate the side effects of the medicine.
Side effects of tricyclic antidepressants include:
Health Canada and the U.S. Food and Drug Administration (FDA) have issued advisories on antidepressant medicines and the risk of suicide. It is not recommended that people stop using these medicines. Instead, a person taking antidepressants should be watched for warning signs of suicide. This is especially important at the beginning of treatment or when the doses are changed.
|Primary Medical Reviewer||Anne C. Poinier, MD - Internal Medicine|
|Specialist Medical Reviewer||Colin Chalk, MD, CM, FRCPC - Neurology|
|Last Revised||July 20, 2011|
Last Revised: April 20, 2012
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