Hyperthyroidism: Graves' Ophthalmopathy

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Hyperthyroidism: Graves' Ophthalmopathy

Topic Overview

In Graves' ophthalmopathy the tissues and muscles behind the eyes become swollen. The eyeballs may stick out farther than normal. This can occur before, after, or at the same time as other signs of hyperthyroidism.

See a picture of Graves' ophthalmopathy.

Most people who develop Graves' ophthalmopathy have one or more of the following symptoms:

  • Dry, itchy, irritated eyes
  • A staring or bug-eyed look
  • Sensitivity to light; watery, teary eyes; and a feeling of pain or pressure around the eyes
  • Difficulty closing the eyes completely
  • Double vision, especially when looking to the sides

A small number of people have symptoms because the tissues around their eyes are inflamed (acute inflammatory thyroid eye disease). These symptoms include:

  • Swelling of the eyelids and tissues around the eyes, especially in the morning.
  • Swelling of the membrane that covers the eyeball and lines the eyelid.
  • Pain when moving the eyes up and down and from side to side.

Most mild problems caused by Graves' ophthalmopathy go away on their own in 1 to 4 months. Graves' ophthalmopathy may also get better if you take antithyroid medicine.

You will likely have an eye examination to make sure you do not have another eye problem, such as a tumour.

To help reduce dryness and discomfort, your doctor will treat your symptoms of Graves' ophthalmopathy. He or she will use artificial tears, medicated eyedrops, and protective glasses or sunglasses. If the condition is diagnosed early, you can use non-steroidal anti-inflammatory drugs (NSAIDs), such as ASA, ibuprofen, and naproxen, to relieve pain and inflammation.

If you have severe inflammation of the muscles and tissues around your eyes, you may need corticosteroid medicines, immunosuppressants, or radiation therapy. Surgery is only done if you have serious vision problems or nerve damage, or if you want to change the way your eyes look.

Ophthalmopathy may get worse if your thyroid levels are out of balance. It may also get worse temporarily if you are given radioactive iodine therapy.

Smoking increases your chances of developing Graves' ophthalmopathy. And it can make the condition worse.


By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer Matthew I. Kim, MD - Endocrinology
Specialist Medical Reviewer Andrew Swan, MD, CCFP, FCFP - Family Medicine
Last Revised February 5, 2010

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