Peptic Ulcers and Nonsteroidal Anti-Inflammatory Drugs

Search Knowledgebase

Topic Contents

Peptic Ulcers and Nonsteroidal Anti-Inflammatory Drugs

Topic Overview

It is not clear how non-steroidal anti-inflammatory drugs (NSAIDs) damage the stomach's lining, sometimes causing an ulcer. The following are the two likely ways this may happen:

  • Use of NSAIDs may directly irritate the stomach's lining, making it easier for ulcers to form.
  • NSAIDs may interfere with prostaglandins, which are chemicals that may help regulate the protective lining of the stomach.

It is also possible that both of these factors occur at the same time.

About 15 to 20 out of 100 people who use high doses of NSAIDs, such as people who have rheumatoid arthritis or osteoarthritis, develop sores in the stomach that look like ulcers when examined with endoscopy.1 But only a small number actually develop symptoms or complications of peptic ulcer disease. Serious complications of peptic ulcer disease caused by NSAID use are higher in people who:1

  • Have a prior history of abdominal (belly) problems, such as an ulcer or bleeding.
  • Are older than age 65.
  • Take high doses of NSAIDs.
  • Use corticosteroids in addition to NSAIDs.
  • Have infection with Helicobacter pylori (H. pylori) bacteria.
  • Just started to take NSAIDs every day.
  • Use ASA, even in low daily doses.
  • Use blood thinners (anticoagulants) such as warfarin (Coumadin) or antiplatelet medicines such as clopidogrel (Plavix) or ticlopidine, especially when used in addition to NSAIDs or low-dose ASA.

You can prevent NSAID ulcers and their complications by not taking NSAIDs or by only taking them occasionally and in small doses. If you have to use NSAIDs, your doctor may advise you to take an NSAID that is less likely to cause ulcers. Or your doctor may prescribe a medicine that you take each day to help prevent ulcers. Medicines that help prevent ulcers include:

  • Proton pump inhibitors (such as omeprazole).
  • Prostaglandin analogs (such as misoprostol).
  • H2 blockers (such as famotidine).

Your doctor may advise you to get tested for H. pylori bacteria before you start long-term NSAID use. Testing and treatment for H. pylori infection has been shown to reduce the risk of ulcers for people starting long-term NSAID use.1 If you take NSAIDs, be sure to discuss with your doctor the potential risks of long-term NSAID use.

Related Information



  1. Lanza FL, et al. (2009). Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology, 104(3): 728–738.


By Healthwise Staff
Primary Medical Reviewer Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
Last Revised February 25, 2010

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.