Necrotizing Enterocolitis

Search Knowledgebase

Topic Contents

Necrotizing Enterocolitis

Overview

What is necrotizing enterocolitis?

Necrotizing enterocolitis is infection and inflammation of the intestine. It is most common in babies who are born early (premature). Many newborns who have it go on to live healthy lives. But if the infection becomes severe, it can cause severe damage to the intestine, which can be deadly. Some children may have ongoing problems with digestion, growth, or development.

This condition usually happens within the first 2 weeks after birth. But it may occur up to 3 months after birth.

See a picture of necrotizing enterocolitis.

What causes necrotizing enterocolitis?

Doctors aren't sure what causes this condition. It may occur when the immune and digestive systems do not form in the right ways. This can happen when a baby is born early or when there are problems during pregnancy or delivery.

Experts don't know if feeding formula to a newborn can lead to necrotizing enterocolitis. They do know that the disease is much less common in babies who are fed breast milk.

What are the symptoms?

Symptoms depend on how severe the problem is. They may include:

  • A swollen, tender, red, or shiny belly.
  • Constipation.
  • Dark, black, or bloody stools.
  • Low or unstable body temperature.
  • Chills and fever.
  • Fast heartbeat and breathing.
  • Not wanting to eat.
  • Vomiting.
  • Being less active or having little energy.

How is necrotizing enterocolitis diagnosed?

The doctor will ask about your baby’s symptoms and past health. The doctor may do tests, such as:

  • An X-ray of your newborn’s belly.
  • A test to check for blood in your baby’s stool (fecal occult blood test).
  • Tests to check for bacteria in the stool, blood, urine, or spinal fluid.

How is it treated?

Your baby will be treated in a hospital neonatal intensive care unit (NICU). Treatment usually lasts 3 to 10 days. It may last longer if the condition is severe. Treatment includes intravenous (IV) feeding, antibiotics, and a tube that goes in the nose to the stomach to remove extra fluids and gas from the intestine.

If your baby does not get better with treatment or gets a hole in the intestine, he or she may need surgery. About 1 out of 4 babies who have necrotizing enterocolitis needs surgery.1 Surgery usually means having two procedures weeks or months apart. The first surgery removes damaged parts of the intestine and may create a colostomy or ileostomy so that the intestine can heal. (With an ostomy, stool leaves the body through an opening in the belly and collects in a bag.) A second surgery will be done to close the ostomy so that stool can pass through the body normally again.

After treatment, your baby will be ready to leave the hospital when he or she is eating well and is not losing weight. The nurse can show you how to feed and care for your baby at home.

It is normal to feel overwhelmed when your baby has health problems. It can be stressful to watch a tiny newborn get medical treatment. You may feel frustrated if you can't hold your baby as often as you want or can't breast-feed your baby. It may help to talk about your feelings and concerns with a social worker or counsellor. Be sure to ask your baby’s doctors about anything you don't understand.

Health Tools Health Tools help you make wise health decisions or take action to improve your health.

Health Tools help you make wise health decisions or take action to improve your health.


Actionsets help people take an active role in managing a health condition. Actionsets are designed to help people take an active role in managing a health condition.
  Bowel Disease: Caring for Your Ostomy

Other Places To Get Help

Organizations

Canadian Paediatric Society
2305 Saint Laurent Boulevard
Ottawa, ON  K1G 4J8
Phone: (613) 526-9397
Fax: (613) 526-3332
Email: info@cps.ca
Web Address: www.cps.ca
 

The Canadian Paediatric Society (CPS) promotes quality health care for Canadian children and establishes guidelines for paediatric care. The organization offers educational materials on a variety of topics, including information on immunizations, pregnancy, safety issues, and teen health.


KidsHealth for Parents, Children, and Teens
4600 Touchton Road East, Building 200
Suite 500
Jacksonville, FL  32246
Phone: (904) 232-4100
Fax: (904) 232-4125
Web Address: www.kidshealth.org
 

This Web site is sponsored by Nemours Foundation. It has a wide range of information about children's health, from allergies and diseases to normal growth and development (birth to adolescence). This Web site offers separate areas for kids, teens, and parents, each providing age-appropriate information that the child or parent can understand. You can sign up to get weekly e-mails about your area of interest.


March of Dimes
1275 Mamaroneck Avenue
White Plains, NY  10605
Phone: (914) 997-4488
Web Address: www.marchofdimes.com
 

The March of Dimes tries to improve the health of babies by preventing birth defects, premature birth, and early death. March of Dimes supports research, community services, education, and advocacy to save babies' lives. The organization's Web site has information on premature birth, birth defects, birth defects testing, pregnancy, and prenatal care. You can sign up to get a free newsletter and also explore Understanding Your Newborn: An Interactive Program for New Parents.


Related Information

References

Citations

  1. Thilo EH, Rosenberg AA (2011). Necrotizing enterocolitis section of The newborn infant. In WW Hay Jr et al., eds., Current Diagnosis and Treatment: Pediatrics, 20th ed., pp. 36–37. New York: McGraw-Hill.

Other Works Consulted

  • Piazza AJ, Stoll BJ (2007). Digestive system disorders. In RM Kliegman et al., eds., Nelson Textbook of Pediatrics, 18th ed., pp. 753–756. Philadelphia: Saunders Elsevier.
  • Brown RE, Neu J (2006). Necrotizing enterocolitis. In FD Burg et al., eds., Current Pediatric Therapy, 18th ed., pp. 293–296. Philadelphia: Saunders Elsevier.
  • Cincinnati Children's Hospital Medical Center (2007). Evidence-based care guidelines for necrotizing enterocolitis (NEC) among very low-birth-weight infants. Available online: http://www.cincinnatichildrens.org/assets/0/78/1067/2709/2777/2793/7585a353-7c3e-400f-98a6-91c6b63232fc.pdf.
  • Mohan P, Abrams SA (2009). Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates. Cochrane Database of Systematic Reviews (1).
  • Pietz J, et al. (2006). Prevention of necrotizing enterocolitis in preterm infants: A 20-year experience. Pediatrics, 119(1): e164–e170.
  • Solomkin JS, et al. (2010). Diagnosis and management of complicated intra-abdominal infection in adults and children: Guidelines by the Surgical Infection Society and the Infection Society and the Infectious Diseases Society of America. Clinical Infectious Diseases, 50(2): 133–164. [Erratum in Clinical Infectious Diseases, 50(12): 1695.]
  • Venkatesh MP, Abrams SA (2010). Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database of Systematic Reviews (5).

Credits

By Healthwise Staff
Primary Medical Reviewer Sarah Marshall, MD - Family Medicine
Primary Medical Reviewer Donald Sproule, MD, CM, CCFP, FCFP - Family Medicine
Specialist Medical Reviewer Jennifer Merchant, MD - Neonatal-Perinatal Medicine
Last Revised June 28, 2011

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.