Cirrhosis: Vasoconstrictor Medicines for Variceal Bleeding

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Cirrhosis: Vasoconstrictor Medicines for Variceal Bleeding

Topic Overview

Medicines that constrict small blood vessels and reduce blood flow to the portal vein are used to treat sudden (acute) bleeding from enlarged veins (varices) in the digestive tract (variceal bleeding).

Octreotide is the main medicine used in North America to treat variceal bleeding.

These medicines also may be used along with endoscopic treatment. Adding medicine to endoscopic treatment works better to control bleeding than endoscopic treatment alone.1

Side effects of these medicines may include:

  • Irregular heartbeats (arrhythmias).
  • Headache.
  • Dizziness.
  • Too much sugar in the blood (hyperglycemia).
  • Diarrhea.
  • Formation of gallstones (with long-term use).

Related Information

References

Citations

  1. Garcia-Tsao G, et al. (2007). Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. American Journal of Gastroenterology, 102(9): 2086–2102.

Credits

By Healthwise Staff
Primary Medical Reviewer Kathleen Romito, MD - Family Medicine
Primary Medical Reviewer Brian D. O'Brien, MD - Internal Medicine
Specialist Medical Reviewer W. Thomas London, MD - Hepatology
Last Revised June 7, 2010

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