Nifedipine and diltiazem are calcium channel blockers.
These medicines, which are taken by mouth (orally) to lower blood pressure, have been found to have some benefit in healing long-term (chronic) tears, or fissures in the anus.
A review of many studies showed that calcium channel blockers were no better at healing anal fissures than nitroglycerin ointment. More research needs to be done on how well calcium channel blockers can help anal fissures heal.
cause of fissures is increased tension (called resting pressure) and spasm in
the internal anal sphincter, one of two muscles that control the anus. These
medicines work by relaxing the smooth muscle, allowing the fissure to