Mitotane may cause a serious, life-threatening condition that can occur when not enough hormone (cortisol) is produced by the adrenal glands in your body. Mitotane must be taken under the supervision of a doctor who has experience in using medications to treat cancer. If you develop a severe infection, illness, or injury you should stop taking mitotane and call your doctor immediately.
Mitotane is used to treat cancer of the adrenal gland that can not be treated with surgery. Mitotane is in a class of medications called antineoplastic agents. It works by slowing growth or reducing the size of the tumor.
Mitotane comes as a tablet to take by mouth. It is usually taken three to four times a day. Take mitotane at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mitotane exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
You will probably be hospitalized when you begin your treatment with mitotane. Your doctor will start you on a low dose of mitotane and gradually increase your dose.
Continue to take mitotane even if you feel well. Do not stop taking mitotane without talking to your doctor.
Mitotane is also sometimes used to treat Cushing's Syndrome (condition where the body produces too much of the hormone cortisol). Talk to your doctor about the risks of using this drug for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Unless your doctor tells you otherwise, continue your normal diet.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
loss of appetite
nausea
vomiting
diarrhea
depression
lack of energy
unusual drowsiness
feeling that the room is spinning
changes in vision
rash or changes in skin color
abdominal or side pain
confusion
fast heartbeat
high fever or shaking chills
excessive sweating
Mitotane may cause brain or nervous system damage when taken at high doses for longer than 2 years. Talk to your doctor about the risks of taking this medication.
Mitotane may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to mitotane.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking mitotane.
Wear or carry medical identification stating that you take mitotane to be sure you get proper treatment in an emergency.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 04/01/2012
AHFS® Consumer Medication Information. © Copyright, 2012. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.