Hypogonadotropic hypogonadism

Hypogonadism is when the sex glands produce little or no hormones. In men, these glands (gonads) are the testes. In women, they are the ovaries.

Hypogonadotropic hypogonadism is a form of hypogonadism that is due to a problem with the pituitary or hypothalamus glands. These glands are found in or near the brain.

See also: Hypogonadism


Normally, the hypothalamus in the brain releases gonadotropin-releasing hormone (GnRH). This hormone stimulates the pituitary gland to release other hormones, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Normally, these hormones tell the female ovaries and male testes to release hormones that lead to normal sexual development in puberty.

  • Before puberty, any change in this hormone release chain causes a lack of sex hormones and prevents normal sexual maturity.
  • If the problem occurs after puberty, sexual development may be normal, but there may be symptoms of low sex hormones (such as symptoms of menopause in women and sexual dysfunction in men).

Kallmann syndrome is an inherited form of hypogonadotropic hypogonadism that can occur with a loss of smell.


  • Erectile dysfunction in men
  • Inability to smell (in some cases)
  • Lack of development at puberty (development may be incomplete or delayed)
  • Lack of secondary sexual characteristics such as pubic, facial, and underarm hair
  • Loss of menstrual periods in women
  • Short stature (in some cases)
  • Underdeveloped testicles

Exams and Tests

Tests that may be done include:


Treatment depends on the source of the problem, but may involve:

  • Estrogen and progesterone pills
  • GnRH injections
  • Injections of testosterone
  • Slow-release testosterone skin patch
  • Surgery to remove a pituitary tumor
  • Testosterone gels

Outlook (Prognosis)

With the right hormone treatment, the person can go through puberty and fertility may be restored.

Possible Complications

  • Delayed puberty
  • Infertility
  • Low self-esteem due to late start of puberty (emotional support may be helpful)
  • Sexual dysfunction

When to Contact a Medical Professional

Call your health care provider if your child does not enter puberty as expected.


Prevention depends on the cause.

People who have a family history of inherited conditions that cause hypogonadism may benefit from genetic counseling. Preventing serious head injuries reduces the risk of hypogonadotropic hypogonadism due to pituitary injury.

Alternative Names

Gonadotropin deficiency; Secondary hypogonadism; Kallmann syndrome


Styne DM, Grumbach MM. Puberty: Ontogeny, neuroendocrinology, physiology, and disorders. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier;2011:chap 25.

Update Date: 4/26/2012

Reviewed by: Nancy J. Rennert, MD, Chief of Endocrinology & Diabetes, Norwalk Hospital, Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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