Acquired platelet function defects are diseases or conditions that cause the blood elements needed for blood clotting (platelets) to not work properly. The term "acquired" means these diseases or conditions are not present at birth.
With platelet disorders, there may be too many or too few platelets, or platelets that do not function well. Some conditions cause changes in both the number and function of platelets. Any platelet disorder affects blood clotting.
These disorders can be present at birth (congenital), or they may develop later because of another disease or condition, or without a known cause. In many cases, the platelet count may be normal or even high, but there will be evidence of a bleeding disorder.
Disorders that can cause problems in platelet function include:
Other causes include:
Treatment is aimed at the cause of the problem.
Treating the cause of the problem usually corrects the defect.
Call your health care provider:
Using medications carefully can reduce the risk of drug-related acquired platelet function defects. Treating other disorders may also reduce the risk. Some cases are not preventable.
Acquired qualitative platelet disorders; Acquired disorders of platelet function
Lopez JA, Lockhart E. Acquired disorders of platelet function. In: Hoffman R, Benz EJ, Jr, Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier;2008:chap 142.
McMillan R. Hemorrhagic disorders: Abnormalities of platelet and vascular function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 179.
Reviewed by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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