HMN 2025: Fetal Bio Marker about the danger of Alzheimer’s disease

Alzheimer’s disease (AD) is a terrible possibility that it will become more and more common when the population comes out. The biological cause of the disease (the accumulation of the brain’s plaques) is understood, but some people develop disability and others are still mystery. Unfortunately, many believe that AD is inevitable as AD is older. In fact, this is not true. According to the Ministry of Health and Welfare and the CDC, only 4%of adults aged 65 or older have been diagnosed with dementia in 2022 (more than 100 people are known as the Alzheimer’s International or ADI organization: AD is the most known dementia). Dementia diagnostic ratios increase according to age, but only 7%of age or older are diagnosed with dementia (National Health Statistics Reports, 2024).

The development of age is the most powerful predictor of AD, but there are other factors that work. For example, even the level of educational levels achieved compared to family income, large -scale residence, small or rural areas seems to be an important factor in diagnostic risks. As with other danger factors, the role of gender is applied with the effect of increasing age and the role of gender. Some studies have shown that women are more likely to be diagnosed with AD than men, but at the same time, women tend to live longer than men, so it is difficult to harass the role of gender. The same CDC report showed that men and women aged 65 or older reported the same diagnostic rate as dementia.

A method of helping a doctor predicts a person who is at risk of AD development is effective and more effective. This finds biomarkers (molecules that can be found objectively, reliably, stable, stable in blood, body fluids or tissues, and can act as a sign of an abnormal state or a disease such as AD) (STRIMBU and PAVEL, 2010). Some researchers are known to have recently found biomarkers for AD and biomarkers that can be tracked as events in the uterus.

AD patients often increase the level of inflammatory cytokine. Saito Cain is a protein that tells the immune system what to do. Full inflammatory cytokine stimulates the immune system (others slow down). Neuroma (activation of the immune response of the brain) is a series of events that can lead to various changes in the body according to the affected brain region It leads. “Disease reaction behavior…[like] Heat, anhedonia, hypophagia, hypersomnia, hypersomnia, hypergesia, social behavior and cognitive deficit reduction, not lack of memory (Hein and O’banion, 2009, Page 2).

Since memory loss is closely related to AD and nerve inflammation, Goldstein et al. (2024) was looking for biomarkers to predict the risk of developing AD in unique people groups. Their participants were recruited by the New England Family Research (NEFS), which tracked participants from the fetus (between 1959 and 1966) to the present and continued to continue to date. Goldstein and her colleagues obtained medical records and maternal blood samples from the current business owners of the two groups. In one group, the mother experienced a limitation of liver prevalence and/or fetal growth during pregnancy. Both complications are associated with the problem of blood flow in parent hypertension and placenta. Both are known to activate the mother’s immune system, which causes neuromosal inflammation in the developed fetuses. The second participant group was not exposed to the inner Cain in the uterus.

Goldstein et al. About 50 years after birth, in a review of memory and brain, we investigated the fetal exposure effect on cytokine. They hypothesized that at the beginning of the third quarter of pregnancy, exposure to the maternal inflammatory cytokine, the main time for sexual differentiation of the brain, will have a gender -dependent effect on the memory and immune system function of the descendants. Lifetime. “(Goldstein, et al., 2024, page 1).

They found that fetal exposure to inflammatory cytokine is significantly related to the gender difference in brain activity and the connectivity of the brain memory circuit. In addition, performance was lowered in the memory work of the group exposed to Saito Cain compared to the unpositive group. In male, as exposure to inflammatory cytokine in the uterus rose, it was associated with reducing the memory of the frontal lobe and the hippocampus and low activities. After menopause, higher fetal cytokine levels are associated with decreased memory performance and changes in women’s memory circuit functions.

It is not surprising that maternal immune function and maternal health can affect the developed fetus. But Goldstein points out that the environment of the uterus is not the only factor here. “There are many environmental effects that affect brain and physiology during the life of life, creating elasticity and breaking the effect of initial exposure on memory. ” Page 7). Consider other factors that affect the risk of advertising to other factors, such as socioeconomic status. The story is not over yet.