Predictors of chronic kidney disease (CKD) include age and hematologic disease length after hematopoietic stem cell transplantation (HSCT), according to a study published online Aug. 4 in Renal Failure.
Alina Tanase, M.D., Ph.D., from Fundeni Clinical Institute in Bucharest, Romania, and colleagues prospectively assessed a cohort of 197 patients (mean age, 38.7 years; 52.8% female) who underwent allogeneic HSCT to explore the incidence and risk factors associated with CKD.
Overall, acute kidney injury was present in 80% of patients within three months, and CKD incidence was 11.7% (median onset, six months). The researchers found that age (per year) was the only variable associated with CKD by univariate Cox regression analysis (hazard ratio [HR], 1.06); a trend of association was presented for baseline creatinine (per 1 mg/dL). Positive predictors for CKD included age (per year; HR, 1.08) and hematologic disease length (per month; HR, 1.01) in a multivariate Cox regression analysis. Acute lymphoblastic leukemia was a negative predictive factor (HR, 0.37).
“Given the continuously improving oncologic prognosis of these patients, CKD is becoming a challenge in the long-term care after HSCT, compelling for a multidisciplinary approach,” the authors write.
More information:
Alina Tanase et al, Incidence and risk factors for chronic kidney disease after hematopoietic stem cell transplantation, Renal Failure (2025). DOI: 10.1080/0886022X.2025.2535517
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Age and disease duration are predictors of chronic kidney disease after stem cell transplant ( 12)
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