As interest in psychedelics surges across the United States, a new study led by researchers at the University of Michigan and the University at Buffalo offers critical harm-reduction guidance for individuals considering their first psychedelic experience.
Published in the Harm Reduction Journal, the study represents the first large-scale, community-based effort to crowdsource practical recommendations from experienced psychedelic users. The research team surveyed 581 individuals with psychedelic experience, analyzing recommendations for substances, combinations, and practical advice.
Key findings
- Psilocybin mushrooms were the most recommended substance for first-time use, favored for their moderate intensity and predictable effects.
- Cannabis and MDMA/MDA were also commonly suggested, while substances such as ayahuasca, 5-MeO-DMT, and Salvia divinorum were discouraged due to their intensity and safety concerns.
- Advice included avoiding combinations with alcohol, stimulants, and antidepressants.
- Participants emphasized mental preparation, safe environments, and starting with low doses, and ensuring trusted companions or guides are present as essential harm-reduction practices.
With psychedelic use at historic highs and legal therapeutic access still limited, many individuals are navigating these experiences without formal guidance. This study fills a critical gap by providing experience-informed recommendations to reduce risks and enhance positive outcomes. The study underscores the importance of preparation, environment, and informed decision-making for minimizing risks.
“Given the growing interest in psychedelics and the lack of systematic education and regulation, it is vital to share harm-reduction practices that promote safety and well-being,” said Dr. Daniel Kruger, Principal Investigator. “Our findings highlight the value of community knowledge in guiding those considering psychedelic use for the first time.”
More information
Daniel J. Kruger et al, Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community, Harm Reduction Journal (2025). DOI: 10.1186/s12954-025-01337-2
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