Measuring eGFR based on cystatin C levels may be a more accurate assessment of kidney function in older adults

As individuals age, the risk of developing kidney disease increases. It is crucial to accurately assess kidney function in older adults to provide appropriate medical care. Traditionally, estimated glomerular filtration rate (eGFR) has been used as a measure of kidney function. However, recent studies suggest that measuring eGFR based on cystatin C levels may provide a more accurate assessment, especially in older adults.

What is eGFR?

eGFR is a measure of how well the kidneys filter waste products from the blood. It is calculated using a formula that takes into account factors such as age, sex, race, and serum creatinine levels. eGFR is widely used to diagnose and stage kidney disease.

The limitations of eGFR in older adults

While eGFR is a valuable tool, it has certain limitations, particularly in older adults. One major limitation is that eGFR is influenced by muscle mass, which tends to decrease with age. As a result, eGFR may underestimate kidney function in older adults, leading to a delayed diagnosis of kidney disease.

The role of cystatin C

Cystatin C is a protein produced by all nucleated cells in the body. Unlike creatinine, cystatin C is not influenced by muscle mass, making it a potentially more accurate marker of kidney function in older adults. Studies have shown that measuring eGFR based on cystatin C levels can better predict kidney disease progression and mortality risk in this population.

Advantages of measuring eGFR based on cystatin C levels

Measuring eGFR based on cystatin C levels offers several advantages in older adults:

• Accuracy: Cystatin C is less affected by factors such as age, sex, and muscle mass, providing a more accurate assessment of kidney function.
• Early detection: By using cystatin C, kidney disease can be detected earlier, allowing for timely intervention and management.
• Prediction of outcomes: Studies have shown that eGFR based on cystatin C levels can better predict the risk of kidney disease progression and mortality in older adults.

Conclusion

Measuring eGFR based on cystatin C levels may be a more accurate assessment of kidney function in older adults. By overcoming the limitations of eGFR, this approach enables early detection of kidney disease and better prediction of outcomes. Healthcare professionals should consider incorporating cystatin C measurements into their routine assessments of kidney function in older adults to provide optimal care.