Despite the consistent relationship between serum gamma-glutamyltransferase (GGT) and type 2 diabetes (T2D), one unsolved issue is the role of serum GGT in the well-known association between obesity and T2D. This study was performed to investigate whether the association between body mass index (BMI) and impaired fasting glucose (IFG) differed depending on serum GGT levels within the normal range.
Methods:
Study subjects were 2,424 men and 3,652 women aged = 40, participating in the Fifth Korean National Health and Nutrition Examination Survey.
Serum GGT levels within the normal range were classified into gender-specific tertiles.
Results:
Among men and women belonging to the lowest tertile of serum GGT, BMI showed statistically non-significant weak associations with the risk of IFG. However, among persons in the highest tertile of serum GGT, the risk of IFG was 3 – 4 times higher among persons with BMI = 25 kg/m2 than those with BMI
Conclusions:
The well-known strong association between BMI and IFG was observed mainly among persons with elevation of serum GGT to certain physiological levels, suggesting a critical role of serum GGT in the pathogenesis of IFG.
This finding has an important clinical implication because serum GGT can be used to detect high-risk obese persons.
Author: Nam Soo HongJeong-Gook KimYu-Mi LeeHyun-Woo KimSin KamKeon-Yeop KimKi-Su KimDuk-Hee Lee
Credits/Source: BMC Endocrine Disorders 2014, 14:57
Published on: 2014-07-12
Tweet
News Provider: 7thSpace Interactive / EUPB Press Office
Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
There are no comments available. Be the first to write a comment.