HEALTH DAILY NEWS

Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds to an antiviral drug, abacavir, it can lead to the formation of defective proteins, which trigger a stress response in the endoplasmic reticulum, ultimately cascading into drug eruption. This implies that HLA is involved in previously unknown signaling pathways and processes that go beyond its traditionally accepted role within the immune system. Credit: Shigeki Aoki from Chiba University Although medications Read More