PD-1 is required for neonatal heart regeneration. Credit: Nature Cardiovascular Research (2024). DOI: 10.1038/s44161-024-00447-7 When the heart is injured, as in a myocardial infarction, the damaged heart muscle cannot regenerate—instead, scar tissue forms. Cardiomyocytes, the heart muscle cells that generate contractile force, are lost for good. Yet, in mouse models, the hearts of newborns regenerate readily after injury. How are newborn hearts able to recover? What are the necessary ingredients for regeneration? Miao Cui, Ph.D., began asking these questions as a postdoctoral fellow in the lab of Eric Olson at Read More
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