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Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again – a curious phenomenon in science – says research by the University of Warwick.<\/p>\n
Professor Steven P. Brown from the Department of Physics, with colleagues in the Department of Chemistry, have identified that the supramolecular structure of a guanosine derivative can be different upon passing from the solid state into the solution state and vice versa. <\/p>\n
This defies chemical precedent, as self-assembled structures driven by the formation of specific intermolecular hydrogen bonds in solution would be expected to remain the same in the solid state.<\/p>\n
The phenomenon was revealed by the state-of-the-art nuclear magnetic resonance (NMR) facility at Warwick.<\/p>\n
In solution state, the guanosine derivative analysed by the researchers is constituted by quartet-like molecular structure – and scientific intuition would suggests that this should remain like this in the solid state.<\/p>\n
However, upon changing into the solid state, the supramolecular assembly surprisingly contains both quartet and ribbon structures.<\/p>\n
Professor Brown and his colleagues made this discovery using advanced NMR spectroscopy technology, which measures the magnetic response of nuclei at the centre of atoms. <\/p>\n
The researchers identified the distinct supramolecular states by spotting varying peaks in spectra that identify close approach of these magnetic nuclei in atoms.<\/p>\n
Professor Brown comments:<\/p>\n
“Access to state-of-the-art NMR infrastructure has enabled us to see with chemical precision how the guanosine-based molecules self-assemble, thus revealing the surprising phenomenon of a change in self-assembly upon going changing from solution to solid and from solid to solution.”<\/p>\n
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The University of Warwick’s national solid-state NMR facility is directed by Professor Brown and a Facility Executive with scientists from 4 other UK universities – and was officially launched in 2010. The facility and this research is funded by the Engineering and Physical Sciences Research Council.<\/p>\n
The research, ‘Co-existence of Distinct Supramolecular Assemblies in Solution and in the Solid State’, is published in Chemistry: A European Journal<\/em> – and is designated a Very Important Paper.<\/p>\n Professor Brown collaborated with researchers in Italy and the U.S.A.\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":" Cutting edge tech shows molecule self-assembling into different forms passing from solution state to solid state and back again – a curious phenomenon in science – says University of Warwick research Phenomenon discovered using state-of-the-art national solid-state NMR facility at Warwick Research published by Chemistry: A European Journal – designated as ‘Very Important Paper’ Cutting Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-155163","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/155163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=155163"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/155163\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=155163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=155163"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=155163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}