{"id":166272,"date":"2017-04-03T18:21:44","date_gmt":"2017-04-03T18:21:44","guid":{"rendered":"http:\/\/healthmedicinet.com\/i\/exercise-resistance-is-due-to-protein-secreted-in-liver\/"},"modified":"2017-04-03T18:21:44","modified_gmt":"2017-04-03T18:21:44","slug":"exercise-resistance-is-due-to-protein-secreted-in-liver","status":"publish","type":"post","link":"http:\/\/healthmedicinet.com\/i\/exercise-resistance-is-due-to-protein-secreted-in-liver\/","title":{"rendered":"&#8216;Exercise resistance&#8217; is due to protein secreted in liver"},"content":{"rendered":"<ul class=\"mol-bullets-with-font\">\n<li class=\"\"><strong>Exercise affects individuals differently and some derive little benefit<\/strong><\/li>\n<li class=\"\"><strong>It&#8217;s all down to a protein that&#8217;s secreted in the liver, say researchers<\/strong><\/li>\n<li class=\"\"><strong>Findings may lead to exercise-enhancing drugs, experts believe\u00a0<\/strong><\/li>\n<\/ul>\n<p class=\"author-section byline-plain\">By<\/p>\n<p>Claudia Tanner For Mailonline<\/a><\/p>\n<p class=\"byline-section\"><span class=\"article-timestamp article-timestamp-published\"><br \/>\n  <span class=\"article-timestamp-label\">Published:<\/span><br \/>\n  10:13 EDT, 3 April 2017<br \/>\n<\/span><br \/>\n | <span class=\"article-timestamp article-timestamp-updated\"><br \/>\n  <span class=\"article-timestamp-label\">Updated:<\/span><br \/>\n  10:44 EDT, 3 April 2017<br \/>\n<\/span>\n<\/p>\n<\/p>\n<ul>\n<li class=\"share-facebook\"><\/li>\n<li class=\"share-twitter\"><\/li>\n<li class=\"share-pinterest\"><\/li>\n<li class=\"share-gplus\">\n      <span class=\"g-interactivepost\"><br \/>\n        <a><\/a><br \/>\n      <\/span>\n        <\/li>\n<li class=\"share-email\">\n<p>                <span class=\"wai\">e-mail<\/span><br \/>\n            <\/a>\n        <\/li>\n<li class=\"share-icons\" id=\"shareLinkTop\">\n            <\/a>\n            <\/li>\n<\/ul>\n<p>     <span><\/span><\/p>\n<p class=\"count-number\">          31<\/p>\n<p class=\"count-text\">View <br \/> comments<\/p>\n<p>    <\/a><\/p>\n<p class=\"mol-para-with-font\">Some people experience greater rewards from exercise than others.<\/p>\n<p class=\"mol-para-with-font\">New research may have shed light on why this is &#8211; a liver protein may be to blame for &#8216;exercise resistance&#8217;.<\/p>\n<p class=\"mol-para-with-font\">According to experts in Japan, &#8216;some people derive little benefit from the health-promoting effects of regular exercise&#8217;.<\/p>\n<p class=\"mol-para-with-font\">In a study involving both mice and humans, higher levels of selenoprotein P &#8211; a protein secreted by the liver &#8211; was found to be linked with reduced exercise capacity and fewer exercise-related benefits.<\/p>\n<p>    <img loading=\"lazy\" decoding=\"async\" id=\"i-7f5e991cf337e192\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" height=\"461\" width=\"634\" alt=\"New research suggests that a liver protein may be to blame for exercise resistance\" class=\"blkBorder img-share\" \/><\/p>\n<p>    <img loading=\"lazy\" decoding=\"async\" id=\"i-7f5e991cf337e192\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/04\/03\/11\/3EE54B2B00000578-4375368-image-a-1_1491217106739.jpg\" height=\"461\" width=\"634\" alt=\"New research suggests that a liver protein may be to blame for exercise resistance\" class=\"blkBorder img-share\" \/><\/p>\n<p class=\"imageCaption\">New research suggests that a liver protein may be to blame for exercise resistance<\/p>\n<p class=\"mol-para-with-font\">The findings, from Kanazawa University, could mean selenoprotein P may be a driver of low responsiveness to exercise, or &#8216;exercise resistance&#8217; as the scientists label it.\u00a0<\/p>\n<p class=\"mol-para-with-font\">To test their theory, the researchers carried out two studies. The first was on a group of mice who were subjected to 30 minute treadmill runs for one month.<\/p>\n<p class=\"mol-para-with-font\">At the end of the month, the selenoprotein P-deficient mice showed higher exercise capacity than regular lab mice.<\/p>\n<p class=\"mol-para-with-font\">Additionally, the researchers found that mice lacking LRP1 &#8211; a selenoprotein P receptor in muscles &#8211; were unable to absorb selenoprotein P into their muscles.\u00a0<\/p>\n<p class=\"mol-para-with-font\">The second study involved 31 healthy but sedentary women who underwent aerobic training for eight weeks.\u00a0<\/p>\n<ul class=\"rotator-panels link-bogr1 linkro-ccox\">\n<li>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/04\/03\/09\/3EE425AE00000578-0-image-m-17_1491207569140.jpg\" width=\"62\" height=\"60\" \/><span>The bikini selfies that saved a life: Woman, 21, discovers&#8230;<\/span><br \/>\n        <\/a><\/p>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/04\/03\/10\/3EE4AE4600000578-0-image-m-33_1491210567675.jpg\" width=\"62\" height=\"60\" \/><span>Middle-aged men are turning to steroids to boost their&#8230;<\/span><br \/>\n        <\/a><\/p>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/04\/03\/01\/3EE1991100000578-0-image-a-92_1491178944540.jpg\" width=\"62\" height=\"60\" \/><span>Munch those worries away and stop the menopause stressing&#8230;<\/span><br \/>\n        <\/a><\/p>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/04\/03\/02\/3CC59E7400000578-0-image-m-128_1491181316988.jpg\" width=\"62\" height=\"60\" \/><span>British children are the biggest cry babies in the world:&#8230;<\/span><br \/>\n        <\/a>\n      <\/li>\n<\/ul>\n<p class=\"mol-para-with-font\">Scientists measured their maximal oxygen consumption and found that those who had high level of selenoprotein P in the blood before training did not show much elevation.<\/p>\n<p class=\"mol-para-with-font\">When maximal oxygen consumption is elevated, the body can take in more oxygen and deliver it to the muscles, enabling faster running.\u00a0<\/p>\n<p class=\"mol-para-with-font\">The research could shed light on diseases resulting from a sedentary lifestyle such as obesity and type-2 diabetes.<\/p>\n<p>    <img loading=\"lazy\" decoding=\"async\" id=\"i-d77f61f23da38bd8\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" height=\"203\" width=\"306\" alt=\"NHS guidelines say adults aged 19-64 should do at least 150 minutes of moderate aerobic activity such as cycling or fast walking every week, and strength exercises on two or more days a week\u00a0\" class=\"blkBorder img-share\" \/><\/p>\n<p>    <img loading=\"lazy\" decoding=\"async\" id=\"i-d77f61f23da38bd8\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/04\/03\/12\/3EE5554E00000578-4375368-image-a-5_1491218228767.jpg\" height=\"203\" width=\"306\" alt=\"NHS guidelines say adults aged 19-64 should do at least 150 minutes of moderate aerobic activity such as cycling or fast walking every week, and strength exercises on two or more days a week\u00a0\" class=\"blkBorder img-share\" \/><\/p>\n<p class=\"imageCaption\">NHS guidelines say adults aged 19-64 should do at least 150 minutes of moderate aerobic activity such as cycling or fast walking every week, and strength exercises on two or more days a week\u00a0<\/p>\n<p class=\"mol-para-with-font\">The study&#8217;s authors note: &#8216;In particular, some people show complete non-responsiveness to exercise training in terms of aerobic improvement.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;Similarly, 15-20 percent of patients with type 2 diabetes show a poor hypoglycemic effect to regular exercise therapy.<\/p>\n<p class=\"mol-para-with-font\">&#8216;These findings indicate that some people suffer from exercise resistance and derive limited benefits from the health-promoting effects of physical exercise.&#8217;<\/p>\n<p class=\"mol-para-with-font\">\n<p class=\"mol-para-with-font\">\n<p class=\"mol-para-with-font\">The team believes that the research findings may pave the way for drugs that reduce selenoprotein P production to improve exercise endurance.<\/p>\n<p class=\"mol-para-with-font\">Study co-author Hirofumi Misu and colleagues write: &#8216;The current findings suggest that future screening for inhibitors of the [selenoprotein P]-LRP1 axis could identify exercise-enhancing drugs to treat physical-inactivity-associated diseases such as type 2 diabetes.&#8217;<\/p>\n<p class=\"mol-para-with-font\">The study was published in the journal Nature Medicine.<\/p>\n<p>            <!-- ad: http:\/\/mads.dailymail.co.uk\/v2\/us\/health\/none\/article\/other\/inread_player.html --><\/p>\n<h3 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Your details from Facebook will be used to provide you with tailored content, marketing and ads in line with our Privacy Policy<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Exercise affects individuals differently and some derive little benefit It&#8217;s all down to a protein that&#8217;s secreted in the liver, say researchers Findings may lead to exercise-enhancing drugs, experts believe\u00a0 By Claudia Tanner For Mailonline Published: 10:13 EDT, 3 April 2017 | Updated: 10:44 EDT, 3 April 2017 e-mail 31 View comments Some people experience <a class=\"read-more-link\" href=\"http:\/\/healthmedicinet.com\/i\/exercise-resistance-is-due-to-protein-secreted-in-liver\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-166272","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/166272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=166272"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/166272\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=166272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=166272"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=166272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}