Endometriosis — a condition caused by uterine tissue growing outside of the organ — affects 10% of reproductive-aged women, whom it causes chronic pain that is significant and debilitating. The standard first-line treatment for all women with endometriosis is hormonal, specifically progestin-based, therapy. <\/p>\n
Yet a team of researchers at Yale has shown that the effectiveness of progestin-therapy depends on whether a woman’s endometriotic lesions have the progesterone receptor (PR) present. This study appears online in the Journal of Clinical Endocrinology Metabolism<\/em>.<\/p>\n The researchers tested the endometriotic lesions of 52 women who had undergone surgical evaluation for endometriosis at Yale New Haven Hospital for their PR status. They found a significant association between PR status and responsiveness to progestin-therapy. Those whose endometriotic lesions were PR-positive responded much better to the progestin-therapy, while those whose lesions were PR-negative found little relief from progestin-therapy alone. <\/p>\n From these findings, the research team concluded that knowing a woman’s PR-status may help them develop a “novel, targeted, precision-based” approach to treating and managing endometriosis individually. “Receptor status in endometriosis could be used in a manner analogous to the use of estrogen\/progesterone receptor status in breast cancer for tailoring hormonal-based regimens,” said Dr. Valerie Flores, first author and clinical instructor at the Yale School of Medicine. <\/p>\n “Such an approach to endometriosis management would make trialing progestin-based therapy to determine response unnecessary,” said Flores, “and would therefore minimize delays in providing the optimal medical therapy for each individual patient.” <\/p>\n ###<\/p>\n This study was funded by a grant from the National Institutes of Health. Other authors on this study include Arne Vanhie, Tran Dang, and Hugh Taylor.\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":" Endometriosis — a condition caused by uterine tissue growing outside of the organ — affects 10% of reproductive-aged women, whom it causes chronic pain that is significant and debilitating. The standard first-line treatment for all women with endometriosis is hormonal, specifically progestin-based, therapy. Yet a team of researchers at Yale has shown that the effectiveness Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-229526","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/229526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=229526"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/229526\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=229526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=229526"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=229526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}