{"id":235097,"date":"2019-01-29T10:11:47","date_gmt":"2019-01-29T10:11:47","guid":{"rendered":"http:\/\/healthmedicinet.com\/i\/tiny-rake-to-repair-crumbly-old-knees-by-collecting-stem-cells-from-the-joint\/"},"modified":"2019-01-29T10:11:47","modified_gmt":"2019-01-29T10:11:47","slug":"tiny-rake-to-repair-crumbly-old-knees-by-collecting-stem-cells-from-the-joint","status":"publish","type":"post","link":"http:\/\/healthmedicinet.com\/i\/tiny-rake-to-repair-crumbly-old-knees-by-collecting-stem-cells-from-the-joint\/","title":{"rendered":"Tiny rake to repair crumbly old knees by collecting stem cells from the joint"},"content":{"rendered":"<h2>Tiny rake to repair crumbly old knees by collecting stem cells from the joint<\/h2>\n<p class=\"author-section byline-plain\">By<\/p>\n<p>Roger Dobson for the Daily Mail<\/a><\/p>\n<p class=\"byline-section\"><span class=\"article-timestamp article-timestamp-published\"><br \/>\n  <span class=\"article-timestamp-label\">Published:<\/span><br \/>\n  18:18 EST, 28 January 2019<br \/>\n<\/span><br \/>\n | <span class=\"article-timestamp article-timestamp-updated\"><br \/>\n  <span class=\"article-timestamp-label\">Updated:<\/span><br \/>\n  18:20 EST, 28 January 2019<br \/>\n<\/span>\n<\/p>\n<\/p>\n<p><!-- ad: https:\/\/mads.dailymail.co.uk\/v4\/us\/health\/none\/article\/other\/para_top.html --><\/p>\n<p>    <img loading=\"lazy\" decoding=\"async\" id=\"i-5d60924534fbe523\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2019\/01\/28\/23\/9106152-6642205-image-a-22_1548717326558.jpg\" height=\"408\" width=\"306\" alt=\"Joint care: A rake-like device that sweeps up cells could give new life to arthritic knees\" class=\"blkBorder img-share\" \/><\/p>\n<p>    <img loading=\"lazy\" decoding=\"async\" id=\"i-5d60924534fbe523\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2019\/01\/28\/23\/9106152-6642205-image-a-22_1548717326558.jpg\" height=\"408\" width=\"306\" alt=\"Joint care: A rake-like device that sweeps up cells could give new life to arthritic knees\" class=\"blkBorder img-share\" \/><\/p>\n<p class=\"imageCaption\">Joint care: A rake-like device that sweeps up cells could give new life to arthritic knees<\/p>\n<p class=\"mol-para-with-font\">A rake-like device that sweeps up cells could give new life to arthritic knees.\u00a0<\/p>\n<p class=\"mol-para-with-font\">It collects stem cells \u2014 which can form new tissue \u2014 from the joint lining, then brushes them into blood clots to help the knee heal itself.<\/p>\n<p class=\"mol-para-with-font\">New research from the University of Leeds shows the treatment increases the number of repair cells in the area by a hundredfold.\u00a0<\/p>\n<p class=\"mol-para-with-font\">It also found that a conventional procedure for knee damage, called arthroscopy \u2014 a keyhole procedure to examine and clear out any damage \u2014 may actually clear out the cells it needs for repair.<\/p>\n<p class=\"mol-para-with-font\">\u2018These joint procedures are inadvertently washing out the resident stem cells,\u2019 explains Dennis McGonagle, a professor of investigative rheumatology at the university, who has led development of the new treatment. \u2018They may be sluicing away the very cells that are capable of repairing knees.\u2019<\/p>\n<p class=\"mol-para-with-font\">In a healthy joint, cartilage provides a low-friction surface to allow smooth joint movement. But wear and tear and knocks take their toll, and cartilage can become damaged, leaving bone rubbing on bone, causing the pain and loss of movement associated with osteoarthritis.<\/p>\n<ul class=\"rotator-panels link-bogr1 linkro-ccox\">\n<li>\n<p>  <span>Woman who went to hospital with agonising abdominal pain and&#8230;<\/span><\/p>\n<p><\/a><\/p>\n<p>  <span>Don&#8217;t call us heroes: Cancer patients do not like being&#8230;<\/span><\/p>\n<p><\/a><\/p>\n<p>  <span>Crohn&#8217;s disease sufferer goes from 4st to 8st in just three&#8230;<\/span><\/p>\n<p><\/a><\/p>\n<p>  <span>Doctors remove poisonous CATFISH from man&#8217;s throat after he&#8230;<\/span><\/p>\n<p><\/a><\/p>\n<\/li>\n<\/ul>\n<p class=\"mol-para-with-font\">In severe cases, a total knee replacement is needed, but in more common mild to moderate cases, a range of other approaches are used, including painkillers, knee braces and arthroscopic procedures.<\/p>\n<p class=\"mol-para-with-font\">One technique, microfracture, involves using a drill or pick to make small holes in the bone surfaces inside the joint to encourage new cartilage to grow. The stem cells that are released are thought to be trapped in blood clots, contributing to the repair of the cartilage.<\/p>\n<p class=\"mol-para-with-font\">But one of the problems is that it had been thought the number of repair stem cells in the knee is low. The Leeds team discovered that the synovial fluid, an egg white-like lubricant within joints, contains stem cells.<\/p>\n<h3 class=\"mol-factbox-title\">DID YOU KNOW?\u00a0<\/h3>\n<p class=\"mol-para-with-font\">Blood jabs can reduce the pain of knee arthritis \u2014 and the effect lasted longer than steroid injections, a common treatment, reports the journal Orthopade.<\/p>\n<p class=\"mol-para-with-font\">Around 120 patients were given injections of platelet-rich plasma (PRP), steroids or hyaluronic acid, a joint lubricant, in their knees.\u00a0<\/p>\n<p class=\"mol-para-with-font\">PRP is derived from the patient\u2019s blood, which is treated so it has much higher concentrations of platelets, which contain growth factors important for healing.\u00a0<\/p>\n<p class=\"mol-para-with-font\">All helped, but the research by Jinan University, China, showed that PRP was effective for longer.<\/p>\n<p class=\"mol-para-with-font\">Further research also showed that this fluid stopped stem cells sticking to injured cartilage and also that surgical procedures inadvertently wash away these cells. A device was then developed to release lots more stem cells from the joint lining.<\/p>\n<p class=\"mol-para-with-font\">Following lab tests this is now being tested on patients with knee arthritis. The new procedure on trial involves creating a microfracture, which results in a clot \u2014 and then stem cells are collected by raking them into the clot with the specially designed device inserted through a small hole made in the joint.<\/p>\n<p class=\"mol-para-with-font\">In a recent report in The American Journal of Sports Medicine, the Leeds researchers found that the brush resulted in a 105-fold increase in the number of stem cells.<\/p>\n<p class=\"mol-para-with-font\">Professor McGonagle says: \u2018We believe the new approach will greatly increase the reparative capacity of the joint by boosting stem cell numbers and keeping them within the joint after surgery.\u2019<\/p>\n<p class=\"mol-para-with-font\">The new trial will involve 20 patients undergoing microfracture \u2014 half will also have the stem cell treatment.<\/p>\n<p class=\"mol-para-with-font\">Roger Hackney, a consultant orthopaedic surgeon at the Spire and Nuffield hospitals in Leeds, says: \u2018Knowing whether increasing the numbers of stem cells available improves outcomes using a device such as this adds another piece of the jigsaw, but we are a long way off no longer needing surgery for osteoarthritis.\u2019<\/p>\n<p class=\"mol-para-with-font\">\u00a0<\/p>\n<p>            <!-- ad: https:\/\/mads.dailymail.co.uk\/v4\/us\/health\/none\/article\/other\/inread_player.html --><\/p>\n<p>        <\/a><\/p>\n<h3>Comments <span class=\"readerCommentsCount\">2<\/span><\/h3>\n<p>\n\t    Share what you think\n          <\/p>\n<ul id=\"rc-tabs\" class=\"js-links dm-tabs cnr5 cleared\">\n<li class=\"dm-tab dm-tab-on bdrgr5 cnr-bdr wogr5 link-wox js-active\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Newest<\/a>\n      <\/li>\n<li class=\"dm-tab bdrgr5 ow-igr2-bx cnr-bdr xogr2 link-gr5ox\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Oldest<\/a>\n      <\/li>\n<li class=\"dm-tab bdrgr5 ow-igr2-bx cnr-bdr xogr2 link-gr5ox\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Best rated<\/a>\n      <\/li>\n<li class=\"dm-tab bdrgr5 ow-igr2-bx cnr-bdr xogr2 link-gr5ox last\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Worst rated<\/a>\n      <\/li>\n<\/ul>\n<p>The comments below have not been moderated.<\/p>\n<p class=\"bold pad5 wogr5 rc-info\">\n      The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.\n    <\/p>\n<p>  <\/a><\/p>\n<p>      <a id=\"newcomment\" name=\"newcomment\"><\/a><\/p>\n<p>              <span>Close<\/span><\/a><\/p>\n<p class=\"modal-title\">Do you want to automatically post your MailOnline comments to your Facebook Timeline?<\/p>\n<p class=\"modal-subtitle\">Your comment will be posted to MailOnline as usual.<\/p>\n<p>\u00a0<\/p>\n<p>            <span>Close<\/span><\/a><\/p>\n<p class=\"modal-title\">Do you want to automatically post your MailOnline comments to your Facebook Timeline?<\/p>\n<p class=\"modal-subtitle\">Your comment will be posted to MailOnline as usual<\/p>\n<p>  We will automatically post your comment and a link to the news story to your Facebook timeline at the same time it is posted on MailOnline. 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Your details from Facebook will be used to provide you with tailored content, marketing and ads in line with our Privacy Policy<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tiny rake to repair crumbly old knees by collecting stem cells from the joint By Roger Dobson for the Daily Mail Published: 18:18 EST, 28 January 2019 | Updated: 18:20 EST, 28 January 2019 Joint care: A rake-like device that sweeps up cells could give new life to arthritic knees A rake-like device that sweeps <a class=\"read-more-link\" href=\"http:\/\/healthmedicinet.com\/i\/tiny-rake-to-repair-crumbly-old-knees-by-collecting-stem-cells-from-the-joint\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-235097","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/235097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=235097"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/235097\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=235097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=235097"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=235097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}