{"id":304749,"date":"2024-05-16T22:48:10","date_gmt":"2024-05-16T22:48:10","guid":{"rendered":"https:\/\/healthmedicinet.com\/i\/study-shows-vicious-cycle-of-protein-clumping-in-alzheimers-disease-and-normal-aging\/"},"modified":"2024-05-16T22:48:10","modified_gmt":"2024-05-16T22:48:10","slug":"study-shows-vicious-cycle-of-protein-clumping-in-alzheimers-disease-and-normal-aging","status":"publish","type":"post","link":"http:\/\/healthmedicinet.com\/i\/study-shows-vicious-cycle-of-protein-clumping-in-alzheimers-disease-and-normal-aging\/","title":{"rendered":"Study shows vicious cycle of protein clumping in Alzheimer\u2019s disease and normal aging"},"content":{"rendered":"<p>Amyloid ? accelerates age-related proteome-wide protein insolubility. Credit: GeroScience (2024). DOI: 10.1007\/s11357-024-01169-1 It has long been known that a hallmark of Alzheimer&#8217;s disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain. During normal disease-free aging, there is also an accumulation of insoluble proteins. To date, approaches to treatments for Alzheimer&#8217;s disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Buck researchers have recently completed a systematic study in worms that <a class=\"read-more-link\" href=\"https:\/\/healthmedicinet.com\/study-shows-vicious-cycle-of-protein-clumping-in-alzheimers-disease-and-normal-aging\/\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amyloid ? accelerates age-related proteome-wide protein insolubility. Credit: GeroScience (2024). DOI: 10.1007\/s11357-024-01169-1 It has long been known that a hallmark of Alzheimer&#8217;s disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain. During normal disease-free aging, there is also an accumulation of insoluble proteins. To date, approaches to <a class=\"read-more-link\" href=\"http:\/\/healthmedicinet.com\/i\/study-shows-vicious-cycle-of-protein-clumping-in-alzheimers-disease-and-normal-aging\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-304749","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/304749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=304749"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/304749\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=304749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=304749"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=304749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}