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Tissue of boy, 5, who died of tumor leads to breakthrough

 

Chad Carr, the grandson of legendary college football coach Lloyd Carr, was just five years old when he died. 

The precocious little boy from Michigan contracted diffuse intrinsic pontine glioma (DIPG), a lethal and untreatable brain tumor which predominantly affects children under the age of nine.

The cruel disease is incredibly difficult to detect; most sufferers are diagnosed just months before they die. 

Chad’s family had just 14 months with him after his diagnosis. 

But now, a year-and-a-half after passing away, scientists are honoring his memory with a research paper, showing an analysis of his brain has led to a major breakthrough in understanding the genetic mutations that drive DIPG.

Experts say the unprecedented finding is the first concrete result of any study into the little-understood disease.  

‘This was Chad’s final physical gift and to see that gift making a difference to DIPG research that will someday change the future for other children means so much to us,’ says Chad’s mom Tammi Carr. 

Chad Carr (pictured) died in 2015 aged five, 14 months after he was diagnosed with DIPG

Chad Carr (pictured) died in 2015 aged five, 14 months after he was diagnosed with DIPG

Chad Carr (pictured) died in 2015 aged five, 14 months after he was diagnosed with DIPG

Chad's mom Tammi Carr (pictured) said his tissue donation was his final gift to the world

Chad's mom Tammi Carr (pictured) said his tissue donation was his final gift to the world

Chad’s mom Tammi Carr (pictured) said his tissue donation was his final gift to the world

WHAT IS DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)? 

A Diffuse intrinsic pontine glioma (DIPG) is a rare an inoperable type of brain tumor. 

It mostly affects children, with most diagnoses occurring between four and 11 years of age. 

More than 90 percent of its victims will die within 18 months of diagnosis. 

Each year, there are around 100-150 new diagnoses in the United States. 

The cause of the tumor remains unknown. 

Symptoms include lack of facial control, double vision, headaches, vomiting, weakness, seizures and balance problems. 

One of the early indicators of the cancer is a child falling, tripping or losing balance.

‘Typically, with a biopsy, we get a single snapshot of the genetic characteristics of the tumor. That doesn’t always give you an accurate picture because each region of the tumor may be driven by different genetic changes,’ says lead author Carl Koshmann, M.D., a pediatric oncologist at U-M’s C.S. Mott Children’s Hospital.

‘In this case, we were able to sequence and analyze samples from one time point from six different regions of the tumor – which gives us an incredibly rich resource of what we can learn from one DIPG. This goes much further in telling the genetic life story of the tumor.’

The research, supported by Michigan Medicine’s Pediatric Brain Tumor Research Initiative, establishes that a mutation in a gene known as PTEN – not previously seen as a major DIPG driver – plays an early and important role in DIPG’s fatal course. The project was a result of the collaboration of DIPG research among pediatrics, neurosurgery and pathology at Michigan Medicine. 

In a normal cell, the PTEN gene plays an integral role in suppressing cancer, killing off cells that aren’t behaving the way they’re supposed to. Any loss or mutation of the gene makes the tumor more effective.

But PTEN has not historically been considered a key driver of DIPG in children, and it remains unclear how early or ‘clonal’ it is in the development of these tumors. 

Mutations that are seen throughout multiple regions in a tumor are considered to be crucial events in the earliest clusters, or clones, of cancer cells. 

These clonal events lead to widespread changes in the tumor that may provide ideal targets for precision medicine therapies.

Koschmann says the new data adds to multiple pieces of compelling evidence suggesting that PTEN should be considered in treatment decisions. Researchers also analyzed data from the PedcBioPortal – a national dataset of pediatric cancer genomics data – and found alterations in PTEN in up to 5 percent of DIPG cases.

This is frequent enough to show it’s a recurring mutation, Koschmann says.

‘PTEN has not historically been considered one of the major four mutations of DIPG. However, we found a mutation in both copies of PTEN in every single region of Chad’s tumor, which was unexpected. These findings have unearthed the gene mutation’s key and early role in DIPG development,’ says Koschmann.

‘This study strengthens the case that alterations of the PTEN gene play a more influential role than was previously understood and should be included in future sequencing panels for pediatric DIPG,’ he adds. ‘If we find it, it’s something we can hopefully target with precision therapy.’

While some gene mutations don’t yet have a drug that targets them, PTEN has been targeted in breast and prostate cancer, Koschmann says, which is why it may benefit future DIPG patients.

Sequencing Chad’s 4.6-centimeter tumor in multiple regions allowed researchers to clarify how the DIPG behaved in each location of the brain and brain stem. It’s an example of how this type of data can help create an ‘evolutionary map’ of the tumor, Koschmann says.

‘We are able to look at what DIPG looks like after it’s been through traditional therapy and learning how the tumor grew and evaded those treatments,’ Koschmann says. ‘Studying tumor tissue in this way is like reading a textbook on how the tumor evolved after treatments and how we may potentially cut that off in the future.’

Diffuse intrinsic pontine glioma (DIPG), a lethal and untreatable brain tumor which predominantly affects children under the age of nine. The cruel disease is incredibly difficult to detect; most sufferers are diagnosed months before they die (pictured: Chad and his family)

Diffuse intrinsic pontine glioma (DIPG), a lethal and untreatable brain tumor which predominantly affects children under the age of nine. The cruel disease is incredibly difficult to detect; most sufferers are diagnosed months before they die (pictured: Chad and his family)

Diffuse intrinsic pontine glioma (DIPG), a lethal and untreatable brain tumor which predominantly affects children under the age of nine. The cruel disease is incredibly difficult to detect; most sufferers are diagnosed months before they die (pictured: Chad and his family)

Michigan researchers say since the Carr story gained national attention, more families have also asked for biopsies or autopsies of tumors

Michigan researchers say since the Carr story gained national attention, more families have also asked for biopsies or autopsies of tumors

Michigan researchers say since the Carr story gained national attention, more families have also asked for biopsies or autopsies of tumors

Tumor tissue donations in pediatric cancer cases have historically been rare because they need to happen just hours after death. Doctors are not likely to even broach the topic with families. Michigan researchers say since the Carr story gained national attention, more families have also asked for biopsies or autopsies of tumors.

Chad’s story galvanized the community, inspiring the #ChadTough movement and U-M Chad Tough Fund. This study is the first of several expected to be published as the momentum for DIPG research builds.

It’s all part of Chad’s legacy, Tammi Carr says.

‘We knew from early on in Chad’s journey that we would do whatever we could to create change, and we knew Chad would be a part of that change,’ she says.

‘To now see all of the work that has been done in DIPG research and the discoveries that have been made, we are seeing Chad’s gift having an incredible impact.’

Brain tumors are the leading cause of death from childhood cancer. The most devastating type is DIPG, which stems from the region of the brain that controls breathing and heart rate. More than 90 percent of children diagnosed with DIPG die within 18 months.

‘The current prognosis for DIPG remains bleak despite hundreds of previous clinical trials,’ Koschmann says. ‘A deeper molecular understanding of each individual tumor is needed to guide therapeutic decisions.

‘As we see more funding and more interest in DIPG research, we are learning more each day. The new genetic information we gain from studies like this will help us get closer to developing a new approach to treating children with what is now an incurable disease.’

 

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