{"id":263964,"date":"2020-11-03T05:02:05","date_gmt":"2020-11-03T05:02:05","guid":{"rendered":"http:\/\/healthmedicinet.com\/i2\/covid-19-nanoparticle-vaccine-could-trigger-strong-immune-response\/"},"modified":"2020-11-03T05:02:05","modified_gmt":"2020-11-03T05:02:05","slug":"covid-19-nanoparticle-vaccine-could-trigger-strong-immune-response","status":"publish","type":"post","link":"http:\/\/healthmedicinet.com\/i2\/covid-19-nanoparticle-vaccine-could-trigger-strong-immune-response\/","title":{"rendered":"COVID-19 &#8216;nanoparticle&#8217; vaccine could trigger strong immune response"},"content":{"rendered":"<h2>Scientists develop a &#8216;nanoparticle&#8217; COVID-19 vaccine that could trigger a 10-times stronger immune response than the reaction seen in survivors and protect against future mutated strains<\/h2>\n<ul class=\"mol-bullets-with-font\">\n<li class=\"class\"><strong>Scientists have developed an experimental vaccine that uses nanoparticles, which mimic the structural features of the coronavirus<\/strong><\/li>\n<li class=\"class\"><b>The body is trained to recognize\u00a0the receptors the virus uses to enter and infect human cells, and builds up antibodies<\/b><\/li>\n<li class=\"class\"><b>In mice, the virus produced ten times more neutralizing antibodies than those seen in COVID-19 survivors<\/b><\/li>\n<li class=\"class\"><b>The jab also produced a strong memory cell response, in which the body remembers the invading virus to produce antibodies if infected in the future<\/b><\/li>\n<li class=\"class\"><b>In one monkey, the vaccine bound to different parts of the vaccine&#8217;s spike protein, which could protect against future mutated strains<\/b><\/li>\n<\/ul>\n<p class=\"author-section byline-plain\">By Mary Kekatos Senior Health Reporter For Dailymail.com<\/a> <\/p>\n<p class=\"byline-section\"><span class=\"article-timestamp article-timestamp-published\"> <span class=\"article-timestamp-label\">Published:<\/span>  17:06 EST, 2 November 2020 <\/span> | <span class=\"article-timestamp article-timestamp-updated\"> <span class=\"article-timestamp-label\">Updated:<\/span>  22:40 EST, 2 November 2020 <\/span> <\/p>\n<\/p>\n<p> <!-- ad: https:\/\/mads.dailymail.co.uk\/v6\/us\/health\/none\/article\/other\/para_top.html --> <\/p>\n<p class=\"mol-para-with-font\">Scientists say they have developed an experimental coronavirus<\/a> vaccine candidate that is far more potent than others currently being investigated.<\/p>\n<p class=\"mol-para-with-font\">In trials conducted in mice, the team from the University of Washington School of Medicine said its vaccine<\/a> triggered a 10-times stronger immune response to the infection than seen in COVID-19 survivors.<\/p>\n<p class=\"mol-para-with-font\">What&#8217;s more, it also provoked a strong memory cell response, in which the body remembers the invading virus to produce antibodies more quickly if infected.<\/p>\n<p class=\"mol-para-with-font\">The team says its vaccine does not require freezer storage like those being made by other companies, which makes it easier to produce and ship across the globe.<\/p>\n<p>   <img loading=\"lazy\" decoding=\"async\" id=\"i-b0f9fc7934388273\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165300-8906965-image-a-57_1604352551497.jpg\" height=\"410\" width=\"634\" alt=\"v\" class=\"blkBorder img-share\" \/>  <img loading=\"lazy\" decoding=\"async\" id=\"i-b0f9fc7934388273\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165300-8906965-image-a-57_1604352551497.jpg\" height=\"410\" width=\"634\" alt=\"v\" class=\"blkBorder img-share\" \/>  <\/p>\n<p class=\"imageCaption\">\n<\/p>\n<p>   <img loading=\"lazy\" decoding=\"async\" id=\"i-6c8ef7e7e58c47e7\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165298-8906965-image-a-58_1604353173566.jpg\" height=\"425\" width=\"634\" alt=\"The jab also produced a strong memory cell response, in which the body remembers the invading virus to produce antibodies more quickly in a future infection. Pictured: An artist's depiction of the\u00a0 vaccine candidate in which 60 pieces of a coronavirus protein (red) decorate nanoparticles (blue and white) to get the body to recognize the receptors\" class=\"blkBorder img-share\" \/>  <img loading=\"lazy\" decoding=\"async\" id=\"i-6c8ef7e7e58c47e7\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165298-8906965-image-a-58_1604353173566.jpg\" height=\"425\" width=\"634\" alt=\"The jab also produced a strong memory cell response, in which the body remembers the invading virus to produce antibodies more quickly in a future infection. Pictured: An artist's depiction of the\u00a0 vaccine candidate in which 60 pieces of a coronavirus protein (red) decorate nanoparticles (blue and white) to get the body to recognize the receptors\" class=\"blkBorder img-share\" \/>  <\/p>\n<p class=\"imageCaption\">The jab also produced a strong memory cell response, in which the body remembers the invading virus to produce antibodies more quickly in a future infection. Pictured: An artist&#8217;s depiction of the\u00a0 vaccine candidate in which 60 pieces of a coronavirus protein (red) decorate nanoparticles (blue and white) to get the body to recognize the receptors<\/p>\n<p class=\"mol-para-with-font\">&#8216;We hope that our nanoparticle platform may help fight this pandemic that is causing so much damage to our world,&#8217; said Dr Neil King,\u00a0an assistant professor of biochemistry at the UW School of Medicine.\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;The potency, stability, and manufacturability of this vaccine candidate differentiate it from many others under investigation.&#8217;\u00a0<\/p>\n<p class=\"mol-para-with-font\">Nanoparticles, whether they are natural or synthetic, mimic the structural features of viruses, which are often nano-sized themselves.\u00a0<\/p>\n<p class=\"mol-para-with-font\">This makes it easier for the the nanoparticles to mold to the size and shape of the virus receptors.\u00a0<\/p>\n<p class=\"mol-para-with-font\">UW Medicine&#8217;s vaccine candidate\u00a0<span>displays 60 copies of the coronavirus&#8217;s receptor-binding domain, which the virus\u00a0<\/span>allows it to dock to body receptors to gain entry into cells.<\/p>\n<ul class=\"rotator-panels link-bogr1 linkro-ccox\">\n<li>  <span>People who catch a higher &#8216;dose&#8217; of coronavirus are more&#8230;<\/span> <\/a>  <span>Number of hospitalized COVID-19 patients in the US nears&#8230;<\/span> <\/a> <\/li>\n<\/ul>\n<p class=\"mol-para-with-font\"><span>The body will then be trained to recognize these receptors and build up antibodies against them to prevent a future infection from taking root.<\/span><\/p>\n<p class=\"mol-para-with-font\"><span>For the study, published in the journal Cell<\/a>, the team tested its new nanoparticle vaccine in mice.<\/span><\/p>\n<p class=\"mol-para-with-font\">Results showed that the jab produced ten times more neutralizing antibodies than those that develop naturally to the infections.<\/p>\n<p class=\"mol-para-with-font\">What&#8217;s more, this occurred even when the vaccine was administered at a five-fold lower dose.<\/p>\n<p class=\"mol-para-with-font\">Immunizations also resulted in a strong B cell response, which lock onto the surface of an invading pathogens and mark them for destruction by other immune cells.<\/p>\n<p>   <img loading=\"lazy\" decoding=\"async\" id=\"i-43ee1f14f6ea86fd\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165048-8906965-image-a-53_1604352277924.jpg\" height=\"433\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <img loading=\"lazy\" decoding=\"async\" id=\"i-43ee1f14f6ea86fd\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165048-8906965-image-a-53_1604352277924.jpg\" height=\"433\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <\/p>\n<p class=\"imageCaption\">\n<p>   <img loading=\"lazy\" decoding=\"async\" id=\"i-cd1d1a14a2f4ede1\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165046-8906965-image-a-54_1604352283663.jpg\" height=\"442\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <img loading=\"lazy\" decoding=\"async\" id=\"i-cd1d1a14a2f4ede1\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165046-8906965-image-a-54_1604352283663.jpg\" height=\"442\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <\/p>\n<p class=\"imageCaption\">\n<p>   <img loading=\"lazy\" decoding=\"async\" id=\"i-6576afcfdda099bc\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165252-8906965-image-a-55_1604352478958.jpg\" height=\"442\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <img loading=\"lazy\" decoding=\"async\" id=\"i-6576afcfdda099bc\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165252-8906965-image-a-55_1604352478958.jpg\" height=\"442\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <\/p>\n<p class=\"imageCaption\">\n<p class=\"mol-para-with-font\">They also form memory cells that remember the invading virus to produce antibodies faster in case of future infection, which is important in the search for a vaccine.<\/p>\n<p class=\"mol-para-with-font\">The inoculation was given to one\u00a0<span>nonhuman primate -a\u00a0 pigtail macaque &#8211; it produced neutralizing antibodies that targeted multiple different sites on the spike protein, which the virus uses to enter and infect cells.<\/span><\/p>\n<p class=\"mol-para-with-font\"><span>Researchers say this may help protect people from being infected by mutated strains of the virus.<\/span><\/p>\n<p class=\"mol-para-with-font\">The team adds that this vaccine does not need to be stored at freezing temperatures &#8211; such as those developed by Pfizer Inc and Moderna Inc &#8211; which could allow for much faster global vaccination.<\/p>\n<p class=\"mol-para-with-font\">However, future human studies are needed.\u00a0\u00a0\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">According to KIRO 7<\/a>, the vaccine is being licensed to two biotech companies to be mass-manufactured, and clinical trials are expected to begin by the end of the year.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;I am delighted that our studies of antibody responses to coronaviruses led to the design of this promising vaccine candidate,&#8217; said co-lead author Dr David Veesler, a UW associate professor of biochemistry.<\/p>\n<p>   <img loading=\"lazy\" decoding=\"async\" id=\"i-1c69a23c9020f219\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165696-8906965-image-a-59_1604353180010.jpg\" height=\"474\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <img loading=\"lazy\" decoding=\"async\" id=\"i-1c69a23c9020f219\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2020\/11\/02\/21\/35165696-8906965-image-a-59_1604353180010.jpg\" height=\"474\" width=\"634\" alt=\"\" class=\"blkBorder img-share\" \/>  <\/p>\n<p class=\"imageCaption\">\n<p>            <!-- ad: https:\/\/mads.dailymail.co.uk\/v6\/us\/health\/none\/article\/other\/inread_player.html --><\/p>\n<p>        <\/a><\/p>\n<h3>Comments <span class=\"readerCommentsCount\">393<\/span><\/h3>\n<p>\n\t    Share what you think\n          <\/p>\n<ul id=\"rc-tabs\" class=\"js-links dm-tabs cnr5 cleared\">\n<li class=\"dm-tab dm-tab-on bdrgr5 cnr-bdr wogr5 link-wox js-active\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Newest<\/a>\n      <\/li>\n<li class=\"dm-tab bdrgr5 ow-igr2-bx cnr-bdr xogr2 link-gr5ox\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Oldest<\/a>\n      <\/li>\n<li class=\"dm-tab bdrgr5 ow-igr2-bx cnr-bdr xogr2 link-gr5ox\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Best rated<\/a>\n      <\/li>\n<li class=\"dm-tab bdrgr5 ow-igr2-bx cnr-bdr xogr2 link-gr5ox last\">\n        <span class=\"xogr5 tl\"><\/span><br \/>\n        <span class=\"xogr5 tr\"><\/span><br \/>\n        Worst rated<\/a>\n      <\/li>\n<\/ul>\n<p>The comments below have not been moderated.<\/p>\n<p class=\"bold pad5 wogr5 rc-info\">\n      The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.\n    <\/p>\n<p>  <\/a><\/p>\n<p>      <a id=\"newcomment\" name=\"newcomment\"><\/a><\/p>\n<p>              <span>Close<\/span><\/a><\/p>\n<p class=\"modal-title\">Do you want to automatically post your MailOnline comments to your Facebook Timeline?<\/p>\n<p class=\"modal-subtitle\">Your comment will be posted to MailOnline as usual.<\/p>\n<p>\u00a0<\/p>\n<p>            <span>Close<\/span><\/a><\/p>\n<p class=\"modal-title\">Do you want to automatically post your MailOnline comments to your Facebook Timeline?<\/p>\n<p class=\"modal-subtitle\">Your comment will be posted to MailOnline as usual<\/p>\n<p>  We will automatically post your comment and a link to the news story to your Facebook timeline at the same time it is posted on MailOnline. 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Your details from Facebook will be used to provide you with tailored content, marketing and ads in line with our Privacy Policy<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists develop a &#8216;nanoparticle&#8217; COVID-19 vaccine that could trigger a 10-times stronger immune response than the reaction seen in survivors and protect against future mutated strains Scientists have developed an experimental vaccine that uses nanoparticles, which mimic the structural features of the coronavirus The body is trained to recognize\u00a0the receptors the virus uses to enter [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[310],"tags":[543],"class_list":["post-263964","post","type-post","status-publish","format-standard","hentry","category-health","tag-health"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/posts\/263964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/comments?post=263964"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/posts\/263964\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/media?parent=263964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/categories?post=263964"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/i2\/wp-json\/wp\/v2\/tags?post=263964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}