Graphical abstract. Credit: Journal of Allergy and Clinical Immunology (2023). DOI: 10.1016/j.jaci.2023.11.914 A collaborative research team has pioneered a new stem cell model to help personalize treatment for patients suffering from rare forms of immunodeficiency. The research findings were published in the Journal of Allergy and Clinical Immunology. Primary immunodeficiencies, also known as “inborn errors […]
An immune-compromised man with a year-and-a-half-long COVID infection served as a breeding ground for dozens of coronavirus mutations, a new study discovered. Worse, several of the mutations were in the COVID spike protein, indicating that the virus had attempted to evolve around current vaccines, researchers report. “This case underscores the risk of persistent SARS-CoV-2 infections […]
Description of the turning points for women study. Credit: Frontiers in Psychology (2024). DOI: 10.3389/fpsyg.2023.1321355 Adolescence is the prime time to help young women who’ve had repeated run-ins with the U.S. juvenile justice system find a different path, new University of Oregon research finds. The study, authored by faculty members in the UO’s College of […]
Using three-dimensional imaging technology, the Gladstone team examined blood-brain barrier leaks and distribution of the blood-clotting protein fibrin in a whole intact mouse brain after traumatic brain injury. Fibrin deposits appear in red. Credit: Gladstone institutes For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely. Not […]
C. Everett Koop, the avuncular doctor with a fluffy white beard who served as the U.S. surgeon general during the Reagan administration, was famous for his work as an innovative pediatric surgeon and the attention he paid to the HIV-AIDS crisis. As dentistry scholars, we believe Koop also deserves credit for something else. To help […]
Credit: Yaroslav Shuraev from Pexels Most of us are all too familiar with the consequences of a poor night’s sleep—be it interrupted sleep or simply too little of it. If you’re a parent with kids at home, it often leaves you and your children on edge. Children with neurodiverse conditions, such as autism and attention-deficit/hyperactivity […]
Cedars-Sinai investigators have identified significant variations in the microbes of the small bowel (small intestine) are strongly associated with various body weights, from a normal body mass index, or BMI, to having obesity. The gut microbiome includes the bacteria, fungi, and viruses that inhabit the human gastrointestinal tract. Imbalances in these microbial populations have previously […]
You may have heard of Ozempic, the “miracle drug” for weight loss, but did you know that it was actually designed as a new treatment to manage diabetes? In Canada, diabetes affects approximately 10% of the general population. Of those cases, 90% have type 2 diabetes. This metabolic disorder is characterized by persistent high blood […]
Credit: Pexels/RDNE stock project You’re not in your 20s or 30s anymore and you know regular health checks are important. So you go to your GP. During the appointment they measure your waist. They might also check your weight. Looking concerned, they recommend some lifestyle changes. GPs and health professionals commonly measure waist circumference as […]
Scores for the Brief Symptom Inventory domains of anxiety, hostility, interpersonal sensitivity, paranoid thoughts, and phobic anxiety, and Global Severity Index scores for the yoga and comparison groups before (pre-intervention) and after (post-intervention) 10 weeks of the TAY intervention Previous studies in correctional facilities have shown positive effects of yoga on inmates. They experience increased […]
The cellular and molecular alterations associated with ovarian aging revealed by spatiotemporal transcriptomics. Protein & Cell (2023). DOI: 10.1093/procel/pwad063 The ovary is an essential organ for female fertility, and its age-dependent decline in function is a major cause of infertility. However, the molecular mechanisms underlying ovarian aging are still not well understood, particularly in higher […]
Ethanol and its metabolites, epigenetic modifications, different types of metabolic alterations, immunosuppressive TME and oncogenic signaling pathwayscontribute to the development of A-HCC. Credit: Fu, Yaojie, Maccioni, Luca, Wang, Xin Wei, Greten, Tim F, Gao, Bin. While heavy drinking is a well-established risk factor for liver cancer, the specific mechanisms by which alcohol contributes to A-HCC […]
Optical coherence tomography. Credit: LaNCE-Neuropharm—GIC 21/133 Although there are still some aspects pending confirmation for its use in the clinical setting, and its resolution needs to be improved slightly, a study by the UPV/EHU and Biobizkaia has shown that a method routinely used to carry out ophthalmological tests can also be used to monitor the […]
Formalizing tasks for causal ML. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-02902-1 Artificial intelligence is making progress in the medical arena. When it comes to imaging techniques and the calculation of health risks, there is a plethora of AI methods in development and testing phases. Wherever it is a matter of recognizing patterns in large data […]
Credit: Darya Sannikova/Pexels Whether you’re watching TV, attending a footy game, or eating a meal at your local pub, gambling is hard to escape. Although the rise of gambling is not unique to Australia, it has become normalized as a part of Australian culture. While for some, gambling might be a source of entertainment, for […]
Unsafe sleep practices underlie most sudden unexpected infant deaths in the U.S., with three-quarters of infants affected by multiple unsafe practices at the time of death, and almost 60% sharing a sleep surface with another person. These are the key findings from our recent study published in Pediatrics. Sudden unexpected infant death, or SUID, occurs […]
Ebola virus outbreaks in the Democratic Republic of the Congo, 1976–2022. Credit: The Lancet Microbe (2024). DOI: 10.1016/S2666-5247(23)00259-8 Epidemiology researchers are harnessing tools developed by the Johns Hopkins Applied Physics Laboratory (APL) in Laurel, Maryland, to untangle the origins of the 2020 Ebola virus disease outbreak in the Democratic Republic of Congo (DRC). An article […]
In silico studies of c.920C>A;p.(Thr307Lys) variant in the RPGR gene. Credit: Cells (2024). DOI: 10.3390/cells13060524 Ciliopathies are rare diseases in which the formation or function of cilia, cylindrical-shaped extensions found on the surface of many cells, is altered. There is a high degree of ciliary specialization, ranging from motile cilia of the respiratory epithelium to […]
An international collaborative research team, including scientists from UQ’s Queensland Brain Institute (QBI), has discovered a novel mechanism underlying memory involving rapid changes in a specific DNA structure. The team found that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls the activation and repression of genes underlying long-term memory formation. In addition, using advanced […]
Graphical abstract. Credit: Journal of Molecular Biology Scientists from St Petersburg University and the University of Montpellier have developed the first software enabling the prediction of pairs of proteins in amyloid fibrils capable of co-aggregation, i.e. a process by which proteins become attached to one another. Their studies have shown an accuracy of more than […]
Our proposed TORCH model framework. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-02915-w A large team of cancer researchers affiliated with several institutions in China, working with a pair of colleagues in the U.S., has found that artificial intelligence applications can be used to trace the origins of metastatic cancer cells in remote parts of the body. […]
Credit: Mayo Clinic Irritable bowel syndrome (IBS) can significantly disrupt a person’s daily life. Some people suffer in silence because of painful stomach cramps, diarrhea, and constipation. These symptoms can significantly affect a person’s quality of life. April 19 is World IBS Day, intended to raise awareness about IBS, which affects the stomach and intestines, […]
Myeloid expansion and transcriptional activation are features of chronic EAE. Credit: Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01609-3 Autoimmune conditions such as multiple sclerosis (MS) are disorders of the immune system associated in this case with demyelination of the central nervous system (CNS). The term demyelination describes damage to the layer covering nerve fibers in the brain […]
A systemic review of the current body of research shows that investigators have inadequately addressed the intersection of aging, health disparities, and cancer outcomes among older adults. This is the conclusion of a paper published in the Journal of the American Geriatrics Society, and led by Nikesha Gilmore, Ph.D., a member of Wilmot Cancer Institute […]
Credit: Kindel Media from Pexels A study conducted at the University of Gothenburg found that with dietary adjustments, more than 7 out of 10 irritable bowel syndrome (IBS) patients had significantly reduced symptoms, compared with medications. The work is published in The Lancet Gastroenterology & Hepatology journal. IBS is a common diagnosis that causes abdominal […]
Senior author Stephanie Crossen uses telehealth. Credit: UC Regents Grocery stores, airports and beaches aren’t great places to have telehealth visits with your endocrinologist. But home can be one of the best locations, giving a doctor helpful insights into a patient’s home environment, which can positively impact their care. This is just one finding shared […]
A new guideline from the American College of Physicians (ACP) offers clinical recommendations for the use of newer pharmacological treatments of adults with type 2 diabetes. This is an update of ACP’s 2017 guideline and is based on the best available evidence for effectiveness, comparative benefits and harms, consideration of patients’ values and preferences, and […]
A randomized controlled trial comprised of adults with obesity and prediabetes found that both time-restricted eating and a usual eating pattern resulted in weight loss when calories were held constant in both groups. It did not seem to matter whether participants consumed most of their calories early in the day or in the evening, suggesting […]
A large retrospective cohort pharmacoepidemiologic study found that despite approval by the U.S. Food and Drug Administration (FDA) for seven new gram-negative antibiotics between 2014 and 2019, clinicians in U.S. hospitals still treated more than 40% of patients battling highly resistant pathogens exclusively with older, generic agents. Furthermore, nearly 80% of the time these older […]
Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy. Now, a team led by researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania has found a big reason why. […]
In a new study published in Nature Biomedical Engineering, researchers at The University of Texas MD Anderson Cancer Center have designed a new method for developing immunotherapy drugs using engineered peptides to elicit a natural immune response inside the body. In preclinical models of locally advanced and metastatic breast cancer, this method improved tumor control […]
In a discovery that could hasten treatment for patients with multiple sclerosis (MS), UC San Francisco scientists have discovered a harbinger in the blood of some people who later went on to develop the disease. In about 1 in 10 cases of MS, the body begins producing a distinctive set of antibodies against its own […]
You hit the gym to get stronger, boost stamina and improve your health—but the gym is rife with bacteria and germs that cause everything from a common cold and the flu to athlete’s foot, ringworm and staph infections like MRSA. It’s essential to protect yourself from the hot spots at the gym with a powerful antibacterial spray […]
Inhibitory neurons (magenta) and their synapses (green) in the mouse neocortex. Credit: Biozentrum, University of Basel A sensitive perception of the environment is crucial for guiding our behavior. However, an overly sensitive response of the brain’s neural circuits to stimuli can lead to neurodevelopmental disorders such as epilepsy. University of Basel researchers report in the […]
Early-life injury can change how the body’s pain response system develops at a genetic level, leading to a pain “memory” that can affect response to injuries occurring years later, according to a study in Cell Reports published by experts at Cincinnati Children’s. Credit: Cell Reports and Cincinnati Children’s In recent years, a growing body of […]
Researchers at the University of Michigan Rogel Cancer Center have developed a new urine-based test that addresses a major problem in prostate cancer: how to separate the slow-growing form of the disease unlikely to cause harm from more aggressive cancer that needs immediate treatment. The test, called MyProstateScore2.0, or MPS2, looks at 18 different genes […]
Reticulon 3 (RTN3) expression is increased in the myocardium of patients with heart failure (HF) and mice with myocardial infarction (MI). (A) Transcriptional expression of RTN1, RTN2, RTN3, and RTN4. Credit: MedComm (2024). DOI: 10.1002/mco2.503 Heart failure (HF) after myocardial infarction (MI) is a global health issue with a high mortality rate. Multiple molecular mechanisms […]
The severely invasive nature of combat trauma creates massive regions of injury, colonization and infection, requiring specialized diagnostic and aggressive therapeutic approaches. Previous reports indicate an estimated occurrence of wound infections in 18%–25% of combat-related injuries. Hindering wound recovery are multidrug-resistant microorganisms, which have been consistently observed in injured service members with reports throughout the […]
Credit: cottonbro studio from Pexels Now we’re seeing a rise in stories about “Ozempic babies,” where women who use drugs like Ozempic (semaglutide) report unexpected pregnancies. But does semaglutide (also sold as Wegovy) improve fertility? And if so, how? Here’s what we know so far. Remind me, what is Ozempic? Ozempic and related drugs (glucagon-like […]
Metabolic health (normal blood pressure, blood sugar and cholesterol levels, among other factors) influences the effectiveness of influenza vaccinations. Vaccination is known to be less effective in people with obesity compared to those with a healthier body mass index (BMI), but St. Jude Children’s Research Hospital scientists have found it is not obesity itself, but […]
Many people eat a plant-based diet for health benefits and cultural and religious beliefs, while others just enjoy the savory taste of fruits and vegetables. However, there are some people who shy away from a plant-based diet because of misconceptions. Dr. Christine Nguyen, a Mayo Clinic family physician, talks about myths surrounding plant-based diets. Vegetarian […]
Are you tormented by an exaggerated fear of harming your child? Relax—it’s common, and research shows that it’s also treatable. You’re holding your newborn baby in your arms when the thought pops into your head—what if you happened to throw your baby out of the window? You get scared and wonder if you’re losing your […]
Researchers from Shibaura Institute of Technology, Japan investigated the impact of HFSD on mice and found that tocotrienols (T3s), a form of vitamin E, show promise in protecting against cognitive decline associated with obesity, highlighting its therapeutic potential. Credit: Yugo Kato from Shibaura Institute of Technology, Japan. Obesity has become a pressing worldwide health issue, […]
Credit: Sora Shimazaki from Pexels A new study published in Pain from the University of South Australia is putting people’s experiences of pelvic pain at the front of pain education to develop better pain management strategies and improved outcomes. Persistent pelvic pain is an umbrella term for pain in the pelvic area (below the belly […]
Gay and bisexual men who were diagnosed with mpox (formerly known as monkeypox) during the 2022 outbreak in England faced substantial issues related to stigma and potentially poor-quality care when accessing services, finds a new study led by UCL researchers. The research, published in eClinicalMedicine, examined for the first time the experiences of those diagnosed […]
Proposed spatial importance of B cells, plasma cells, TLS, and CAFs. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adk8805 Using spatial analysis of tissue samples, Cedars-Sinai investigators have identified patterns that could predict whether patients with the most common type of ovarian cancer will experience early relapse after treatment. These patterns, detailed in a study published in […]
University of Hawai?i Cancer Center researchers have conducted a phase II clinical trial investigating the potential of pembrolizumab maintenance therapy, a type of immunotherapy, in aggressive forms of breast cancer. The trial was led by Naoto T. Ueno, UH Cancer Center director, and Toshiaki Iwase, assistant professor and medical director, and was conducted at their […]
In this weekend’s London Marathon, nearly 50,000 runners will hit the capital’s streets in one of the world’s most iconic races. For the visually impaired (VI) runners on the start line, their approach to this famous route will differ from their sighted counterparts. Just as there are misconceptions about blindness itself, many people are confused […]
Credit: Rice University Mount Sinai researchers, in collaboration with scientists at The Rockefeller University, have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing systems. Published online in Science on April 18, these findings shed new light on the neural underpinnings of drug addiction and could offer […]
The neural process to suppress actions also plays an important role in a soccer player’s decision-making. Credit: Osaka Metropolitan University To pass or not to pass, that is the question faced by soccer players the world over in every match. It might be unsurprising that higher skilled players exhibit better execution of actions than lower […]
Vertex-wise comparisons between ADHD (N?=?60) and controls (N?=?23), and between ADHD responders (N?=?42) and non-responders (N?=?18). Credit: Nature Mental Health (2024). DOI: 10.1038/s44220-024-00228-y New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that the effectiveness of ADHD medication may be associated with an individual’s neuroanatomy. The research, […]
Advanced artificial intelligence (AI) systems have shown promise in revolutionizing the field of pathology by transforming the detection, diagnosis, and treatment of disease; however, the underrepresentation of certain patient populations in pathology datasets used to develop AI models may limit the overall quality of their performance and widen health disparities. A new study led by […]
The study revealed that children who show greater self-restraint and willingness to delay their gratification in their preschool years also tended to have better working memory and self-control which were linked to better academic skills and fewer behavioural and emotional problems two years later. Credit: Chen Luxi Suppose you were given a choice between having […]
Captain Robert Graves sees strangers every day as a pilot for Southwest Airlines. There’s not always a deep relationship with the people he works with or the people he meets. It’s a few constant people he may see, but even then, it may be months until he recognizes the co-pilot or flight attendants on his […]
A combo of an allergy drug and a blood pressure med appears to lower daily drinking in folks battling severe alcoholism, French researchers report. The two generic drugs are the antihistamine cyproheptadine and prazosin, which treats high blood pressure and urinary urgency, noted a team led by Henri-Jean Aubin, of the Université Paris-Saclay in Villejuif. […]
Nearly 20% of fresh, frozen and canned fruits and vegetables that Americans eat contain concerning levels of pesticides, a new report finds. Pesticides posed significant risks in popular choices such as strawberries, green beans, bell peppers, blueberries and potatoes, the review from Consumer Reports found. “One food in particular, green beans, had residues of a […]
Graphical abstract. Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.03.020 Non-small cell lung cancer accounts for nearly 85% of all lung cancer cases. Targeted immunotherapy is a common treatment, but it does not work for everyone. However, a new Moffitt Cancer Center study published in the journal Immunity offers insight into how lung cancer cells evade the protective […]
Overall survival and treatment schema in study patients. A Overall survival in responders (CR complete responders, PR partial responders) versus non-responders (NR) following VST therapy (n?=?51, survival curves were compared by log-rank test, p?=?1.06?×?10?7). B Overall survival by patient acuity following VST infusion for Arm A (n?=?47, p?=?0.0017). High acuity was defined as infusion in […]
In rural Kenya, 64-year-old John Kamau’s world of silence is about to change. For decades, isolated by hearing loss from the community’s vibrant life and his grandchildren’s conversations, he sees hope when a community health worker visits with a smartphone in hand. This isn’t just any visit; it’s the gateway to Kamau’s reconnection with the […]
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI169562 New RNA-targeted therapy can halt the progression of a specific type of childhood dementia in mice and holds potential to reverse some of the detrimental effects of this rare disease. Scientists from the University of Sydney’s Charles Perkins Center and the School of Life and Environmental Sciences […]
Credit: Tessy Agbonome from Pexels The complex interplay of rising temperatures and exposure to polluting compounds and chemicals can damage children’s hearts, experts have warned. Experts at the University of Exeter have contributed to a new statement from the American Heart Association (AHA). The statement explores the impacts of global warming, maternal heat exposure, airborne […]
Researchers from St George’s, University of London have identified key barriers to vaccine uptake for whooping cough, flu and COVID-19 in pregnant women, and outline recommendations for addressing vaccine hesitancy. The results are from the first review of its kind and are published in the journal PLOS ONE. Pregnant women are at increased risk of […]
Experimental setup for multi-patch experiments that record the activity of up to ten neurons. Credit: Charité | Yangfan Peng Contrary to previous assumptions, nerve cells in the human neocortex are wired differently than in mice. Those are the findings of a new study conducted by Charité-Universitätsmedizin Berlin and published in the journal Science. The study […]
Glutamine promotes proliferation, migration, and EndMT through ITGB4 in HBMECs. (A) Kyoto Encyclopedia of Genes and Genomes enrichment analysis of HBMECs treated with glutamine. (B) RT-qPCR analysis of ITGB4 expression in HBMECs treated with glutamine. (C) Proliferation ability of HBMECs subjected to glutamine treatment and ITGB4 knockdown assessed by CCK8 assay. (D) Representative images of […]
An innovative health care program developed by researchers at the University of Ottawa has successfully paired residents with family physicians at a time when Canada is lagging behind comparable, high-income countries in providing access to primary care providers. This recent publication in the Canadian Journal of Rural Medicine demonstrates the success of Integrated Virtual Care […]
Fresh organic basil tainted with salmonella and sold by Trader Joe’s in 29 states has sickened at least 12 people, according to an alert issued Wednesday by the U.S. Centers for Disease Control and Prevention. One person was so ill that hospitalization was required. “Throw away any Infinite Herbs organic basil purchased from Trader Joe’s,” […]
Parents of children with unilateral congenital cataracts (UCC) may wonder how long to patch, and whether extended periods of patching might affect their child’s development or cause undue stress for the child or family, particularly among children with poor vision in the treated eye. A first-of-its-kind study has now found that families whose children have […]
A movement to discredit a controversial medical diagnosis is being bolstered by a new study out of McGill University. Excited delirium describes a state of agitation, aggression, and distress and has become a common defense to counter charges of police brutality. In the case of George Floyd, the syndrome was initially used as a legal […]
The results of a new study, utilizing the most recent data on adolescent substance use to evaluate the effect of recreational cannabis legalization and retail sales on youth’s use of cannabis, tobacco, and alcohol, appear in JAMA Pediatrics. The study authors—co-principal investigators Rebekah Levine Coley, a Lynch School of Education and Human Development professor; School […]
Young people living in deprived coastal areas are likely to become unhealthier young adults than those living in deprived inland communities, according to new research. The study, led by the University of Essex’s Centre for Coastal Communities, is thought to be the first of its kind to map the impact of living in a disadvantaged […]
Expression levels of FGFRs from rhesus frontal cortex (FC) in response to live and non-viable B burgdorferi. FC tissue explants exposed to either live or sonicated B burgdorferi for 4 hrs. were probed for FGFR1-3 expression levels by immunofluorescence. Tissue explants exposed to medium alone were used as controls. FGFR positive cells per frame were […]
Smoking among women under 45 from more advantaged social groups in England appears to have increased over the past decade, according to a new study by UCL researchers. The researchers focused on women between 18 and 45 as these are the ages when women are most likely to become pregnant and for whom smoking tobacco […]
With syphilis cases in U.S. newborns skyrocketing, a doctors group now recommends that all pregnant patients be screened three times for the sexually transmitted infection. The American College of Obstetricians and Gynecologists issued new guidance on Thursday saying the screening should be done at the first prenatal visit, during the third trimester and at birth. […]
Hemorrhagic complications are uncommon after cranial epilepsy surgery, according to a study published online April 12 in World Neurosurgery. Yong Liu, from the The First Affiliated Hospital of Xi’an Jiaotong University in China, and colleagues examined the incidence and grade of severity of hemorrhagic complications after cranial epilepsy surgery in a retrospective analysis involving patients […]
Payments (€) per 1000 population across member countries without superseding laws from 2017 to 2019. Note: Countries where companies are not required to disclose their payments on transparentmedtech.eu are considered ineligible. Credit: Health Policy and Technology (2024). DOI: 10.1016/j.hlpt.2024.100865 Joint replacements, pacemakers, surgical instruments, and sutures; medical devices are a staple of health care. New […]
Diagnosis and treatment of breast cancer place significant stress on survivors, their partners, and their relationships. A new study from researchers with Regenstrief Institute and Indiana University’s Schools of Nursing, Science, and Medicine is one of the first to examine the impact of relationship satisfaction and agreement between breast cancer survivors and their partners on […]
Primary series and booster dose model fit results. (A) Example individual model fits for the primary series (blue) and booster dose (orange) Anti-S trajectory data. Dashed lines for D1, D2, and D3 indicate timing of dose 1, dose 2, and dose 3, respectively. (B) Distribution of all individual half lives for primary series (blue) and […]
As climate change threatens another long hot summer for Americans, new data shows last summer’s record-breaking temperatures sent a rising number of people to emergency departments. The findings are published in the journal MMWR. Morbidity and Mortality Weekly Report. At special risk of heatstroke and other heat-related issues: Working-age Americans, who often found themselves far […]
Credit: Jsme MILA from Pexels In every family, there’s often one person who takes charge of everybody’s health care needs. Who makes sure everyone gets an annual health exam. That they get their teeth cleaned and their prescriptions filled. And that all the insurance claims get filed. If a child gets sick, this person stays […]
Credit: American Journal of Physiology-Lung Cellular and Molecular Physiology (2024). DOI: 10.1152/ajplung.00300.2023 Infants and children who have severe cases of respiratory syncytial virus (RSV) before age 2 are likely to have changes to their lung structure and function that could affect respiratory health later in life. The study, “Early-life pulmonary viral infection leads to long-term […]
Credit: Pixabay from Pexels Every year, thousands of children and adolescents aged 0–18 across Australia present to an emergency department (ED) or are hospitalized for an injury or poisoning incident. Injury hospitalizations are the third leading contributor to the burden of disease for children and adolescents aged 0–19 years. Injuries sustained during childhood can have […]
Credit: Tima Miroshnichenko from Pexels Telemedicine has come to play an important role in patient care, but without prompt congressional action, it may no longer be an option for millions of Americans. If allowed to expire at the end of this year, pandemic-era rules that enhanced access to telemedicine would make it harder for many […]
Graphical abstract Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114060 Twin studies have proven invaluable for teasing out the effects of both genetics and the environment on human biology. In a study published April 2 in Cell Reports, researchers studied pairs of twins to look at how the interplay of genetics and environment affect cognitive processing—the way […]
When a mouthful of water goes down the wrong pipe—heading toward a healthy person’s lungs instead of their gut—they start coughing uncontrollably. That’s because their upper airway senses the water and quickly signals the brain. The same coughing reflex is set off in people with acid reflux, when acid from the stomach reaches the throat. […]
Nearly a half-million health workers who stand to benefit from California’s nation-leading $25 minimum wage law could be in for a rude awakening if hospitals and other health care providers follow through on potential cuts to hours and benefits. A medical industry challenge to a new minimum wage ordinance in one Southern California city suggests […]
At first, there was no commonly understood terminology across scientific disciplines to describe the transmission of pathogens through the air. The World Health Organization on Thursday announced a new, catch-all terminology for pathogens that transmit through the air, erasing a distinction that caused dangerous confusion during the COVID pandemic. During the COVID-19 crisis the standoff […]
Colorized transmission electron micrograph of Avian influenza A H5N1 viruses. Credit: Public Domain The World Health Organization voiced alarm Thursday at the growing spread of H5N1 bird flu to new species, including humans, who face an “extraordinarily high” mortality rate. “This remains I think an enormous concern,” the UN health agency’s chief scientist Jeremy Farrar […]
Deep-seated racial and ethnic disparities persist in health care across the United States, even in states considered the most progressive, a new report shows. For example, California received a score of 45 for the care its health system provides Hispanic Americans. The Commonwealth Fund report gives each state a 0–to–100 score for each population group […]
Scientist Francine Teixeira performing research at FM-USPDNA vaccines are cheaper and potentially more efficient than inactivated or attenuated virus vaccines. Credit: Camilla Adan In Brazil, researchers at the University of São Paulo (USP) and the Pernambuco division of Oswaldo Cruz Foundation (FIOCRUZ) are developing a Zika vaccine. The formulation was tested on mice and found […]
UCLA researchers have discovered that certain rare, functional mutations in noncoding DNA were associated with genes linked to cancer pathways. Credit: ANIRUDH/Unsplash Some genes are known to drive cancer, and astonishing new research shows why: Mutations in the noncoding regions become functional, altering the abundance of messenger RNA, or mRNA, and potentially facilitating cell proliferation. […]
A family enters a tent set aside for cholera patients at a clinic in Harare, Zimbabwe, on Nov. 18, 2023. The World Health Organization has approved a new version of a widely used cholera vaccine that could help address a surge in cases that has depleted the global vaccine stockpile. In a decision last week, […]
For decades, Amina Tollin struggled with mysterious, debilitating pain that radiated throughout her body. A few years ago, when a doctor finally diagnosed her with polyneuropathy, a chronic nerve condition, she had begun to use a wheelchair. The doctor prescribed a blood infusion therapy that allowed Tollin, 40, to live her life normally. That is, […]
Treatment with rhEPO decreases the structural complexity of SST O-LM cells and PV-expressing interneurons in the hippocampal CA1 region. A Representative hippocampal image of GAD-EGFP mice showing a schematic of different structural analyses performed. B Treatment scheme and hippocampal area of analysis illustrated with different interneuronal subtypes and their communication with pyramidal neurons. C Analysis […]
Fine-scale genetic structure of the modern Japanese and its three ancestry origins. (A) Geographic regions in Japan from which the samples were recruited are described. (B) PCA analysis based on common variants with a minor AF (C) Rare variant–based PCA-UMAP analysis (D) ADMIXTURE analysis with K set to 3. (E) UMAP1 is negatively correlated with […]
Reconstitution of immune cell subsets at 24-months. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-47720-8 Biomarkers for long COVID that were present in patients at eight months have largely resolved by 24 months among a cohort of people who contracted COVID-19 during Australia’s first wave. Jointly led by the Kirby Institute at UNSW Sydney and St Vincent’s […]
Two siblings who have the only known mutations in a key gene anywhere in the world have helped scientists gain new insights that could help progress the search for new treatments in type 1 diabetes. Type 1 diabetes (also known as autoimmune diabetes) is a devastating and life-long disease, in which the patient’s immune cells […]
A study published in the scientific journal Addiction has found that people who are maltreated as children may be three times more likely to be admitted to hospital for alcohol and substance use disorders by the age of 40, compared with those who are not maltreated. The study used data from over 6,000 children born […]
Modeling of PHD inhibitors. Credit: Nature Cancer (2024). https://doi.org/10.1038/s43018-024-00761-w Scientists have found a potential treatment strategy for an aggressive type of leukemia by targeting enzymes used by cells to sense and adapt to oxygen levels. In findings published in Nature Cancer, researchers reveal that blocking these oxygen-sensing enzymes can significantly halt acute myeloid leukemia (AML) […]
Today, patients who receive an organ transplant need repeated surgical biopsies to test for acute cellular rejection (ACR) throughout their lifetimes. But a blood test for ACR could be on the horizon following the discovery of a promising biomarker. ACR occurs when a patient’s immune cells, known as T cells, begin attacking the transplanted organ. […]
Effect of the new risk factors on prediction of 10-year CVD absolute risk. Ten-year CVD risk predictions for men and women over different ages. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-02905-y Collaborative research, led from the University of Oxford and published today in Nature Medicine, has developed a new tool called QR4 that more accurately predicts […]