{"id":72320,"date":"2017-03-28T14:26:10","date_gmt":"2017-03-28T14:26:10","guid":{"rendered":"http:\/\/healthmedicinet.com\/news\/operations-involving-anaesthetic-could-cause-brain-damage\/"},"modified":"2017-03-28T14:26:10","modified_gmt":"2017-03-28T14:26:10","slug":"operations-involving-anaesthetic-could-cause-brain-damage","status":"publish","type":"post","link":"http:\/\/healthmedicinet.com\/news\/operations-involving-anaesthetic-could-cause-brain-damage\/","title":{"rendered":"Operations involving anaesthetic could cause brain damage"},"content":{"rendered":"<ul class=\"mol-bullets-with-font\">\n<li class=\"\"><strong>Researchers tested the effects of oxygen deprivation of people climbing Everest<\/strong><\/li>\n<li class=\"\"><strong>Mental activity of participants significantly declined for as long as 11 days<\/strong><\/li>\n<li class=\"\"><strong>This study might explain why people struggle to go back to work after surgery<\/strong><\/li>\n<\/ul>\n<p class=\"author-section byline-plain\">By<\/p>\n<p>Phoebe Weston For Mailonline<\/p>\n<p class=\"byline-section\"><span class=\"article-timestamp article-timestamp-published\"><br \/><span class=\"article-timestamp-label\">Published:<\/span><br \/>\n  06:03 EDT, 28 March 2017<br \/><\/span><br \/>\n | <span class=\"article-timestamp article-timestamp-updated\"><br \/><span class=\"article-timestamp-label\">Updated:<\/span><br \/>\n  06:34 EDT, 28 March 2017<br \/><\/span>\n<\/p>\n<ul>\n<li class=\"share-facebook\"><\/li>\n<li class=\"share-twitter\"><\/li>\n<li class=\"share-pinterest\"><\/li>\n<li class=\"share-gplus\">\n      <span class=\"g-interactivepost\"><br \/><a><\/a><br \/><\/span>\n        <\/li>\n<li class=\"share-email\">\n<p>                <span class=\"wai\">e-mail<\/span><\/p>\n<\/li>\n<li class=\"share-icons\" id=\"shareLinkTop\">\n<\/li>\n<\/ul>\n<p> <span><\/span><\/p>\n<p class=\"count-number\">           1<\/p>\n<p class=\"count-text\">View <br \/> comments<\/p>\n<\/p>\n<p class=\"mol-para-with-font\">Surgery that involves taking anaesthetic might damage your brain for as long as 11 days, according to a landmark new study.<\/p>\n<p class=\"mol-para-with-font\">Researchers tested the mental damage of oxygen deprivation as a result of general anaesthetic\u00a0in an experiment which involved testing mountaineers climbing Everest.<\/p>\n<p class=\"mol-para-with-font\">They found the cognitive ability of participants declined for a sustained period of time after they came down from the mountain.<\/p>\n<p class=\"mol-para-with-font\">Experts believe this may explain why so many people have difficulty returning to work after a serious operation.<\/p>\n<p class=\"mol-para-with-font\"><span class=\"mol-style-bold\">Scroll down for video<\/span><\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" id=\"i-b74647291dc6d6b\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" height=\"421\" width=\"634\" alt=\"The research from City, University of London and University College London  might explain why so many people have difficulty returning to work after a serious operation\u00a0(stock)\" class=\"blkBorder img-share\" \/><br \/><img loading=\"lazy\" decoding=\"async\" id=\"i-b74647291dc6d6b\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/28\/10\/3EB3940100000578-4355868-image-a-1_1490692601020.jpg\" height=\"421\" width=\"634\" alt=\"The research from City, University of London and University College London  might explain why so many people have difficulty returning to work after a serious operation\u00a0(stock)\" class=\"blkBorder img-share\" \/><\/p>\n<p class=\"imageCaption\">The research from City, University of London and University College London  might explain why so many people have difficulty returning to work after a serious operation\u00a0(stock)<\/p>\n<h3 class=\"mol-factbox-title\">WHAT DID THEY DO?<\/h3>\n<p class=\"mol-para-with-font\">Participants took a neuropsychological (NP) test assessing memory, language and attention.<\/p>\n<p class=\"mol-para-with-font\">They did this at various different altitudes \u2013 sea level; 3,500 metres \u00a0at Namche Bazaar; 5,300 metres at Everest Base Camp and 1,300 metres at Kathmandu.<\/p>\n<p class=\"mol-para-with-font\">There was also a control group who were tested at sea level over the same period of time.<\/p>\n<p class=\"mol-para-with-font\">The Reliable Change Index (RCH) was used to calculate how their neuropsychological functions changed over the testing period.\u00a0<\/p>\n<p class=\"mol-para-with-font\">The effects of oxygen deprivation on the brain after climbing Everest were still present 11 days later when the climbers came back to Kathmandu.\u00a0<\/p>\n<p class=\"mol-para-with-font\">A side effect of taking anaesthetic is hypoxic brain damage which is caused by inadequate oxygen supply during the operation.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Symptoms, which affect one in five people, include  wheezing, high blood pressure and confusion.<\/p>\n<p class=\"mol-para-with-font\">However, this research found the brain damage could be much more prolonged than previously thought and last for several days.<\/p>\n<p class=\"mol-para-with-font\">The team used mountaineers to test the effect of oxygen starvation because it was unethical to intentionally deprive people of oxygen during an operation.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Research from City, University of London and University College London showed that there was a significant decline in mental activity for participants on their way down from the Everest peak,\u00a0where there is one third the level of oxygen than at sea level.<\/p>\n<p class=\"mol-para-with-font\">After the ascent, the 198 climbers that were tested failed nearly 20 per cent of tests which they could have done before climbing the mountain, writes the\u00a0Telegraph.\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">\n<ul class=\"rotator-panels link-bogr1 linkro-ccox\">\n<li>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/27\/21\/3EAFAE0900000578-0-image-a-51_1490645068556.jpg\" width=\"62\" height=\"60\" \/><span>The satellite system that could avoid another MH370: Radical\u2026<\/span><\/p>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/27\/14\/3EAE446000000578-0-image-m-66_1490622039908.jpg\" width=\"62\" height=\"60\" \/><span>YouTube in trouble AGAIN as more sick pranksters trick\u2026<\/span><\/p>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/28\/01\/3EAE1D3600000578-0-image-a-28_1490661569561.jpg\" width=\"62\" height=\"60\" \/><span>Monster millipede is found\u2026 in Wales: New species is\u2026<\/span><\/p>\n<p>          <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/28\/00\/3EB05A4A00000578-0-image-a-78_1490659166199.jpg\" width=\"62\" height=\"60\" \/><span>Why teenagers have no excuse for staying in bed: Youngsters\u2026<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"mol-para-with-font\">The Reliable Change Index (RCI) calculated the changes in cognition and psychological function during and after oxygen starvation, according to the paper published in Plos ONE.\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">Participants took a neuropsychological (NP) test assessing memory, language and attention.<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" id=\"i-2675231f0c2135cf\" src=\"image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" height=\"370\" width=\"634\" alt=\"The effects of oxygen deprivation on the brain after climbing Everest were still present 11 days later when the climbers came back to Kathmandu (stock) \u00a0\" class=\"blkBorder img-share\" \/><br \/><img loading=\"lazy\" decoding=\"async\" id=\"i-2675231f0c2135cf\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/28\/10\/3EB3940900000578-4355868-image-a-2_1490692708075.jpg\" height=\"370\" width=\"634\" alt=\"The effects of oxygen deprivation on the brain after climbing Everest were still present 11 days later when the climbers came back to Kathmandu (stock) \u00a0\" class=\"blkBorder img-share\" \/><\/p>\n<p class=\"imageCaption\">The effects of oxygen deprivation on the brain after climbing Everest were still present 11 days later when the climbers came back to Kathmandu (stock) \u00a0<\/p>\n<h3 class=\"mol-factbox-title\">TESTING OXYGEN DEPRIVATION<\/h3>\n<p class=\"mol-para-with-font\">The team used mountaineers to test the effect of oxygen starvation on the brain during surgery because it was unethical to intentionally deprive people of oxygen during an operation.\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">A side effect of taking anaesthetic is hypoxic brain damage which is  caused by inadequate oxygen supply during the operation.<\/p>\n<p class=\"mol-para-with-font\">As many as one in five people have hypoxic brain damage and symptoms include  wheezing, high blood pressure and confusion.<\/p>\n<p class=\"mol-para-with-font\">However, this research found that the brain damage could be much more prolonged than previously thought and last for several days after.<\/p>\n<p class=\"mol-para-with-font\">\n<p class=\"mol-para-with-font\">They did this at various different altitudes \u2013 sea level; 3,500 metres \u00a0at Namche Bazaar; 5,300 metres at Everest Base Camp and 1,300 metres at Kathmandu.<\/p>\n<p class=\"mol-para-with-font\">There was also a control group who were tested at sea level over the same period of time.<\/p>\n<p class=\"mol-para-with-font\">The effects of oxygen deprivation on the brain after climbing Everest were still present 11 days later when the climbers came back to Kathmandu.<\/p>\n<p class=\"mol-para-with-font\">The fact that oxygen deprivation has such a prolonged impact on the brain might explain why more people die coming down Everest than going up. \u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">\n<p class=\"mol-para-with-font\">Co-author Professor Stanton Newman, Dean of the School of Health Sciences at City believes that a similar thing might occur after taking anaesthetic for surgery.\u00a0<\/p>\n<p class=\"mol-para-with-font\">\u2018We know that a number of people who go back to work after surgery and find that they have cognitive problems but it was unclear what was causing it\u2019, he told the Telegraph.<\/p>\n<p class=\"mol-para-with-font\">\u2018We also noticed that the declines happened even when people were given oxygen and their oxygen levels returned to normal.\u2019<\/p>\n<p class=\"mol-para-with-font\">The volunteers were 60 per cent male and had an average age of 45.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Participants for the study were recruited from the general public. All volunteers were over 18, fluent English speakers, lowland residents and non-professional trekkers.\u00a0<\/p>\n<p class=\"mol-para-with-font\">\u2018By taking otherwise healthy individuals to Everest Base Camp our study has provided insight into how low oxygen environments impact on the human brain and body,\u2019 said Dr Newman.<\/p>\n<p class=\"mol-para-with-font\">\u2018We hope this study will give further insight into how we can respond to hypoxia-related cognitive impairment in clinical settings, particularly in older patients, in order to guide therapy and thereby minimise the magnitude and duration of impairment.\u2019<\/p>\n<p class=\"mol-para-with-font\">\n<p class=\"mol-para-with-font\">\n<p>            <!-- ad: http:\/\/mads.dailymail.co.uk\/v2\/us\/health\/none\/article\/other\/inread_player.html --><\/p>\n<h3 class=\"social-links-title\">Share or comment on this article<\/h3>\n<ul class=\"bigLinks sc-icns cleared\">\n<li class=\"share-facebook\">\n<p>                                    <span class=\"wai\">e-mail<\/span><\/p>\n<\/li>\n<li class=\"share-icons\" id=\"shareLinkBottom\">\n<\/li>\n<li id=\"addCommentButton\" class=\"add-comment\">\n<\/li>\n<\/ul>\n<p>            <!-- NOTE: WARNING: render-partial is a function --><\/p>\n<ul class=\"rotator-panels\">\n<li class=\"new shallow-ac mini link-bogr6 linkro-wocc\">  <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/i.dailymail.co.uk\/i\/pix\/2017\/03\/27\/13\/3EABE78900000578-0-image-a-57_1490616036969.jpg\" alt=\"Police officers in Plymouth, Devon, have been using a double-decker bus to try and catch motorists breaking the law\u00a0\" width=\"154\" height=\"115\" \/><span class=\"wocc bdrcc\">You\u2019ve been BUS-ted! 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