Everyone experiences stiff muscles from time to time, whether after a rigorous workout, in cold weather, or after falling asleep in an unusual position. People with cerebral palsy, stroke and multiple sclerosis, however, live with stiff muscles every single day, making everyday tasks such as extending an arm extremely difficult and painful for them. And since there isn\u2019t a foolproof way to objectively rate muscle stiffness, these patients often receive doses of medication that are too low or too high.<\/p>\n
Now, an interdisciplinary team of researchers at the University of California San Diego and Rady Children\u2019s Hospital has developed new wearable sensors and robotics technology that could be used to accurately measure muscle stiffness during physical exams. \u201cOur goal is to create a system that could augment existing medical procedures by providing a consistent, objective rating,\u201d said Harinath Garudadri, a research scientist at the university\u2019s Qualcomm Institute and the project\u2019s lead investigator.<\/p>\n
\u201cMany clinical exams and procedures are very subjective and rely on measurements that are done with a physician\u2019s hands,\u201d said Andrew Skalsky, director of the division of Rehabilitation Medicine at Rady Children\u2019s Hospital. \u201cWe often make major medical decisions and diagnoses based on touch and feel. With this technology, we can start to develop objective measurements for subjective processes.\u201d<\/p>\n
The level of muscle stiffness, known as spasticity, is typically evaluated using a six-point rating scale called the Modified Ashworth Scale. This scale is the current hospital standard, but it is subjective and often yields ratings that vary from one doctor to another. These ratings help dictate the dose of medication patients are prescribed to manage their spasticity. Inconsistent and inaccurate ratings can either lead to dangerous overdose or ineffective treatment as a result of doses that are too low.<\/p>\n
Patient feedback can also skew these ratings, Skalsky said. \u201cSometimes, patients think that they aren\u2019t getting enough medicine and end up being put on a higher dose than they should actually be on. That\u2019s thousands of dollars\u2019 worth of medicine that could potentially be saved.\u201d<\/p>\n
\u2018Sensored\u2019 glove<\/strong><\/p>\n Garudadri and Skalsky teamed up with electrical engineers and neuroscientists at UC San Diego to develop a glove equipped with sensors that is a more reliable tool and will enable doctors to come up with objective, accurate and consistent number ratings when evaluating spasticity in patients undergoing treatment.<\/p>\n The device is built on a regular sports glove that a doctor can wear while holding and moving a patient\u2019s limb back and forth. Taped onto the palm are more than 300 pressure sensors that measure the amount of force required to move a patient\u2019s limb. A motion sensor taped on the back measures how fast the limb is being moved. The glove is connected to a computer via USB.<\/p>\n Data from all the sensors are transmitted to the computer, where they are integrated, processed and mapped in real time using advanced signal processing algorithms developed by Garudadri\u2019s research group. The computer provides a numerical reading that calculates the actual power required to move a patient\u2019s limb-;the more power needed, the more severe the patient\u2019s spasticity.<\/p>\n \u201cWe\u2019re instrumenting the doctor instead of the patients,\u201d said Padmaja Jonnalagedda, an electrical engineering graduate student who worked on refining the algorithms. \u201cIt\u2019s more convenient for patients to not have to wear all these sensors all over their bodies. It\u2019s also more practical to equip just the doctor when you think about the large patient to doctor ratio, especially in developing nations or rural areas around the world,\u201d she said.<\/p>\n Researchers built another robotic device that they call the \u201cmock patient\u201d to serve as a control to validate their results. The mock patient consists of an artificial arm that can be moved up and down, simulating the flexing motion of an actual patient\u2019s arm. The artificial arm is connected to a rotating disc that can be manually adjusted to different resistance levels, like bike gears. The arm is embedded with its own set of sensors that measure the power needed to overcome the resistance and get it moving. Researchers can set the resistance, know the amount of power required to move the arm and then test whether the glove produces a matching result.<\/p>\n \u201cThe mock patient provides a ground truth to verify that what the glove is measuring is indeed a real number,\u201d said Fei Deng, an electrical engineering graduate student who was in charge of building the mock patient.<\/p>\n Objective touch<\/strong><\/p>\n In an initial study, two physicians trained in spasticity assessment were instructed to test the glove on five different patients with cerebral palsy. Each physician wore the glove while performing various movement tasks, including flexing and extending the patients\u2019 arms and legs. The physicians were asked to provide their own spasticity ratings according to the Modified Ashworth Scale, without knowing the readings from the glove. They also did not know what spasticity ratings the other was giving.<\/p>\n The research team compared the results. They found that only 27 percent of the physicians\u2019 spasticity ratings agreed with each other. By comparison, 64 percent of the measurements made by the glove agreed with the numbers generated by the mock patient. \u201cThis number needs to be higher if we want to deploy our system for use in the hospital, but it shows better consistency than existing spasticity assessments,\u201d Garudadri said.<\/p>\n \u201cThe multidisciplinary nature of our team is what makes this project so exciting and successful. Experts in signal processing, robotics, printable electronics, neurosciences and medicine came together to transform a subjective process into something that\u2019s objective and could improve patient care and outcomes,\u201d said Leanne Chukoskie, research scientist at the Institute for Neural Computation at UC San Diego.<\/p>\n Researchers say the technology could potentially be applied in other procedures where doctors have to rely on touch and feel to evaluate a patient\u2019s condition: monitoring spine health, assessing the severity of hip dislocation in infants, rehabilitation therapy, physical therapy, and more.<\/p>\n Next steps<\/strong><\/p>\n The team is seeking medical experts trained in spasticity assessment to test their system and provide feedback.<\/p>\n Researchers are also continuing to improve the system. Tina Ng, one of the electrical engineering professors on the project, is developing sensors that are more robust and can be directly printed onto the glove, rather than taped onto the surface like they are now. \u201cThis will make it easier to create different sizes of gloves,\u201d Ng said.<\/p>\n Michael Yip, an electrical engineering professor and a core member of the Contextual Robotics Institute at UC San Diego, is integrating haptics, or force feedback, into the new mock patient. \u201cNow, being able to actively push back on the doctor\u2019s arms and replaying real profiles of patients\u2019 spasticity on the simulator will allow doctors to improve their ability to assess and treat patients, and provide data to improve objective metrics from the glove,\u201d Yip said.<\/p>\n http:\/\/ucsdnews.ucsd.edu\/feature\/sensor_equipped_glove_could_help_doctors_take_guesswork_out_of_spasticity<\/p>\n","protected":false},"excerpt":{"rendered":" Everyone experiences stiff muscles from time to time, whether after a rigorous workout, in cold weather, or after falling asleep in an unusual position. People with cerebral palsy, stroke and multiple sclerosis, however, live with stiff muscles every single day, making everyday tasks such as extending an arm extremely difficult and painful for them. 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