{"id":84925,"date":"2017-09-20T18:10:28","date_gmt":"2017-09-20T18:10:28","guid":{"rendered":"http:\/\/healthmedicinet.com\/news\/pioglitazone-has-limited-effect-in-lipoatrophic-diabetes\/"},"modified":"2017-09-20T18:10:28","modified_gmt":"2017-09-20T18:10:28","slug":"pioglitazone-has-limited-effect-in-lipoatrophic-diabetes","status":"publish","type":"post","link":"http:\/\/healthmedicinet.com\/news\/pioglitazone-has-limited-effect-in-lipoatrophic-diabetes\/","title":{"rendered":"Pioglitazone has limited effect in lipoatrophic diabetes"},"content":{"rendered":"<article>\n<figure class=\"image-block\">\n<p>                <\/a><\/p>\n<\/figure>\n<p>(HealthDay)\u2014Pioglitazone may not be effective for lowering blood glucose levels, although it is associated with slight improvement in liver function, in lipoatrophic diabetes induced by juvenile dermatomyositis, according to a case report published online Sept. 12 in the <i>Journal of Diabetes Investigation<\/i>.\n                                <\/p>\n<p>Yusuke Baba, M.D., from the Chiba University Graduate School of Medicine in Japan, and colleagues present a case of lipoatrophic diabetes induced by juvenile dermatomyositis. A 19-year-old male was admitted for treatment of poorly controlled diabetes; he had been diagnosed with juvenile dermatomyositis at age 3, and was diagnosed with diabetes at age 9.<\/p>\n<p>The authors note that pioglitazone improved liver function<\/a> slightly, although it was not effective for lowering blood glucose levels<\/a>, with no change seen in blood glucose and hemoglobin A1c levels. Metreleptin was only administered for a short period, and consequently its effectiveness could not be ascertained. Burned-out nonalcoholic steatohepatitis was revealed on liver biopsy<\/a>.<\/p>\n<p>&#8220;Our results indicate that the successful treatment of lipoatrophic diabetes induced by juvenile dermatomyositis requires an early diagnosis and therapeutic intervention,&#8221; the authors write.\n                                                                <\/p>\n<p class=\"news-relevant\">\n                                        <img loading=\"lazy\" decoding=\"async\" class=\"toolsicon ic-rel\" src=\"https:\/\/b98584f181.site.internapcdn.net\/tmpl\/v5\/img\/1x1.gif\" width=\"14\" height=\"16\" alt=\"\" \/><\/a><br \/>\n                                        <b>Explore further:<\/b><br \/>\n                                        Ipragliflozin beneficial in T2DM complicated by liver disease<\/a>\n                                    <\/p>\n<p>\n                                        <b>More information:<\/b><br \/>\n                                        Abstract<\/a><br \/>Full Text<\/a><br \/>\n                                        <\/p>\n<footer class=\"post-floor clearfix\">\n                                    <!-- rating --><\/p>\n<p>                                                <img loading=\"lazy\" decoding=\"async\" class=\"toolsicon icon-fbck\" src=\"https:\/\/b98584f181.site.internapcdn.net\/tmpl\/v5\/img\/1x1.gif\" width=\"12\" height=\"12\" alt=\"feedback\" \/><br \/>\n                                                feedback to editors<br \/>\n                                            <\/a><\/p>\n<section class=\"copyright\">\n<p>\n\t\t\t\t\t    <img loading=\"lazy\" decoding=\"async\" alt=\"Healthday\" src=\"https:\/\/b98584f181.site.internapcdn.net\/tmpl\/v5\/img\/content\/HEALTHDAY_Web_small2.jpg\" width=\"80\" height=\"24\" \/>                                            Copyright \u00a9 2017 HealthDay<\/a>. All rights reserved.<br \/>\n\t\t\t\t\t<\/p>\n<\/section>\n<\/footer>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>(HealthDay)\u2014Pioglitazone may not be effective for lowering blood glucose levels, although it is associated with slight improvement in liver function, in lipoatrophic diabetes induced by juvenile dermatomyositis, according to a case report published online Sept. 12 in the Journal of Diabetes Investigation. Yusuke Baba, M.D., from the Chiba University Graduate School of Medicine in Japan, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-84925","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/posts\/84925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/comments?post=84925"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/posts\/84925\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/media?parent=84925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/categories?post=84925"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/tags?post=84925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}