Medicine, Health Care<\/a> 3-D-written Model to Provide Better\u2026<\/a> <\/a><\/a><\/a><\/a><\/p>\n
Published: March 5, 2018.
Released by Purdue University<\/a><\/p>\n
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WEST LAFAYETTE, Ind. — Purdue researcher Luis Solorio has helped create a lifelike cancer environment out of polymer to better predict how drugs might stop its course.<\/p>\n
Previous research has shown that most cancer deaths happen because of how it spreads, or metastasizes, in the body. A major hurdle for treating cancer is not being able to experiment with metastasis itself and knock out what it needs to spread.<\/p>\n
Studies in the past have used a 3-D printer to recreate a controlled cancer environment, but these replicas are still not realistic enough for drug screening.<\/p>\n
“We need a much finer resolution than what a 3-D printer can create,” said Solorio, an assistant professor of biomedical engineering.<\/p>\n
Rather than 3-D printing, Solorio and a team of researchers have proposed 3-D writing. The device that they developed, a 3-D jet writer, acts like a 3-D printer by producing polymer microtissues as they are shaped in the body, but on a smaller, more authentic scale with pore sizes large enough for cells to enter the polymer structure just as they would a system in the body.<\/p>\n
3-D jet writing is a fine-tuned form of electrospinning, the process of using a charged syringe containing a polymer solution to draw out a fiber, and then deposit the fiber onto a plate to form a structure. This structure is a scaffold that facilitates cell activity.<\/p>\n
Solorio has so far used the device to write a structure that drew in cancer cells to sites in mice where cancer would not normally develop, confirming that the device could create a feasible cancer environment. Solorio’s other studies have increased cancer cells in human samples for better analysis and maintained receptors on these cells that drugs would need to find.<\/p>\n
“Ideally, we could use our system as an unbiased drug screening platform where we could screen thousands of compounds, hopefully get data within a week, and get it back to a clinician so that it’s all within a relevant time frame,” Solorio said.<\/p>\n
Initial findings published on Feb. 27 in Advanced Materials<\/i> based on Solorio’s work as part of a team at the University of Michigan Biointerfaces Institute. He completed data analysis and writing while on faculty at Purdue.<\/p>\n
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Medicine, Health Care 3-D-written Model to Provide Better\u2026 Published: March 5, 2018.Released by Purdue University WEST LAFAYETTE, Ind. — Purdue researcher Luis Solorio has helped create a lifelike cancer environment out of polymer to better predict how drugs might stop its course. Previous research has shown that most cancer deaths happen because of how it […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-88255","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/posts\/88255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/comments?post=88255"}],"version-history":[{"count":0,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/posts\/88255\/revisions"}],"wp:attachment":[{"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/media?parent=88255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/categories?post=88255"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/healthmedicinet.com\/news\/wp-json\/wp\/v2\/tags?post=88255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}