IntroductionIn women with breast cancer who smoke, it is unclear whether smoking could impair their survival from the disease.
Methods:
We examined the relation of smoking at diagnosis to breast cancer-specific and overall survival among 5,892 women with invasive breast cancer treated in one Canadian center (1987 to 2008). Women were classified as never, former or current smokers.
Current smokers were further classified according to total, intensity and duration of smoking. Deaths were identified through linkage to population mortality data.
Cox proportional-hazards multivariate models were used. A systematic review with meta-analysis combines new findings with published results.
Results:
Compared with never smokers, current smokers at diagnosis had a slightly, but not statistically significant, higher breast cancer-specific mortality (hazard ratio = 1.15, 95% confidence interval (CI): 0.97-1.37).
Among current smokers, breast cancer-specific mortality increased with total exposure to, intensity and duration of smoking (all Ptrend
Smoking at diagnosis was associated with an increased all-cause mortality rate. A meta-analysis of all studies showed a statistically significant, 33% increased mortality from breast cancer in women with breast cancer who are smokers at diagnosis compared to never smokers (hazard ratio = 1.33, 95% CI: 1.12-1.58).
Conclusions:
Available evidence to date indicates that smoking atdiagnosis is associated with a reduction of both overall and breast cancer-specific survival.
Studies of the effect of smoking cessation after diagnosis on breast cancer-specific outcomes are needed.
Author: Sylvie BérubéJulie LemieuxLynne MooreElizabeth MaunsellJacques Brisson
Credits/Source: Breast Cancer Research 2014, 16:R42
Published on: 2014-04-19
Tweet
News Provider: 7thSpace Interactive
Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
There are no comments available. Be the first to write a comment.