HMN 2026: How E-cigarette devices expose users to toxic metals, mouse

A study published in Analytical and Bioanalytical Chemistry by University of Technology Sydney (UTS) researchers showed that even short-term vaping at exposure levels below typical daily human use resulted in measurable accumulation of toxic metals in lung tissue—including lead, copper and nickel.

Lead researcher Dr. Dayanne Bordin, a lecturer in analytical chemistry, said the pre-clinical study provides the first evidence that e-cigarette aerosols include metal-containing (organometallic) species, including those associated with tin and mercury—forms that are often more bioavailable and biologically reactive than inorganic metals.

“From a risk perspective, the findings reveal under-recognized hazards associated with vaping,” she said.

“Metal emissions and their biological effects are rarely incorporated into current safety assessments or public understanding. Unlike cigarettes, which are relatively consistent products, e-cigarettes and devices are often manufactured with poor quality control involving materials and components with unknown toxicological relevance.

“The metal profiles observed are consistent with emissions from heating coils and electrical components, identifying the device itself as a critical source of exposure and highlighting important gaps in how vaping risks are evaluated.”

Dr. Bordin explains this is important because many people believe vaping carries less risk than conventional cigarettes. This perceived reduction in harm, along with misleading marketing campaigns, has contributed to the rapid uptake of e-cigarettes globally, particularly among younger demographics. In Australia, for example, e-cigarette use among young adults increased from 5.3% in 2019 to over 21% in 2023, with a similar rise in adolescents.

“Our findings challenge the assumption that e-cigarettes are safer and shows how critical it is to review current vaping regulations, which should be expanded to include device-derived emissions, not just e-liquid composition,” she said.

“Vaping can deliver toxic metals directly into the lungs, even after short-term use. This information is important for anyone considering vaping, especially young people, because these metal exposures are largely invisible and rarely discussed.

“Specifically, there is a need for standards and routine testing of metal and organometallic emissions from e-cigarettes, particularly from heating coils and internal components,” said Dr. Bordin.

“The results also support updating risk assessment frameworks and public health guidance to incorporate metal exposure and bioaccumulation and improving consumer awareness around these previously unrecognized risks.”

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