The University of Michigan has published a web-based toolkit designed to support the use and implementation of Michigan’s new extreme risk protection order (ERPO) law. Also known as a red flag law, Michigan’s ERPO law went into effect in February with the goal of intervening when someone is at risk of using a firearm to […]
Medical students who report having a disability are less likely to match into a residency program, according to a new Yale study involving residency programs across the United States. The findings, researchers say, suggest students with disabilities may experience barriers to training and career opportunities, particularly in certain medical specialties. “Physicians with disabilities are underrepresented […]
Individuals with post-traumatic stress disorder (PTSD) undergo rapid transitions between neutral and negative emotional states, which are intensified by emotional numbing symptom severity, according to a study published online April 16 in JAMA Network Open. In a cross-sectional study, Nachshon Korem, Ph.D., from the Yale University School of Medicine in New Haven, Connecticut, and colleagues […]
Credit: Kindel Media from Pexels Certain demographic, clinical, and genetic factors heighten the risk for extraintestinal manifestations (EIMs) with inflammatory bowel disease (IBD), according to a study published online March 13 in Gastroenterology. Michelle Khrom, from Cedars-Sinai Medical Center in Los Angeles, and colleagues investigated the clinical, serologic, and genetic factors associated with EIM complications […]
In patients undergoing colonoscopy to screen for colorectal cancer, deeper sedation using the anesthetic drug propofol may improve detection of “serrated” polyps—a type of precancerous lesion that can be difficult to detect, reports a study in the online first edition of Anesthesiology. “Our study provides the first evidence that monitored anesthesia care with propofol might […]
AHEAD A3-45 Study sister trials with a common screening process. Randomization to A3-A45 after Stage 2 is dependent on levels of PET amyloid. CDR, Clinical Dementia Rating; CL, Centiloids; MMSE, Mini-Mental State Examination; PET, positron emission tomography; WMSR-LMS II, Wechsler Memory Scale-Revised Logical Memory Subscale II. Credit: Alzheimer’s & Dementia (2024). DOI: 10.1002/alz.13803 It’s long […]
A new study from the Texas A&M University School of Public Health uses national data on drug use and mental health to explore how workplace drug policies correlate with opioid use and misuse and psychological distress in American workers. The findings are published in the NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy. […]
The nursing work environment, nurse education, and staffing levels are independent factors affecting hospital scores on a key measure of patient-centered care—with significant implications for reimbursements, reports a study in Medical Care. “Our results provide evidence-based guidance about which modifiable aspects of hospital nursing are likely to improve patient experience ratings,” says Kathleen E. Fitzpatrick […]
The new draft of the global pandemic agreement has been released to countries ahead of Thursday’s deadline, with a more streamlined take on how the world should handle future pandemics. Rattled by COVID-19, which shredded economies, crippled health systems and killed millions, countries have spent two years trying to craft an international accord on pandemic […]
Measure of anxiety in TgF344-AD (Tg) and wild type (WT) rats. Credit: Aging (2024). DOI: 10.18632/aging.205741 A new research paper titled “The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats” has been published in Aging. Studies suggest that ketogenic diets (KD) may improve memory in […]
Credit: King’s College London As part of a joint study between King’s College London and Manchester Met, wearable headcams worn in real interactions and face decoding technology were used to read teens’ facial expressions, potentially uncovering hidden feelings and insights into relationships. Recordings of the adolescents’ facial expressions were run through new AI software to […]
The biochemical progression-free survival profiles of patients in the neoadjuvant chemohormonal therapy (NCHT) group and the neoadjuvant hormonal therapy (NHT) group. Credit: Journal of Urology (2024). DOI: 10.1097/JU.0000000000003876 For patients with locally advanced prostate cancer, combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen (PSA) levels, compared to hormonal therapy alone, […]
Not getting enough sleep is a common affliction in the modern age. If you don’t always get as many hours of shut-eye as you’d like, perhaps you were concerned by news of a recent study that found people who sleep less than six hours a night are at higher risk of type 2 diabetes. So […]
Thirunavukarasu found that the AI model GPT-4 significantly exceeds the ability of non-specialist doctors to assess eye problems and provide advice. Credit: University of Cambridge The clinical knowledge and reasoning skills of GPT-4 are approaching the level of specialist eye doctors, a study led by the University of Cambridge has found. GPT-4—a large language model—was […]
Telomere Length Assessment in CALERIE. Assessment of aTL with qPCR involves quantifying levels of telomeric DNA content relative to the number of genomes using the single copy gene IFNB1. Credit: Aging Cell (2024). DOI: 10.1111/acel.14149 Penn State researchers may have uncovered another layer of complexity in the mystery of how diet impacts aging. A new […]
— ARLINGTON HEIGHTS, Ill. (APRIL 17, 2024) – If you don’t have asthma, you might think all types of asthma look and act the same. You’d be wrong. There are many different types of asthma, and each has its own triggers – and all need to be kept under control. “May is Asthma and Allergy Awareness […]
Graphical Abstract. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114016 Cancer cells can change shape to travel around the body and spread (metastasize), but how they know when to do this has remained elusive. Researchers have now used a new technique to identify two genes that control how melanoma skin cancer cells change shape in response to […]
A growing body of research shows that exposure to air pollution, especially during pregnancy and childhood, may have a negative impact on brain development. Now a study led by the Barcelona Institute for Global Health (ISGlobal) has found that exposure to nitrogen dioxide (NO2) during the first two years of life is associated with poorer […]
The harder your brain works at your job, the less likely you may be to have memory and thinking problems later in life, according to a new study published in the journal Neurology. This study does not prove that stimulating work prevents mild cognitive impairment. It only shows an association. “We examined the demands of […]
Processing pipeline. Simple flow diagram displaying which imaging metrics contributed to which output metrics. Fiber density cross-section (FDC) was derived from WM-FODs as part of a fixel analysis pipeline, then summed voxel-wise as an intra-axonal volume fraction (AVF) estimate while T1W/T2W ratio was used as a myelin volume fraction (MVF) for the calculation of g-ratio […]
A co-culture of macrophages (unlabeled, white arrow for example) chewing away at a population of EGFR mutant lung cancer cells (green) in response to the combination therapy (EGFR inhibitor and a CD47-blocking antibody). Credit: The Weiskopf Lab/Whitehead Institute Through millions of years of evolutionary refinement, the human body has developed a sophisticated surveillance mechanism—the immune […]
Intestinal villus with myofibroblast progenitor cells (magenta) differentiate into smooth muscle fibers (cyan) that support dietary fat absorption. Credit: Kurpios Lab/Provided By discovering how a type of smooth muscle—which is essential for mechanical aspects of absorbing fats from food—forms in the gut, Cornell scientists have opened doors to making artificial muscle, repairing muscle following gut […]
This graphic shows how the large data set was narrowed down to identify 14 plasma metabolite biomarkers out of the millions of possibilities using a method called bidirectional Mandelian randomization. Credit: Professor Qiang SU, Department of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Guangxi, China Myocardial infarction, more commonly known as a heart attack, […]
A illustrates the course of the experiment. The first and the second Implicit Association Tests (IATs) were presented as one study (continuous line), while food stop-signal task (F-SST) and bogus taste test were presented as a second and separate study (dashed line). Participants were told that they needed to wait 20 min between the first and […]
“Guidance on Energy and Macronutrients Across the Lifespan” by Pennington Biomedical’s Dr. Steven Heymsfieldand (pictured speaking at ObesityWeek 2023), along with colleague Dr. Sue Shapses of Rutgers University was recently published in the New England Journal of Medicine. Credit: Ernie Ballard/PBRC In the long history of recommendations for nutritional intake, current research is trending toward […]
Polypharmacy, or the concurrent use of five or more medications, is common in older adults and increases the risk of adverse drug interactions. While deprescribing unnecessary drugs can combat this risk, the decision-making process can be complex and time-consuming. Increasingly, there is a need for effective polypharmacy management tools that can support short-staffed primary care […]
Probiotics have been touted as a treatment for everything from diarrhea to mental health disorders, with sales of probiotic supplements expected to exceed $65 billion globally in 2024. Plenty of consumers swear by probiotics, but there is little conclusive evidence that unequivocally supports their effectiveness for any particular health issue, and some Tufts experts agree […]
Quitting cigarettes during pregnancy may increase obesity-related complications for both parent and baby, but Rutgers Health researchers found that reductions in stillbirths and premature deliveries outweigh these dangers and speculated that nutrition counseling could increase the benefits. “Cigarettes are a powerful appetite suppressant, so quitters tend to gain considerable weight, particularly when they are still […]
The hippocampus-accumbens pathway is necessary for spatial reward memories. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-47361-x Picture this: You want to take a walk to your favorite ice cream parlor for the first time after winter. You can probably remember how to get there. How does our brain guide us to such rewarding places? In a […]
Graphical Abstract. Credit: iScience (2024). DOI: 10.1016/j.isci.2024.109583 Bacterial meningitis is a devastating infectious disease because, even when cured, most survivors live with permanent neurological disabilities such as motor impairment, cognitive delay, hearing and vision loss, seizures, and psychiatric disorders, due to neuronal damage caused by the infection. Researchers at Karolinska Institutet have now revealed new […]
The Spatial Computing theory posits that beta rhythms act like stencils, dictating where gamma rhythms can encode information in the cortex, for instance from the senses. Credit: MIT Picower Institute It could be very informative to observe the pixels on your phone under a microscope, but not if your goal is to understand what a […]
Multidimensional neural effect of acute ketamine administration. Credit: eLife (2024). DOI: 10.7554/eLife.84173 Since Yale researchers first observed the ability of the anesthetic ketamine to dramatically improve symptoms in many patients with treatment-resistant depression more than two decades ago, the drug has provided a powerful new therapeutic option for mental health professionals. However, only 65% of […]
Penn State researchers developed a robotic simulation training programing, pictured here, that allows medical residents to practice placing central lines under a variety of scenarios and receive immediate feedback. Credit: Michael Owen/Penn State More than five million central lines are placed in patients who need prolonged drug delivery, such as those undergoing cancer treatments, in […]
The lifetime risk of atrial fibrillation (a heart condition that causes an irregular and often abnormally fast heart rate) has increased from one in four to one in three over the past two decades, finds a study from Denmark in The BMJ today. And among those with the condition, two in five are likely to […]
By 2050, it is predicted that one in four people in the UK will be aged 65 years or over. We have seen increases in lifespan over the last number of decades; however, this is not necessarily complemented by increases in health, which is increasing strain on health and social care services. When we get […]
Overall, prescription opioid overdose ED visits of US children had a decreasing trend during the past decade. Credit: frolicsomepl, Pixabay, CC0 (creativecommons.org/publicdomain/zero/1.0/) The US saw a 22% decline in rates of prescription-opioid overdose related emergency department (ED) visits in children 17 and younger between 2008 and 2019, but an uptick in the early part of […]
Many people around the world make and eat fermented foods. Millions in Korea alone make kimchi. The cultural heritage of these picklers shape not only what they eat every time they crack open a jar but also something much, much smaller: their microbiomes. On the microbial scale, we are what we eat in very real […]
The CDC is investigating harmful botulism-like reactions in 19 people who received counterfeit or mishandled botulinum toxin (Botox), according to a new reportopens in a new tab or window. The FDA also issued its own alertopens in a new tab or window today, with information for healthcare providers on how to identify the counterfeit products. As of April […]
Phlebotomy technicians collect blood from patients and prepare the samples for testing. Most work in hospitals and clinics, but some collect blood for donation purposes. In this Mayo Clinic Minute, Dr. Fiona Craig, who oversees the Laboratory Medicine and Pathology Department at Mayo Clinic in Arizona, discusses the vital role phlebotomists play in blood collection. […]
Almost 70 percent of Twitter users reported being bullied, and Twitch was the second-highest social media platform linked to weight-related bullying, according to the new study. Credit: sweetlouise, Pixabay, CC0 (creativecommons.org/publicdomain/zero/1.0/) From a survey of about 12,000 adolescents from Australia, Canada, Chile, Mexico, the US, and the UK, about 17% of respondents reported experiencing weight-related […]
In the aftermath of the tragic Bondi knife attack, Joel Cauchi’s parents have spoken about their son’s long history of mental illness, having been diagnosed with schizophrenia at age 17. They said they were “devastated and horrified” by their son’s actions. “To you he’s a monster,” said his father. “But to me he was a […]
The US Food and Drug Administration (FDA) has approved the first-ever prescription app for major depressive disorder (MDD). The app, Rejoyn, was developed by Otsuka Pharmaceutical and Click Therapeutics. It will be available by prescription only to adults aged 22 years or older, under the care of a clinician, who are already taking antidepressant medications. […]
— CHICAGO — In patients undergoing colonoscopy to screen for colorectal cancer, deeper sedation using the anesthetic drug propofol may improve detection of “serrated” polyps — a type of precancerous lesion that can be difficult to detect, reports a study in the Online First edition of Anesthesiology, the peer-reviewed journal of the American Society of […]
The anticalcitonin gene-related peptide-receptor monoclonal antibody erenumab is effective and safe for treatment of rosacea-associated erythema and flushing, according to a study published in JAMA Dermatology. Nita K.F. Wienholtz, M.D., Ph.D., from Copenhagen University Hospital-Rigshospitalet in Denmark, and colleagues examined the effectiveness, tolerability, and safety of erenumab for treatment of rosacea-associated erythema and flushing in […]
Heritability for autism spectrum disorder (ASD) varies for males and females, with higher heritability seen for males than females, according to a study published online April 17 in JAMA Psychiatry. Sven Sandin, Ph.D., from the Karolinska Institutet in Stockholm, and colleagues estimated the sex-specific heritability of ASD in a population-based, retrospective analysis of nontwin siblings […]
A form of heart failure that occurs during late pregnancy or early postpartum, peripartum cardiomyopathy (PPCM) is a major cause of maternal death. New research led by investigators from Massachusetts General Hospital reveals new insights into the mechanisms behind PPCM’s development and points to potential new strategies for therapeutic development. The results are published in […]
A illustrates the course of the experiment. The first and the second Implicit Association Tests (IATs) were presented as one study (continuous line), while food stop-signal task (F-SST) and bogus taste test were presented as a second and separate study (dashed line). Participants were told that they needed to wait 20 min between the first and […]
Based on continuous monitoring of early recurrence of atrial tachyarrhythmia immediately after patients have undergone atrial fibrillation ablation, Musat et al. recommend shortening the blanking period from three months to one. Credit: Dan Musat New evidence-based research calls into question the conventional three-month blanking period immediately after atrial fibrillation (AF) ablation when early occurrences of […]
Women with triple-negative breast cancer, and high levels of immune cells in the tumors, have a lower relapse risk after surgery, even without chemotherapy, according to a recent study published in JAMA. Triple-negative breast cancer accounts for about 15% of all breast cancer diagnoses worldwide. Compared to other breast cancers, those affected are younger and […]
Radio ads with an emotional appeal—featuring personal stories of either a happy organ transplant recipient or a sad patient languishing on the waiting list—increase non-donor listeners’ support for organ donation and may be effective at overcoming some of the qualms that deter them from joining the donor registry, a new study suggests. The research is […]
Two implanted heart devices used by patients in end-stage heart failure are now under a strict U.S. Food and Drug Administration recall, after being tied to 273 known injuries and 14 deaths, the agency said Tuesday. The HeartMate II and HeartMate 3 are manufactured by Thoratec Corp., a subsidiary of Abbott Laboratories. About 14,000 of […]
Dana-Farber Cancer Institute in Boston, MA. Credit: Dana-Farber Cancer Institute For the first time in fifty years, results from a Phase 3 randomized, placebo-controlled trial have shown an overall survival benefit from an adjuvant therapy in patients with kidney cancer. Treatment with pembrolizumab, an immunotherapy drug, after surgery significantly prolonged overall survival in patients with […]
Flow chart (PRISMA 2020) for the screening and selection of articles. Credit: Nurse Education in Practice (2023). DOI: 10.1016/j.nepr.2023.103614 About 60 percent of nurses with less than two years’ work experience are uncomfortable with performing procedures of higher complexity—such as responding to a critical clinical emergency, performing tracheostomy (a surgically created hole in the windpipe) […]
Protecting men who have sex with men against gonorrhea with the 4CMenB meningococcal B vaccine is cost-effective; Imperial College London study finds Gonorrhea is a sexually transmitted disease which is caused by infection with the Neisseria gonorrhoeae bacterium. Previous studies showed that the 4CMenB meningococcal vaccine (also called Bexsero) partially protects against gonorrhea. This mathematical […]
Sulfadoxine-pyrimethamine (SP) retains parasitological activity and remains effective for preventing P. falciparum infection in pregnant women and low birth weight in babies, even in areas with a high prevalence of mutations associated with SP resistance. This is the main conclusion of a study conducted in southern Mozambique and led by the Manhiça Health Research Institute […]
The outline of a person and their brain facing a cannabis leaf and symbolic CBN pill, demonstrating the potential for CBN to treat neurological disorders in the future. Credit: Salk Institute One in every 10 individuals above the age of 65 develops an age-related neurological disorder like Alzheimer’s or Parkinson’s, yet treatment options remain sparse […]
Antipsychotic use in people with dementia is associated with elevated risks of a wide range of serious adverse outcomes including stroke, blood clots, heart attack, heart failure, fracture, pneumonia, and acute kidney injury, compared with non-use, finds a study published by The BMJ today. These findings show a considerably wider range of harms associated with […]
Rates of early death and poor health caused by HIV/AIDS and diarrhea have been cut in half since 2010, and the rate of disease burden caused by injuries has dropped by a quarter in the same time period, after accounting for differences in age and population size across countries, based on a new study published […]
Opioid dependence in Scotland remains high but largely stable, according to a new University of Bristol-led analysis published in Addiction. The study is the first to estimate the number of people dependent on opioid drugs (such as heroin), and who are in or could benefit from drug treatment, among Scotland’s population since 2015/2016 estimates were […]
A new research study out of the University of Toronto sheds light on the intricate relationship between conformity to masculine gender norms and muscle dysmorphia symptomatology among a diverse sample of Canadian adolescents and young adults. The study titled “Masculinity and muscle dysmorphia in mixed gender Canadian youth” was published in the journal Sex Roles. […]
Searching for evidence for health technology assessments (HTAs) is time-consuming because the evidence identified must be a reliable basis for robust assessment results: The scientific knowledge about the benefits and harms for patients must be completely available. This is why IQWiG’s information specialists regularly review the effectiveness and efficiency of information retrieval conducted for the […]
Credit: Lynn Greyling/public domain Bariatric surgery has emerged as an effective means of reducing weight in morbidly obese individuals, while also significantly improving diabetes. Currently, laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) are two of the most commonly performed bariatric surgeries. Both LSG and RYGB can result in weight loss as well as […]
The interplay between the food we eat and our overall cognitive performance is a topic of increasing interest to people throughout the world. And while some studies have reported benefits of healthy diet patterns on cognitive performance, the results of these individual studies remain inconsistent. A new study published in Frontiers in Nutrition seeks to […]
For patients undergoing carpometacarpal (CMC) joint surgery for treatment of thumb osteoarthritis, the use of online video instruction for postoperative hand therapy is associated with outcomes similar to in-person therapy visits—while substantially reducing travel time and distance, reports a clinical trial in in the Journal of Bone & Joint Surgery. Video-administered hand therapy provides an […]
Many consumers know the food safety risks of dairy products, eggs and raw meat. But they are less likely to understand the risks associated with dry goods, including tree nuts such as almonds, cashews, walnuts and pistachios, said Yaohua “Betty” Feng, associate professor of food science at Purdue University. “We dry food products to extend […]
COVID boosters are now available to purchase from high-street pharmacies and private health care providers in England. This means that millions of people who don’t qualify for a free COVID vaccine on the NHS will be able to access one. But this recent announcement has also raised concerns about both the cost and accessibility of […]
As the UK grapples with the worst cost-of-living crisis in decades, a new study has shed light on household spending habits. The University of Portsmouth led research examined data from the Office for National Statistics (ONS) to track spending trends from 1985 to 2019. Using both cross-section and time-series data from the Family Spending workbooks […]
— Cardiovascular diseases, including stroke and myocardial infarction, are the world’s leading causes of mortality, accounting for over 18 million deaths a year. A team of KIT researchers has now identified a new cell type in blood vessels responsible for vascular growth. This discovery may allow for novel therapeutic strategies to treat ischemic cardiovascular diseases, […]
— Chattering squirrels, charming coypus, and tail-slapping beavers — along with some other rodents — have orange-brown front teeth. Researchers have published high-resolution images of rodent incisors in ACS Nano, providing an atomic-level view of the teeth’s ingenious enamel and its coating. They discovered tiny pockets of iron-rich materials in the enamel that form a […]
— By analyzing electronic health records, researchers at University of California San Diego School of Medicine have identified hundreds of new genes associated with tobacco use disorder. They also identified hundreds of potential drug candidates that could help treat the disease. The study was published on April 17, 2024, in Nature Human Behavior. “Tobacco use […]
Our possessions—the things we view as “mine”—play an important role in our lives. Beyond their functionality, they can serve as poignant reminders of cherished memories. They can symbolize not only who we are, but also who we used to be, and who we aspire to become. From faded photo albums to treasured jewelry passed down […]
Newswise — Quitting cigarettes during pregnancy may increase obesity-related complications for both parent and baby, but Rutgers Health researchers found that reductions in stillbirths and premature deliveries outweigh these dangers and speculated that nutrition counseling could increase the benefits. “Cigarettes are a powerful appetite suppressant, so quitters tend to gain considerable weight, particularly when they […]
A health insurance operation based in Broward County, Florida, used internet ads that falsely promised cash subsidies to sign up clients across the country and replace their agents, a lawsuit contends. The scheme was carried out by Enhance Health LLC, TrueCoverage LLC, Speridian Technologies LLC, Number One Prospecting LLC and two individuals who ran it, […]
A comparison of treatments for malnutrition enteropathy, caused by severe acute malnutrition (SAM), has found evidence supporting the use of treatments to enhance the healing of mucosal membranes and reduce inflammation in the gut to improve the outcomes of children affected by long-term health consequences of a period of malnutrition. The Therapeutic Approaches to Malnutrition […]
Researchers have found that children of women with HIV infection have an increased risk of immune abnormalities following exposure to maternal HIV viremia, immune dysfunction, and co-infections during pregnancy. The research is published in Nature Communications. The study, led by Dr. Ceri Evans while at Queen Mary University of London, compared clinical outcomes between infants […]
The typical average adult head weighs approximately 10–12 pounds. But did you know that bending it forward at a 45-degree angle to look at a cellphone or tablet can dramatically increase your chances to have “tech neck?” “That’s like having an 8-pound bowling ball as your head. Then you have 72 pounds at your elbow […]
A wide-ranging lawsuit filed April 12 outlines a moneymaking scheme by which large insurance sales agency call centers enrolled people into Affordable Care Act plans or switched their coverage, all without their permission. According to the lawsuit, filed in U.S. District Court for the Southern District of Florida, two such call centers paid tens of […]
Regina Barrett, a 69-year-old retiree who lives in this small North Carolina city southeast of Charlotte, has not been happy with her tap water for a while. “Our water has been cloudy and bubbly and looks milky,” said Barrett, who blames fluoride, a mineral that communities across the nation have for decades added to the […]
image: Freddie Jennings view more Credit: University Relations Anyone who regularly watches news or sports has likely noticed the steady creep of content competing for screen space, whether it be stock market prices, social media posts, game scores or some other graphic display. Previous studies have indicated that high intensity visuals that employ vibrant displays […]
Sixth-grade boys were lining up to be measured in the Mann Arts and Science Magnet Middle School library. As they took off their shoes and emptied their pockets, they joked about being the tallest. “It’s an advantage,” said one. “You can play basketball,” said another. “A taller dude can get more girls!” a third student […]
Waltham — March 15, 2024 — For patients undergoing carpometacarpal (CMC) joint surgery for treatment of thumb osteoarthritis, the use of online video instruction for postoperative hand therapy is associated with outcomes similar to in-person therapy visits – while substantially reducing travel time and distance, reports a clinical trial in The Journal of Bone & Joint Surgery. The journal is published in the […]
Two-thirds of homeless people are experiencing some form of mental health disorder, a large, new review of data on the subject. The analysis found that men who are homeless are more likely to be battling mental illness than women, although rates were high for both genders compared to the general population. There are signs that […]
Zepbound, one of the wildly popular weight-loss drugs that millions of Americans now take, eased sleep apnea in obese adults in two company trials, drug maker Eli Lilly announced Wednesday. First approved to treat obesity by the U.S. Food and Drug Administration last November, Zepbound’s power was significant: It reduced sleep apnea severity by nearly […]
Overview of the cohorts, analysis pipeline and genetic correlations among the sites. Credit: Nature Human Behaviour (2024). DOI: 10.1038/s41562-024-01851-6 By analyzing electronic health records, researchers at the University of California San Diego School of Medicine have identified hundreds of new genes associated with tobacco use disorder. They also identified hundreds of potential drug candidates that […]
A lot of people think of hoarding as something extreme—a home crammed to the ceiling with possessions. But it tends to start gradually, and research has found it can begin in adolescence or even childhood. The information people have about it often comes from documentaries about severe cases, focusing on overflowing piles of possessions. But […]
Variability of FG. a, A schematic definition of a valid morning window. The x axis depicts time: the minor ticks, month-day hour; the major ticks, hour:min. b, Progression of the mean FG (mg?dl?1) with age (years). The dots show the distribution of the data points. Dotted black lines show the 3rd, 10th, 50th, 90th and […]
scRNA-seq reveals an enrichment of OXPHOS-associated genes in IL10-expressing B cells. a, UMAPs showing B cell clusters and phenotypic identities ex vivo (left) and following stimulation for 72?h with CpGC (right). b, Dot plots showing the expression of indicated genes in each subset ex vivo and following CpGC stimulation. c, UMAP and graph showing analysis […]
Determining how genetics contribute to common forms of strabismus has been a challenge for researchers. Small discoveries are considered meaningful progress. Boston Children’s researchers believe they’ve helped move the needle. They discovered that two types of strabismus—esotropia and exotropia—may have shared genetic risk factors. Duplications on the second, fourth, and tenth chromosomes that were present […]
Cedars-Sinai investigators have discovered how brain cells responsible for working memory—the type required to remember a phone number long enough to dial it—coordinate intentional focus and short-term storage of information. The study detailing their discovery was published in Nature. “We have identified for the first time a group of neurons, influenced by two types of […]
Washington University senior clinical research coordinator Brittany Nelson (front) helps study participant Adam Kloppenburg get a brain scan as part of a study on the intersection of Down syndrome and Alzheimer’s disease. Researchers at Washington University School of Medicine in St. Louis have discovered that Alzheimer’s disease starts earlier and moves faster in people with […]
The U.S. Food and Drug Administration has approved an additional indication for AstraZeneca’s Fasenra (benralizumab) as an add-on maintenance treatment for patients aged 6 to 11 years with severe asthma and an eosinophilic phenotype. This indication was supported by evidence from the Phase III TATE trial, as well as data from additional well-controlled trials in […]
Some people with tough-to-treat epilepsy might benefit if doctors target a brain region newly linked to the disorder, a new study suggests. Seizures declined by 83% after a patient underwent surgery that removed almost all of the fasciola cinereum, a previously overlooked region of the hippocampus, researchers report April 17 in the journal Nature Medicine. […]
IHC staining for anti-inflammatory mediators PPAR-? indicative of butyrate presence. Credit: International Journal of Molecular Sciences (2023). DOI: 10.3390/ijms25010539 A team of researchers at the University of Missouri is uncovering how the juice from red cabbage, long used in traditional medicine, can alleviate inflammation-associated digestive health conditions such as inflammatory bowel disease (IBD) in mice, […]
Comprehensive cMVBA identifies cell-type-resolved and region-specific mosaic variants. Credit: Nature (2024). DOI: 10.1038/s41586-024-07292-5 A group of researchers at University of California San Diego School of Medicine led an investigation that offers new insight into the development of the human forebrain. The study, led by Changuk Chung, Ph.D., and Xiaoxu Yang, Ph.D., both from the laboratory […]
Over 100,000 people in the U.S. are waiting for an organ transplant. Unfortunately, many may never get the call saying that a suitable donor organ—and a second chance at life—has been found. It’s estimated that more than 15 people die every day in the U.S. because of the lack of donor organs. It can be […]
The Biovotion Everion wearable device we used to collect physiological and behavioral sensor data over the day. Image: Infinity Design. Credit: npj Digital Medicine (2024). DOI: 10.1038/s41746-024-01025-8 Multiple sclerosis (MS) is an insidious disease. Patients suffer because their immune system is attacking their own nerve fibers, which inhibits the transmission of nerve signals. People with […]
Impact of paternal diets on F0 metabolic phenotypes. Macronutrient composition (% energy) of paternal treatment diets and map showing location of each diet in the nutrient space plotted as a right angled mixture triangle. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-46782-y A study of mice suggests a father’s diet may shape the anxiety of his sons […]
Active TCMR is uniquely characterized by expansion of Treg and PD1+CD4+ T cells. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm8841 Children with liver transplants must take immunosuppressant medications for life. To maintain tolerance of the transplanted liver, doctors treat transplant rejection and conduct ongoing maintenance immunosuppression by increasing dosages of medication enough to counteract rejection. Children’s […]
Neural responses altered by deep brain stimulation. a, Schematic of DBS leads placement in 5 patients with treatment-resistant depression. b–d, Data from the control group are shown again here as a reference (gray), but not included in the statistical analysis. Credit: Nature Mental Health (2024). DOI: 10.1038/s44220-024-00238-w One potential underlying cause of symptoms in individuals […]
Graphical abstract showing how layer 6b changes brain state and acts on neural circuits by way of an analogy to a car accelerator pedal. Orexin “pushes” down the accelerator pedal (activates layer 6b), which causes the car engine cylinders (the higher-order thalamocortical system/loop) to cycle faster and faster until the car, which represents brain state, […]