Yo-yo dieting could increase your risk of dementia, a new study warns. 

The medical community has long advised people to keep their levels of ‘bad cholesterol’ from fatty and sugary foods to a minimum. 

But new research suggests that letting those levels fluctuate by crash dieting could also have devastating consequences. 

According to experts at the American Heart Association, fluctuations affect blood flow to the brain – a process which could lead to memory loss and even Alzheimer’s. 

Dangerous? New research suggests that letting levels of bad cholesterol fluctuate by crash dieting could have just as devastating consequences as constantly high levels of bad cholesterol 


A landmark study has identified the first physiological sign of late-onset Alzheimer’s.

Contrary to previous understanding, brain scans show a decrease in blood flow through the brain is the earliest indicator that a patient has the disease.

An increase in amyloid protein was thought to be the number one sign.

But while amyloid plays a role, experts at the Montreal Neurological Institute and Hospital have determined that blood flow decreases first in the most thorough study ever published on Alzheimer’s.

They also found that changes in cognition begin earlier than previously thought.

The study, led by Dr Alan Evans, has provided the most complete maps of the disease to date. 

‘Our findings suggest for the first time that it’s not just the average level of your LDL-cholesterol that is related to brain health, but also how much your levels vary from one measurement to another,’ lead author Roelof Smit, a Ph.D. student at Leiden University Medical Center, said.

In a study of European adults age 70 to 82 years old, researchers found that greater fluctuations in low-density lipoprotein cholesterol (LDL), or ‘bad’ cholesterol, are associated with lower cognitive performance.

For example, study participants with the highest LDL cholesterol variability took 2.7 seconds longer on average to finish a cognitive test to name ink colors of color words written in different ink (for example, the word blue written in red ink), compared to individuals with the lowest variability.

‘While this might seem like a small effect, it is significant at a population level,’ said Smit.

The link between variability and declining cognitive function was found regardless of average bad cholesterol levels or use of cholesterol-lowering statin drugs.

In addition, greater fluctuations in bad cholesterol were associated with lower brain blood flow and greater white matter hyperintensity load – which has been linked to endothelial dysfunction.

These results show LDL cholesterol variability may be important to neurocognitive function, Smit said. 

Measurements fluctuate because of diet, exercise, frequency of cholesterol-lowering statins and other factors, he said. 

However, these fluctuations might also reflect an increasingly impaired homeostasis.

For example, due to age or underlying disease, added J.Wouter Jukema, M.D., Ph.D., senior author of the study and professor of Cardiology at the Leiden University Medical Center.

The research, published in the American Heart Association’s journal Circulation, involved 4,428 participants from Scotland, Ireland and the Netherlands in the PROspective Study of Pravastatin in the Elderly at Risk.

PROSPER participants either had preexisting vascular disease or were at a higher risk for developing the condition because of histories of hypertension, cigarette smoking or diabetes.

Researchers examined associations between LDL cholesterol variability and four cognitive measures: color-word test for selective attention, letter-digit coding to assess information processing speed and picture-word learning to test verbal memory in two ways – immediate recall and delayed recall after 20 minutes.

Affecting the brain: Fluctuating cholesterol levels restrict blood flow to the brain, causing memory loss 

Although the research population was European, the results may be applicable to Americans as their lifestyle patterns predispose them to the same set of clinical outcomes, Smit said. 

But the results cannot be extrapolated directly to the general U.S. population because the study participants were older adults at high risk for vascular disease.

‘These results add an important puzzle piece to the emerging evidence that vascular risk factors are closely related to brain health,’ Smit said. 

‘Our study is just the first exciting step. Further studies are needed to examine whether these findings could truly influence clinical practice.’