HMN 2025: What is the in-silico meta-analysis of pores and skin discoloration therapy

In latest years, the appliance of picosecond laser (PSL) therapy for pores and skin discoloration brought on by nevus of Ota has been advancing within the fields of dermatology, cosmetic surgery, and beauty surgical procedure. However, setting applicable irradiation circumstances is important to realize effectiveness.

This poses a problem as earlier meta-analyses on laser therapy analysis didn’t account for correct laser irradiation ranges. Further, such analyses included outcomes from circumstances with over- and under-irradiation, prompting the necessity for a extra correct analysis.

A analysis group led by Postdoctoral Fellow Yu Shimojo, Specially Appointed Professor Toshiyuki Ozawa, and Professor Daisuke Tsuruta from the Graduate School of Medicine developed the EICF (Excessive Setting Index of Clinical Fluence) indicator utilizing an in-silico mathematical model to find out the suitable laser irradiation circumstances.

The findings had been published in JAAD Reviews.

Based on this index, the irradiation parameters utilized in scientific practice had been evaluated. The group then performed a meta-analysis on therapy research that had been in step with theoretical irradiation circumstances.

In the case of nevus of Ota, a comparability of PSL and nanosecond laser (NSL) therapies revealed that PSL therapy demonstrated increased efficacy and equal security below correct circumstances.

“This achievement supplies scientific proof that solutions questions comparable to ‘Why was it efficient?’ and ‘Why did unintended effects happen?’ in PSL therapy,” mentioned Dr. Shimojo. “Although additional verification is required, we hope EICF can be utilized to make sure safer and more practical laser irradiation circumstances.”