
Breaking the hyperlink between prescription drug record costs and compensation to middlemen like pharmacy profit managers (PBMs) may minimize a good portion of the U.S.’s annual drug tab, finds a brand new evaluation from the USC Schaeffer Center for Health Policy & Economics.
The work is published within the journal Health Affairs Scholar.
PBMs, who negotiate drug advantages on behalf of insurers and employers, are usually paid primarily based on a share of a drug’s record worth earlier than rebates and different reductions are utilized. Federal and state policymakers have proposed delinking PBM compensation from record costs in response to proof that PBMs typically steer sufferers towards higher-priced medication—even when cheaper alternate options can be found—to spice up their very own earnings.
Shifting as a substitute to a clear, fastened cost model for PBMs and different intermediaries within the prescription drug provide chain would cut back annual internet drug spending by $95.4 billion (or almost 15%) with out undermining pharmaceutical innovation, in response to analysis from Schaeffer Center Director of Health Policy Geoffrey Joyce.
Fair compensation
The U.S. spent $650 billion on pharmaceuticals in 2023 after factoring in reductions, with about one-third ($215 billion) flowing to PBMs, wholesalers and pharmacies—although the precise division of those prices is unclear. However, utilizing simplified estimates, Joyce finds spending on these intermediaries would have dropped to $119.6 billion below truthful and clear compensation models.

Here’s how these prices break down:
- PBMs: A set administrative price of $4 per declare would lead to complete prices of $27.6 billion in 2023. Payments to PBMs could possibly be moderately adjusted for hitting value and high quality targets.
- Wholesalers: Entities that buy medication from producers in bulk add a few 3% markup on common to the record worth earlier than promoting to pharmacies, hospitals and long-term care services. Applying that markup to internet costs as a substitute would yield $19.5 billion in complete revenues, lower than the $27.5 billion these companies reported in 2023.
- Pharmacies: A $10.50 per prescription dishing out price would have generated gross venues of $72.5 billion. That charge is usually utilized by state Medicaid packages and aligns with the pricing model utilized by Mark Cuban’s Cost Plus Drug Company.
Reform implications
A proposal to delink PBM compensation from record costs was included in earlier drafts of sweeping home coverage laws earlier than it was dropped from the ultimate model that was just lately enacted. However, policymakers have expressed continued curiosity in reforming PBM practices amid rising proof that these companies use their appreciable market energy to artificially inflate drug costs and prohibit entry to important drugs.
Joyce warns that some generally proposed reforms, similar to these aimed toward curbing consolidation and rising PBM transparency, are too modest to meaningfully change PBM habits given how rapidly the business has shifted techniques within the face of heightened scrutiny.
“Delinking compensation from record costs is the clearest and best method to deal with the warped incentives within the prescription drug provide chain that drive up prices for sufferers with out adversely affecting producers’ incentive to innovate,” says Joyce, who can be chair of the Department of Pharmaceutical and Health Economics on the USC Mann School of Pharmacy and Pharmaceutical Sciences.
More info:
Geoffrey Joyce, The value of misaligned incentives within the pharmaceutical provide chain, Health Affairs Scholar (2025). DOI: 10.1093/haschl/qxaf126
Citation:
Delinking pharmacy profit supervisor compensation from drug record costs may unleash main financial savings ( 24)
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