HMN 2025: How Arginine dentifrices significantly reduce childhood caries

A study in JDR Clinical & Translational Research demonstrates that arginine dentifrices reduce dental caries in children with active caries as effectively as or more effectively than a sodium fluoride dentifrice, depending on the arginine concentration.

Dental caries remain a significant oral health burden globally. Scientific evidence has demonstrated the dose-dependent, anticaries action of fluoride; however, more effective, comprehensive, and alternative prevention strategies should be investigated.

The study, “Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial” by Wei Lin of Sichuan University and colleagues carried out a two-year, phase III, double-blind, three-arm, parallel-group, randomized controlled trial from April 15, 2019 through March 12, 2022 across three centers in China.

Six thousand children aged 10–14 with two or more active caries lesions were assigned one of three study dentifrices: 8.0% arginine, 1.5% arginine, and 0.32% NaF as a positive control. The primary efficacy outcomes were incremental DMFS (decayed, missing, and filled surfaces) and DMFT (decayed, missing, and filled teeth) caries index scores after two years of product use.

After two years, the 8.0% arginine-containing dentifrice demonstrated a statistically significant 26.0% reduction in DMFS and 25.3% in DMFT scores vs. the 0.32% NaF control. No statistical difference was measured between the 1.5% arginine-containing dentifrice and the 0.32% NaF control in DMFS and DMFT.

This clinical study confirms that depending on the concentration, arginine dentifrices are as effective or more effective than a sodium fluoride dentifrice in providing anti-caries protection in children with active caries.

Provided by
International Association for Dental, Oral, and Craniofacial Research