Cancer kills more than 500,000 Americans each year. But today, UC San Francisco researchers are revolutionizing what we thought we knew about how cancer spreads, opening new paths to cures. The paper is published in the journal Nature Cell Biology.
For decades, cancer scientists focused mainly on the genetic mutations that put us at higher risk or fuel the disease by allowing cells to multiply unchecked or trick our natural defenses, for instance. But UCSF Urology Professor Davide Ruggero, Ph.D., helped discover how to block a key protein, MYC, that drives the growth of 70% of all cancers. The breakthrough paves the way for new types of therapies, including at least four experimental drugs developed at UCSF to potentially treat brain cancer (glioblastoma), as well as breast, colorectal, and prostate cancers.
By pairing one of these drugs, which blocks the metabolism of fat, with a high-fat keto diet, Ruggero found that in laboratory studies he could “starve” pancreatic cancer, cutting off the cancer’s energy source, for example.
“Our findings open a point of vulnerability that we can treat with a medicine that we already know is safe in humans,” Ruggero says. “We now have firm evidence of one way in which diet might be used alongside pre-existing cancer therapies to precisely eliminate a cancer.”
More information:
Chenguang Sun et al, Selective translational control by PABPC1 phase separation regulates blast crisis and therapy resistance in chronic myeloid leukaemia, Nature Cell Biology (2025). DOI: 10.1038/s41556-024-01607-4
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