Do you know: MRNA therapies revolutionize a polymer delivery system
Professor Jong Kim from the Department of Chemistry by Postech, in conjunction with Korean Disease Control and Prevention Agency (KDCA) developed a biodegradable delivery system based on a polymer carrying MRNA effectively. The study recently published in Bio -materialsInternational main magazine in the field of biopsy.
Since the Covid-19 pandemic has grown, the global interest in MRNA vaccines. Existing delivery methods include lipid nanoparticles (LNPs) widely due to high -efficiency. However, LNP has a critical disadvantage: when they are injected, they can accumulate in the liver, which may create toxicity or stimulate an excessive immune response, which may lead to anaphylaxis.
To address this issue, the Portech research team explored the polymer in biodegradable Poly ?-amino ester (PBAE) as an alternative. PBAE has already been used to deliver Sirna, DNA, and MRNA and is safely degraded in the body. In this study, the team synthesized 55 types of PBAE polymers and used them to design novel polymers nanoparticles (PNP) for mRNA delivery.
Experimental results showed that the newly developed polymer showed a higher mRNA delivery efficiency compared to normal -LNPs. In addition, MRNA expression lasted up to four weeks-far beyond the normal five-day production period of LNPs. In particular, the polymer only ensured the interpretation of mRNA, with no observable indication in the liver, which eliminated toxicity concerns.
In addition, in immune response experiments, the polymer effectively encouraged T-cell activity and demonstrated comparable performance with LNPs for generating neutralized antibodies against the Covid-19 virus. These results show the potential of polymers based delivery as a safer and more efficient alternative to next generation mRNA vaccines and gene therapies.
Professor Jong Kim won, “Delivery systems have shown an existing LNP, which limits their use for therapeutic applications. Therapeutic mRNA delivery.” He placed further emphasis on it, “The research is This significant as it introduces new polymer content that could be an alternative to LNPs, whose patents are mainly controlled by entities abroad. “
This study was carried out as part of the newly established technology vaccination platform development project, which was implemented by the KDCA National Health Institute and funded the Korean National Research Foundation under the Ministry of Science and ICT.
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