HMN 2025: How Osteoporosis remedy may benefit individuals older than 80

People who’re older than 80 ought to be thought of for osteoporosis remedy after a fracture to keep away from additional threat, in keeping with a review being introduced Saturday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.

“The burden of osteoporosis is rising as the worldwide inhabitants ages quickly,” mentioned Gianina Flocco, M.D., a resident on the Cleveland Clinic in Cleveland, Ohio. “Our study helps the initiation of osteoporosis remedy after a fracture in individuals older than 80 years, because it has been proven to lower each hospitalization and mortality.”

Flocco and colleagues used the TriNextX well being analysis database to check 88,676 sufferers aged 80 and older who suffered a fracture resulting from bone deterioration or weak spot attributable to osteoporosis.

The sufferers have been segmented into two teams. The first included 44,338 sufferers who have been handled with bisphosphonates, denosumab, raloxifene or teriparatide. The second group had the identical variety of sufferers, however included those that did not obtain any osteoporosis therapies.

Patients have been adopted for five years after the preliminary fracture. The analysis accounted for comorbidities, together with hypertension, diabetes, ischemic coronary heart illness, weight problems, coronary heart failure, stroke, COPD, persistent kidney illness, hyperlipidemia, rheumatoid arthritis, neoplasm and vitamin D deficiency.

The sufferers within the remedy group skilled a decrease threat of hospitalization. This group additionally skilled decrease all-cause mortality.

Flocco mentioned that the burden of osteoporosis is predicted to extend sooner or later. These study outcomes assist their suggestion to deal with older sufferers who’re most susceptible to fractures as they proceed to age.

“The outcomes of our study assist the necessity to improve the individualized initiation of remedy of osteoporosis, even in people who find themselves older than 80,” she mentioned. “Treating individuals to cut back the burden of osteoporosis issues, like fractures resulting in incapacity or dying, would play a major position in enhancing well being span within the rising older inhabitants.”