Do you know: The communication between body muscle and brain affects fertility
New communication line between body muscle and the pituitary gland in women’s fertility, according to new studies, may play an unexpected role.
The University of McGill researchers found that protein produced in the muscles helps to manage a hormone made in the median gland connected to the bottom of the brain.
The results, published in ScienceNew treatment options could lead to infertility, the researchers said.
“So far, these two organs have not spoken to each other or how they did so,” said senior author Daniel Bernard, professor in the Department of Pharmacology and McGill Therapies. “This discovery opens a new chapter in our understanding of the body and its complex links.”
How could muscle build a backup
The study pituitary hormone, called follicle-induced hormone (FSH), promotes the maturing of eggs in the ovaries. Deficiency can lead to infertility.
The muscular protein – myostatin – acts as the body’s natural brake on muscle growth.
Working with mice, the researchers found that a reduction in myostatin levels delayed puberty and reduced fertility. Myostatin re -establishment has contributed to FSH levels, but there is still investigation of whether this can restore fertility.
Drugs are designed to block myostatin, to build muscle, being developed to treat conditions such as muscular dystroph. Drug companies are also testing whether myostatin blocking can help preserve muscles in people using weight loss drugs GLP-1, such as ozempic, which could lead to fat loss and muscles.
However, this study raises concerns about the possible health risks of blocking myostatin.
“We found that experimental drugs created to lower muscle waste conditions decreased FSH levels in female mice. While these drugs may grow muscle effectively, there is a risk of interfering with reproductive hormones and fertility,” said the First author of Ongaro Luise, an associate of research in a research associate in a research associate in a research associate in a research associate in a research associate in a research associate in a research associate in a research associate in a research associate of Daniel Bernard’s laboratory research.
Progress also opens the door to explore whether natural variations in myostatin levels of timing of puberty, lost periods in women athletes and infertility when there is no apparent reason.
Going forward, the researchers intend to test whether their results belong to mice, they say promising.
This study supported Canadian health research institutes.
The content material is offered for information solely