How to shut down multiple myeloma's ability to survive and thrive

How to shut down multiple myeloma's ability to survive and thrive

Multiple myeloma is a type of cancer that affects plasma cells, a type of white blood cell found in the bone marrow. It is a complex disease with various genetic and molecular abnormalities that contribute to its survival and growth. However, researchers have recently identified a promising new therapy target that could potentially shut down multiple myeloma’s ability to survive and thrive.

The Role of BCL-2 Protein

One of the key players in multiple myeloma’s survival is a protein called BCL-2. This protein is responsible for preventing programmed cell death, or apoptosis, in cancer cells. By inhibiting apoptosis, BCL-2 allows cancer cells to evade the body’s natural defense mechanisms and continue to grow uncontrollably.

Targeting BCL-2 with Venetoclax

Venetoclax is a targeted therapy that has shown promising results in shutting down BCL-2 and inducing apoptosis in cancer cells. Originally developed for the treatment of chronic lymphocytic leukemia, venetoclax has now been tested in multiple myeloma patients with encouraging outcomes.

A recent clinical trial involving patients with relapsed or refractory multiple myeloma demonstrated that venetoclax, in combination with other standard therapies, significantly improved overall response rates and progression-free survival compared to standard therapies alone. This suggests that targeting BCL-2 with venetoclax could be an effective strategy to overcome multiple myeloma’s ability to survive and thrive.

Future Implications

The discovery of venetoclax as a potential therapy target for multiple myeloma opens up new possibilities for the treatment of this challenging disease. Further research is needed to fully understand the mechanisms of action and potential side effects of venetoclax in multiple myeloma patients.

Additionally, ongoing clinical trials are investigating the efficacy of venetoclax in combination with other targeted therapies or immunotherapies, aiming to further enhance treatment outcomes and potentially achieve long-term remission in multiple myeloma patients.


The identification of BCL-2 as a therapy target and the development of venetoclax as a potential treatment option represent significant advancements in the fight against multiple myeloma. By shutting down multiple myeloma’s ability to survive and thrive, venetoclax offers hope for improved outcomes and better quality of life for patients with this challenging disease.