Menopausal drug that ‘turns off’ hot flashes in just days could be available by year’s end after being approved in the US as a lifeline for hundreds of thousands of women unable to take hormone replacement therapy
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- The first non-hormonal drug for menopause, called fezolinetant, acts on the brain
- Women reported a reduction in hot flash severity and better sleep quality
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By the end of the year, an anti-menopausal drug could be available that “turns off” hot flashes in just days.
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The ‘game-changing’ drug, called fezolinetant, acts directly on the brain and could be a lifeline for hundreds of thousands of women unable to take hormone replacement therapy (HRT).
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Earlier this month, the US approved fezolinetant, the first non-hormonal menopause drug.
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Its makers describe it as a therapy “based on our understanding of the biology behind hot flashes.”
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The drug works by blocking a brain protein called neurokinin 3, which plays a role in regulating body temperature in menopausal women.
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An anti-menopausal drug that ‘turns off’ hot flashes in just days could be available by the end of the year (file image)
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The ‘groundbreaking’ drug, called fezolinetant, could be a lifeline for hundreds of thousands of women unable to take hormone replacement therapy (HRT) (file image)
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A large study published this year found that taking the pill once a day for 12 weeks reduced the frequency of hot flashes by about 60 percent in women with moderate or severe symptoms, compared with a 45 percent decrease in those taking a placebo. got.
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Women also reported a reduction in hot flash severity and better sleep quality.
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“This is going to be a complete blockbuster drug,” said Professor Waljit Dhillo, an endocrinologist at Imperial College London.
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“It’s like a switch. Within a day or two the hot flashes disappear – it’s amazing how well these drugs work.
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“It will completely change for many women.”
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Fezolinetant, made by the Japanese company Astellas Pharma, is now under review by the European Medicines Agency.
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A decision is expected this year, followed by the UK several months later.
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The drug does not affect estrogen levels – which drop sharply during menopause – so will not address symptoms of fatigue and mood swings the way HRT does.
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But HRT isn’t for everyone, including people with a history of breast or ovarian cancer.
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‘If you can’t take HRT, there aren’t many really effective options,’ says Professor Annice Mukherjee, a consultant endocrinologist at Coventry University. “Women need options.”
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Menopause drug that ‘switches off’ hot flushes could be available by the end of the year
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