{"id":291369,"date":"2023-05-19T19:19:59","date_gmt":"2023-05-19T19:19:59","guid":{"rendered":"https:\/\/publicnewstime.com\/health-news\/targeting-cellular-respiration-as-a-therapeutic-strategy-in-glioblastoma\/"},"modified":"2023-05-19T19:19:59","modified_gmt":"2023-05-19T19:19:59","slug":"targeting-cellular-respiration-as-a-therapeutic-strategy-in-glioblastoma","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/i\/targeting-cellular-respiration-as-a-therapeutic-strategy-in-glioblastoma\/","title":{"rendered":"Targeting cellular respiration as a therapeutic strategy in glioblastoma"},"content":{"rendered":"<p> A new research perspective, titled &#8220;Targeting cellular respiration as a therapeutic strategy in glioblastoma,&#8221; was published in <i>Oncotarget<\/i> on May 4, 2023.n                                                <\/p>\n<p>n<\/p>\n<p>While glycolysis is abundant in malignancies, mitochondrial metabolism is significant as well. Mitochondria harbor the enzymes relevant for energy production<\/a> in the form of ATP.n<\/p>\n<p>n<\/p>\n<p>In this research perspective, researchers Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, and Markus D. Siegelin from Columbia University Medical Center, City University of New York and Ulm University Medical Center discuss their recent finding that FDA-approved HDAC-inhibitors may have a profound impact on energy metabolism<\/a> in solid tumor cells, including glioblastoma (GBM).n<\/p>\n<p>n<\/p>\n<p>&#8220;Because of the impact of HDAC-inhibitors on metabolism we hypothesized that imipridones, which suppress cellular respiration, might synergize with these compounds<\/a> to significantly enhance killing of GBM cells. Indeed, we found that imipridones reversed HDAC-inhibitor induced activation of cellular respiration and in turn the combination treatment facilitated induction of intrinsic apoptosis in a manner that was partially reliant on the anti-apoptotic Bcl-2 family members,&#8221; say the authors.<\/p>\n<p>n<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">n    <meta itemprop=\"name\" content=\"Targeting cellular respiration as a therapeutic strategy in glioblastoma\"\/><br \/>n    <meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=xce3RfZUfvk\"\/><br \/>n    <meta itemprop=\"description\" content=\"Credit: Impact Journals LLC\"\/><br \/>n    <meta itemprop=\"uploadDate\" content=\"2023-05-19T14:05:14-04:00\"\/><br \/>n        <meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/xce3RfZUfvk\"\/><br \/>n    <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/xce3RfZUfvk\/maxresdefault.jpg\"\/><\/p>\n<p>n<\/p>\n<p>n             <iframe loading=\"lazy\" title=\"Targeting Cellular Respiration as a Therapeutic Strategy in Glioblastoma | Oncotarget\" width=\"1220\" height=\"686\" src=\"https:\/\/www.youtube.com\/embed\/xce3RfZUfvk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>n         <\/p><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">Credit: Impact Journals LLC<\/figcaption><\/figure>\n<p>n<\/p>\n<p>n<\/p>\n<p>The oxidation of NADH2 and FADH2 are fundamental since NAD and FAD are the key components of the TCA-cycle that is critical to entertain biosynthesis in cancer cells. The TCA-cycle itself is predominantly fueled through carbons from glucose, glutamine, fatty acids and lactate.n<\/p>\n<p>n<\/p>\n<p>Targeting mitochondrial energy metabolism appears feasible through several drug compounds<\/a> that activate the CLPP protein or interfere with NADH-dehydrogenase, pyruvate-dehydrogenase, enzymes of the TCA-cycle and mitochondrial matrix chaperones. While these compounds have demonstrated anti-cancer effects in vivo, recent research suggests which patients most likely benefit from such treatments.n<\/p>\n<p>n<\/p>\n<p>&#8220;In summary, targeting tumor cell metabolism is relevant and future research needs to identify patient populations that particularly benefit from such treatments. Moreover, while most studies related to metabolism<\/a> still rest predominantly on the tumor cells it is critical to extend such observations to the microenvironment of the tumors, especially with regards to the immune system,&#8221; conclude the researchers.<\/p>\n<p>n<\/p>\n<div class=\"article-main__more p-4\">n<\/p>\n<p><strong>More information:<\/strong><br \/>n                                                    Enyuan Shang et al, Targeting cellular respiration as a therapeutic strategy in glioblastoma, <i>Oncotarget<\/i> (2023).  DOI: 10.18632\/oncotarget.28424<\/a><\/p>\n<p>n<\/p>\n<\/div>\n<p>n<\/p>\n<p>n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tImpact Journals LLC<\/p>\n<p>n<\/p>\n<p>                                        <!-- print only --><\/p>\n<p>n<\/p>\n<div class=\"d-none d-print-block\">n<\/p>\n<p>n                                                 <strong>Citation<\/strong>:<br \/>n                                                 Targeting cellular respiration as a therapeutic strategy in glioblastoma (2023, May 19)<br \/>n                                                 retrieved 19 May 2023<br \/> n<\/p>\n<\/div>\n<p>n<\/p>\n<\/div>\n<p>n<\/p>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><br \/>n<br \/>nn<\/p>\n<p>n<\/p>\n<p>Most Related Links :<br \/>nAutomobile News<\/a><br \/>n<br \/>nn<\/p>\n<p>Root link<\/a><\/p>\n<p>n<\/p>\n<p>Public News Time<\/a><\/p>\n<p>n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new research perspective, titled &#8220;Targeting cellular respiration as a therapeutic strategy in glioblastoma,&#8221; was published in Oncotarget on May 4, 2023.n n While glycolysis is abundant in malignancies, mitochondrial metabolism is significant as well. Mitochondria harbor the enzymes relevant for energy production in the form of ATP.n n In this research perspective, researchers Enyuan <a class=\"read-more-link\" href=\"https:\/\/healthmedicinet.com\/i\/targeting-cellular-respiration-as-a-therapeutic-strategy-in-glioblastoma\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-291369","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/291369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=291369"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/291369\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=291369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=291369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=291369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}